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Apoptosis Induced by High Concentrations of nicotinamide in Tobacco Suspension Cells

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Tsinghua Science and Technology 2004年第1期9卷 88-93页

作者：张贵友朱瑞宇戴尧仁 Department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 China

As an inhibitor of poly(ADP-ribose) polymerase (PARP), nicotinamide has a restraining effect on apoptosis at certain low concentrations. In our present study, apoptosis induced by high concentrations of nicotinamide was observed in tobacco suspension cells. When cells were preincubated with 250 mmol/L nicotinamide for 24 h, the hallmarks of apoptosis were detected, including DNA fragments increasing in size by multiples of 180-200 bp, the condensation and peripheral distribution of nuclear chromatin, and a positive reaction to the TUNEL assay. At the same time, the degradation of PARP and the reduction in the potential of the inner membrane of mitochondria appeared in apoptotic cells induced by high concentrations of nicotinamide. This result indicates that apoptosis induced by high concentrations of nicotinamide is associated with caspase-3-like activity and with the opening of mitochondrial permeability pores. These results partially support the hypothesis that high concentrations of PARP inhibitor could force cells to enter an apoptotic pathway by delay of DNA repair in replicating cells.

关键词： apoptosis nicotinamide tobacco suspension cell poly (ADP-ribose) polymerase

nicotinamide Inhibition Properties for Copper Corrosion in 3.5% NaCl Solution: Experimental and Theorical Investigations

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Journal of Materials Science and Chemical Engineering 2018年第3期6卷 100-121页

作者： Coulibaly Nagnonta Hippolyte Brou Yapi Serge Akpa Sagne Juan Creus Trokourey Albert Laboratoire de Chimie Physique (LCP) Université Félix Houphouet-Boigny d’Abidjan Abidjan Cote d’Ivoire Laboratoire de Chimie Organique et de Substances Naturelles (LCOSN) Université Félix Houphouet-Boigny d’Abidjan Abidjan Cote d’Ivoire Laboratoire des Sciences de l’Ingénieur pour l’Environnement (LaSIE) Université de La Rochelle La Rochelle France

This work reports the inhibition properties of nicotinamide (NAM) for copper protection during its applications in seawater systems such as water pipelines, shipbuilding, seawater desalination and heat exchange systems. The efficiency of NAM as a copper corrosion inhibitor in simulated seawater (3.5% NaCl solution) was investigated by Tafel extrapolation and linear polarization methods in the temperature range from 20℃ to 50℃. The corrosion parameters and the adsorption isotherms were determined using potentiodynamic polarization techniques. It was found that the inhibition efficiency (η) and the coverage rate (θ) increase up 80% at 25℃ for nicotinamide concentration of 10 mM but decrease as the temperature of the solution increases. Moreover, the obtained thermodynamic parameters using Langmuir model suggested a physical adsorption type. A correlation was found between the corrosion inhibition efficiency and the global theoretical parameters obtained by the functional density method B3LYP/ 6-31 + G (d, p). Local parameters such as condensed Fukui functions [f(r)] and condensed local softness [s(r)] indices have also been determined to obtain a chemical insight into atoms that have a significant tendency toward donation or acceptance of whole or fraction of electrons.

关键词： nicotinamide Copper Corrosion Inhibition Electrochemical Techniques

nicotinamide reverses liver fibrosis in a thioacetamide induced mouse model

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Nicotinamide reverses liver fibrosis in a thioacetamide indu...

Physiological Role of Humic Acid and nicotinamide on Improving Plant Growth, Yield, and Mineral Nutrient of Wheat (<i>Triticum durum</i>) Grown under Newly Reclaimed Sandy Soil

2018年中国质谱学术大会（CMSC2018）

作者： Zhaoyun Zong Jing Liu Jie Jin Haiteng Deng MOE Key Laboratory of Bioinformatics School of Life SciencesTsinghua University

Liver fibrosis is a common liver disease mainly due to chronic viral hepatitis, high fat diet and alcoholism. Previous studies have shown that reactive oxygen species(ROS) are produced during this process. nicotinamide adenine dinucleotide(NAD+) as a vital hydrogen carrier for redox enzymes plays important roles in redox reactions of cells. As a major NAD+ precursor, nicotinamide(NAM) can synthesize NAD+ by salvage pathway. This study investigates the therapy roles of NAM in liver fibrosis by using a thioactamide induced mouse model. The results show that NAM reverses liver fibrosis in a mouse model induced by thioacetamide. Furthermore, metabolomics and proteomics analysis reveals that NAM suppresses the activation of hepatic stellate cells via maintaining vitamin A content and inhibiting the expression of SMAD2 in hepatic stellate cells. In conclusion, these findings provide new insights into a potential treatment against liver fibrosis.

关键词： NAD+ nicotinamide liver fibrosis

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Agricultural Sciences 2014年第8期5卷 687-700页

作者： Hala Safwat Mohamed El-Bassiouny Bakry Ahmed Bakry Amany Abd El-Monem Attia Maha Mohamed Abd Allah Agronomy Department Agriculture and Biology Division National Research Center Cairo Egypt Botany Department Agriculture and Biology Division National Research Center Cairo Egypt

Humic acid is not a fertilizer as it does not directly provide nutrients to plants, but is a compliment to fertilizer. nicotinamide (Vitamin pp) is a stress-associated compound that can induce and regulate secondary metabolic accumulation and/or the manifestation of defense metabolism in plants. A field experiment was conducted at the experimental station of National Research center at El-Nubaria region, Egypt, to study the role of foliar application of humic acid (as soil conditioner 13 cm/l) and/or priming grains in nicotinamide (vitamin pp 5 mg/l) in saving irrigation water, decreasing fertilizer dose of NPK and at the same time increasing durum wheat (Triticum durum) cultivars’ (Beni Sweif-1 and Beni Sweif-3) productivity grown under newly reclaimed sandy soil exposed to drought for three weeks continuously. The results showed that plant treated with humic acid or nicotinamide increased significantly all morphological criteria (plant height, leaves number, fresh and dry weights of shoots), metabolism (photosynthetic pigment, total soluble sugar, total carbohydrates, total amino acids and proline), mineral contents (N, P, K, Ca and Mg) and yield (grain, straw and biology) of both cultivars amended with either recommended or half recommended doses of NPK. Foliar application of humic acid to plant priming in Vitamin pp induced significant increases in all studied parameters (morphology, chemical and yield) of plants amended with recommended or half recommended doses of NPK as compared with control plants. The maximum yields of grain, straw and biology of both cultivars were obtained in response to triple treatment (humic acid + nicotinamide + recommended dose of NPK) or (humic acid + nicotinamide + half recommended dose of NPK) respectively.

关键词： Humic Acid Metabolism Mineral Ions nicotinamide Wheat

Study of Tripterygium Associated with nicotinamide in Treating Late-onset Autoimmune Diabetes Mellitus in Adults

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Chinese Journal of Integrated Traditional and Western Medicine 2004年第3期10卷 193-196页

作者：刘江华段世芳刘志文刘宗汉曹仁贤文芳文格波 The First Affiliated Hospital to Nanhua University Huna Hengyang (421001) China The Second Hospital of Xiangya Zhongnan University Biochemistry and Bio-technology Experimental Center Nanhua University

Objective: To explore the effect of Tripterygium polyglycoside (TP) associated with nicotinamide on the islet cell function, immune parameters and lipoperoxide (LPO) in adult patients with late-onset autoimmune diabetes mellitus (LADA). Methods: Thirty-six cases of LADA were randomly divided into three groups: TP group (n=12), treated with TP plus orally taken metformin; combined treatment group (n= 12), treated with TP combined with nicotinamide and metformin, and control group (n=12) treated with metformin alone. They were followed-up for 18 months. Results: (1) Compared with the control group after 9 months of treatment, postprandial plasma glucose and LPO in combined treatment group were decreased (P nicotinamide played a role in immunity regulation, decreasing the titer of islet cell antibody and slL-2R, which also reduced the production of LPO and had a tendency to improve islet cell function in early LADA patients.

关键词： late-onset autoimmune diabetes mellitus in adults Tripterygium nicotinamide

Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

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Neural Regeneration Research 2024年第8期19卷 1728-1733页

作者： Sanika M.Joshi Theresa Currier Thomas Nafisa M.Jadavji College of Osteopathic Medicine Midwestern UniversityGlendaleCAUSA Department of Biomedical Sciences Midwestern UniversityGlendaleCAUSA Department of Child Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary Medicine Midwestern UniversityGlendaleCAUSA Department of Neuroscience Carleton UniversityOttawaCanada

Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals ***-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic ***,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more *** aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain ***,Web of Science,and Google Scholar databases were searched for studies that examined the impact of B-vitamin supplementation on traumatic brain injury *** search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplementation of B-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to *** r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain *** details of supplementation post-traumatic brain injury need to be further ***,we conclude that B-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model *** investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.

关键词： folic acid nicotinamide one-carbon metabolism riboflavin traumatic brain injury vitamin B12 vitamin B2 vitamin B3

Syntheses, Crystal Structures and Antitumor Activities of Two nicotinamides

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Chinese Journal of Structural Chemistry 2013年第5期32卷 631-636页

作者：王智樊一桥罗丹梦石磊 Department of Medicinal Chemistry China Pharmaceutical University

Two nicotinamides have been synthesized by coupling aromatic amines with equimolar quantities of substituted nicotinic acids. Their structures have been determined by X-ray single-crystal diffraction. Compound 1, 6-chloro-N-（4-fluorophenyl）nicotinamide, crystallizes in the triclinic space group Pī with a = 4.2188（8） , b = 5.0687（10）, c = 25.956（5）, α = 86.38（3）, β = 87.75（3）, γ = 83.20（3）°, V = 549.75（19） 3 and Z = 2. Compound 2, N-（quinolin-3-yl）nico- tinamide, crystallizes in the monoclinic space group P21 with a = 8.5100（17）, b = 6.4230（13）, c = 11.620（2） , β = 110.39（3）°, V = 595.3（2） 3 and Z = 2. The cytotoxic activities of the two nicotinamides against five human tumor cell lines were tested in vitro. The results indicated that they showed a wide range of antitumor activities.

关键词： synthesis crystal structure antitumor nicotinamide

Plasma metabolic profiling reveals that chromium yeast alleviates the negative effects of heat stress in mid-lactation dairy cows

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Animal Nutrition 2023年第2期13卷 401-410页

作者： Yeqianli Wo Fengtao Ma Qiang Shan Duo Gao Yuhang Jin Peng Sun State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China

Chromium yeast(CY)supplementation has the potential to alleviate the negative effects of heat stress in dairy cows,but the mechanism remains *** aimed to identify the metabolic mechanisms whereby CY supplementation alleviates the negative effects of heat stress in mid-lactation dairy *** Holstein dairy cows with similar milk yield(24.6±1.5 kg/d),parity(2 or 3)and days in milk(125±8 d)were fed the same basal diet containing 0.09 mg of Cr/kg *** were allocated randomly to 2 groups:a control group(CON,without CY supplementation)and a CY group(CY,administered 0.36 mg Cr/kg DM).The experiment was performed over 8 weeks during a hot summer,in which the mean temperature-humidity index was 79.0±3.13(>72),indicating that the dairy cows were exposed to heat *** yeast supplementation reduced rectal temperature(P=0.032),and increased the lactation performance by increasing the yield of milk(+2.6 kg/d),protein,lactose and total solid,and protein and lactose percentages in the milk of the heat-stressed dairy cows(P1.0,Pnicotinamide ***,plasma concentration of nicotinamide was higher after CY supplementation,which might also contribute to the reduction of rectal temperature,the regulation of glucose homeostasis,and an improvement in the lactation performance of heat-stressed dairy *** conclusion,CY supplementation reduces re

关键词： Chromium yeast Heat stress Metabolomics nicotinamide Dairy cow

A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity

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Acta Pharmaceutica Sinica B 2018年第2期8卷 188-199页

作者： Eneida Turiján-Espinoza Rául Alejandro Salazar-González Edith Elena Uresti-Rivera Gloria Estela Hernández-Hernández Montserrat Ortega-Juárez Rosa Milán Diana Portales-Pérez Laboratory of Immunology and Cellular and Molecular Biology Faculty of Chemical Science UASLP Laboratory of Biopharmacy and Pharmacokinetics Faculty of Chemical Science UASLP

Arylamine N-acetyltransferase(NAT; E.C. 2.***.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPLC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins.

关键词： Arylamine N-acetyltransferase NAT Sirtuins Peripheral blood mononuclear cells nicotinamide Resveratrol