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Recent advances in development of devices and probes for sensing and imaging in the brain

Science China Chemistry 2021年第6期64卷 915-931页

作者： Zhichao Liu Yang Tian Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China

As the most important part of the central nervous system,the brain is extremely complex in structure and *** vivo analysis of chemical signals is an essential way to investigate brain activity and *** functional magnetic resonance imaging(fMRI)or electrophysiology can be used to record brain activity,they are usually limited by low spatiotemporal fidelity or the difficulty of distinguishing the contributions of various *** addition,the development of in vivo biosensors with high selectivity and accuracy is essential to understand the roles that neurochemicals play in the *** this review,we focus on the development of instruments and devices for recording chemical signals in the live ***,the strategies for development of electrochemical and fluorescent probes with high selectivity,high accuracy and good stability are also *** particular,this review highlighted the contributions of our research group to this *** development of techniques and probes enable us to understand the brain structure and function,and the mechanism of brain diseases,providing the solution for preventing and treating brain diseases.

关键词： brain chemistry neurochemicals instruments and devices bioimaging biosensing

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Implantable optical fiber microelectrode with anti-biofouling ability for in vivo photoelectrochemical analysis

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Chinese Chemical Letters 2023年第3期34卷 259-263页

作者： Lixia Tao Yao Kong Yunhui Xiang Yu Cao Xiaoxue Ye Zhihong Liu College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical Engineering Wuhan 430072China

In-situ monitoring of neurochemicals is of vital importance for the understanding of brain ***-based photoelectrochemical(PEC) sensing has emerged as a promising tool for in vivo analysis since it inherits the merits of both optical and electrochemical methods. However, the in-situ excitation of photoactive materials on the photoelectrode in living body is still a challenge because of limited tissue penetration depth of light. To circumvent this problem, we herein developed an implantable optical fiber(OF)-based microelectrode for in vivo PEC analysis. The working electrode was constructed by coating Au film as conducting layer and CdS@ZnO as photoactive material on a micron-sized OF,which was free of the limitation of light penetration in biological tissues. Further decoration of an antibiofouling layer on the surface made the sensor robust in biosamples. It was successfully applied for monitoring Cu^(2+) level in three different brain regions in the rat model of cerebral ischemia/reperfusion.

关键词： Optical fiber Implantable microelectrode Photoelectrochemical sensing In vivo analysis neurochemicals

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Hewei Jiangni granule alleviates visceral hypersensitivity in a rat model of non-erosive reflux disease via transient receptor potential channel signaling

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Journal of Traditional Chinese Medical Sciences 2020年第2期7卷 162-170页

作者： Jiali Liu Fushun Kou Xiang Tan Yi Dai Chune Xie Xiaohong Li Lei Shi Tangyou Mao Xiaojun Shi Junxiang Li Graduate School of Beijing University of Chinese Medicine Beijing100029China Department of Gastroenterology Dongfang HospitalBeijing University of Chinese MedicineBeijing100078China Department of Pharmacotherapy and Oriental Medicine School of PharmacyHyogo University of Health SciencesHyogo650-8530Japan School of Life Sciences Beijing University of Chinese MedicineBeijing102488China

Objective:To uncover the underlying mechanism of Hewei Jiangni granule(HWJNG)on non-erosive reflux disease(NERD)treatment by examining histological changes,gastrointestinal neurochemicals release and visceral hypersensitivity-related receptor expression in NERD model ***:A NERD rat model was established via a combination of basal sensitization and acid *** treatments at different doses were then *** changes to tissues,mast cell(MC)activation,serum levels of esophageal visceral hypersensitivity-related neurochemicals,and transient receptor potential(TRP)receptor mRNA and protein levels were ***:Compared with the control group,the expression of tryptase in MCs,the changes of intercellular space,and the serum levels of substance P(SP),calcitonin gene-related peptides(CGRP)and proteinaseactivated receptor 2(PAR2)increased in the model group(all P<.05).The expression of TRP vanilloid 1(Trpv1)mRNA decreased in esophagus and dorsal root ganglia(DRG)of the model group(P=.030&P=.013),and the expression of TRP melastatin channel subfamily member 8(Trpm8)mRNA decreased in the esophagus of model group(P<.01).The level of esophageal TRPV1 protein increased in the model group(P<.01)and the level of TRPM8 protein decreased in esophagus and DRG of the model group(both P<.05).Compared with the model group,the serum levels of SP,CGRP,and PAR2 in the mediumdose HWJNG group showed significant decreases(all P<.05).The expression of Trpv1 mRNA in esophagus and DRG of the HWJNG groups and the Omeprazole group remarkably decreased(all P<.05),as was the expression of Trpm8 mRNA in esophagus of the HWJNG groups(all P<.05).Conclusion:HWJNG alleviated visceral hypersensitivity in NERD model rats by regulating TRP-mediated *** results indicate that HWJNG has potential as a therapeutic agent for NERD.

关键词： Hewei jiangni granule Non-erosive reflux disease Esophageal visceral hypersensitivity Transient receptor neurochemicals

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