Recent advances in development of devices and probes for sensing and imaging in the brain

作     者：Zhichao Liu Yang Tian Zhichao Liu;Yang Tian

作者机构：Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2021年第64卷第6期

页      面：915-931页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 080202[工学-机械电子工程] 08[工学] 0802[工学-机械工程] 0836[工学-生物工程] 

基　　金：This work was supported by the National Natural Science Foundation of China(21635003,21827814,21811540027,22004037) the Innovation Program of Shanghai Municipal Education Commission(201701070005E00020) the China Postdoctoral Science Foundation(2019TQ0095,2020M681225) 

主　　题：brain chemistry neurochemicals instruments and devices bioimaging biosensing 

摘      要：As the most important part of the central nervous system,the brain is extremely complex in structure and *** vivo analysis of chemical signals is an essential way to investigate brain activity and *** functional magnetic resonance imaging(fMRI)or electrophysiology can be used to record brain activity,they are usually limited by low spatiotemporal fidelity or the difficulty of distinguishing the contributions of various *** addition,the development of in vivo biosensors with high selectivity and accuracy is essential to understand the roles that neurochemicals play in the *** this review,we focus on the development of instruments and devices for recording chemical signals in the live ***,the strategies for development of electrochemical and fluorescent probes with high selectivity,high accuracy and good stability are also *** particular,this review highlighted the contributions of our research group to this *** development of techniques and probes enable us to understand the brain structure and function,and the mechanism of brain diseases,providing the solution for preventing and treating brain diseases.