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Effectiveness and safety of seven oral Chinese patent medicines as adjuvant therapy for cancer-related anemia: A systematic review and network meta-analysis of randomized controlled trials

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Journal of Traditional Chinese Medical Sciences 2023年第2期10卷 150-160页

作者： Jing Xu Kang Wu Xiao Li Chiah Shean Teo Guangda Li Yiming Pan Li Hou First School of Clinical Medicine Beijing University of Chinese MedicineBeijing100029China Department of Oncology and Hematology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Institut Kanser Negara Ministry of Health MalaysiaPutrajaya62250Malaysia

Objective:To evaluate the effectiveness and safety of seven oral Chinese patent medicines(CPMs)as adjuvant therapy for cancer-related anemia(CRA)by network meta-analysis(NMA).Methods:A literature search to obtain randomized controlled trials(RCTs)of seven oral CPMs in the adjuvant treatment of CRA was conducted in multiple databases from the inception to April *** RevMan5.3 and R 4.1.1 software were used for ***:We ultimately included 29 RCTs with 2140 *** meta-analysis showed that Fufang E'jiao syrup(FFEJS),Shengxuebao mixture(SXBM),Shengxuening tablets(SXNT),Jianpi Shengxue granules(JPSXG),and Yixuesheng capsule(YXSC)combined with basic Western treatment(BWT)could improve the hemoglobin(HGB)*** combined with BWT could improve the red blood cell(RBC).FFEJS combined with BWT improved the Karnofsky performance status(KPS).NMA showed that FFEJS,JPSXG,SXBM,and SXNT plus BWT improved HGB better than Shengxue tablets(SXT)plus BWT,with top three ranking results being JPSXG plus BWT>SXNT plus BWT>FFEJS plus *** plus BWT,JPSXG plus BWT,SXBM plus BWT,SXNT plus BWT,and SXT plus BWT improved RBC better than BWT,with top three ranking results being SXNT plus BWT>JPSXG plus BWT>FFEJS plus *** terms of the KPS score,compared with SXT plus BWT,FFEJS,JPSXG,SXBM,SXNT,and Yizhong Shengxue capsule(YZSXC)plus BWT had higher KPS,with top three ranking results being SXBM plus BWT>JPSXG plus BWT>FFEJS plus ***:Our NMA demonstrated that seven oral CPMs used as adjuvant treatment of CRA had a definite clinical *** not only increases the levels of HGB and RBC to enhance the clinical effect but also improves patients'quality of *** accurate conclusions need to be verified by more high-quality RCTs.

关键词： Cancer-related anemia Chinese patent medicine network meta-analysis Effectiveness Safety

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Efficacy and complications of transarterial chemoembolization alone or in combination with different protocols for hepatocellular carcinoma: A Bayesian network meta-analysis of randomized controlled trials

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iLIVER 2023年第2期2卷 130-141页

作者： Jingxin Yan Manjun Deng Ting Li Changhao Dong Minglan Wang Shunyu Kong Yingxing Guo Haining Fan Department of Interventional Therapy Affiliated Hospital of Qinghai UniversityXiningChina Department of Postgraduate Qinghai UniversityXiningChina Department of Hepatopancreatobiliary Surgery Affiliated Hospital of Qinghai UniversityXiningChina Qinghai Province Key Laboratory of Hydatid Disease Research XiningChina Department of Postgraduate Chengdu Medical CollegeChengduChina School of Medicine South China University of TechnologyGuangzhouChina Department of Postgraduate Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Background and aims:Transarterial chemoembolization(TACE)is the standard treatment for most intermediate-toadvanced stage hepatocellular *** the ongoing development of interventional therapies,TACE in combination with different protocols is being explored.A network meta-analysis to collect recent evidence in this field is ***:We searched PubMed,Web of Science,Cochrane Central Register of Controlled Trials,Embase,Chinese National Knowledge Infrastructure database,Cochrane Library,and Wanfang database from their inception to May 2022 for randomized controlled trials(RCTs)that reported TACE in combination with different protocols for hepatocellular ***:In total,67 RCTs assessing eight combination treatments were *** quality of primary outcomes was from moderate to *** Bayesian network meta-analysis confirmed that TACE combined with iodine-125 seed implantation had the highest probability of 1-year survival rate and TACE combined with sorafenib had the highest probability of 2-year survival *** alone had the highest probability of incidence of fever,TACE combined with sorafenib had the highest probability of incidence of pain and TACE combined with percutaneous ethanol injection had the highest probability of incidence of nausea and ***:This Bayesian network meta-analysis found that TACE combined with iodine-125 seed and TACE combined with sorafenib may benefit patients in terms of 1-year survival and 2-year survival,*** confirm this conclusion,high-quality and well-designed RCTs with a larger sample size are needed.

关键词： Bayesian method network meta-analysis TACE HCC

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Comparative efficacy of traditional Chinese herbal injection for chronic renal failure:A systematic review and network meta-analysis of randomized controlled trials

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 83-99页

作者： Dongni Shi Feng Liang Xihong Wang Nana Wang Lin Zhang Wanting Cui Jiashuai Deng Chung Tai Lau Luofan Zhang Xuan Zhang School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China Department of Nephropathy First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Ministry of Education Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China

Objective: To conduct a systematic review and network meta-analysis(NMA) for the comparison of the efficacy and safety of Chinese herbal injection(CHI) combined with Western medicine(WM) and WM monotherapy for chronic renal failure(CRF).Methods: Eight databases were searched from inception to August 30, 2022. Randomized controlled trials(RCTs) regarding the comparison of CHI-WM combination therapy and WM monotherapy were included. Literature search, risk-of-bias assessment, and data extraction were conducted by 2 reviewers independently. NMA was performed by Stata 14.0, R 4.0.4 software, and the latest risk of bias assessment tool 2(RoB 2).Results: A total of 53 RCTs were finally included, involving 4445 participants and 16 CHIs. RoB 2 showed that 2 of these studies had a high risk of bias. Tianqi injection(TQ) + WM was the most effective in reducing serum creatinine(Scr) level. Xingding injection(XD) + WM was the most effective in reducing blood urea nitrogen(BUN) and cystatin C(Cys C) levels. Guhong injection(GH) + WM had the highest endogenous creatinine clearance rate(Ccr). Shuxuetong injection(SXT) + WM was the most effective in improving the clinical effective rate. Danhong injection(DH) + WM resulted in the lowest 24-h urinary protein quantity(24 h-UPQ), while Danshen injection(DS) + WM led to the lowest blood uric acid(UA)level. Shenfu injection(SF) + WM was the most effective in increasing hemoglobin(Hb) ***: CHIs-WM combination therapy is more effective than WM monotherapy in treating *** all of the indicators, SK + WM may be the optimal treatment option for improving renal function in patients with CRF.

关键词： Chronic renal failure Chinese herbal injections Combination therapy Systematic review network meta-analysis

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Effects of Different Extract of Pseudostellaria Heterophylla on Immunological Function in Mice based on meta-analysis and network meta-analysis

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Agricultural Science & Technology 2021年第2期22卷 51-58页

作者： ZHANG Yan-da PAN Hui-qing MA Yu-fang SHI Shao-hua ZHAO Qi Municipal Enterprise Technical Center of Fujian Beidi Pharmaceutical Co. Ltd.Ningde 355300PRC Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health Fujian Agriculture and Forestry UniversityFuzhou 350002PRC Institute of Animal Husbandry and Veterinary Medicine Fujian Academy of Agricultural SciencesFuzhou 350013PRC

To evaluate the effects of different extract of Pseudostellaria heterophylla on immunological function in mice based on meta-analysis and network meta-analysis,the article retrieved domestic and foreign databases according to the"PICO"retrieval strategy,and used Stata and ADDIS software for meta analysis.A total of 6 reports,10 randomised controlled trials(RCTs)were eventually *** analysis results showed that:compared with the control group,the experimental group of polysaccharide,saponin and crude extract were better than that of the control(Pmeta-analysis results showed that the saponin had the best effect on the increase of phagocytic index and the differences were statistically significant[MD=1.50,95%CI(0.71,2.28),Ppolysaccharide>saponin;the probability for the components of Pseudostellaria heterophylla increasing thymus index of mice was in the order of saponin>polysaccharide>crude *** on the available evidence,the extract of Pseudostellaria heterophylla could improve the immunity of mice,and the clinical effect of polysaccharide and saponin was the best,which provided a more valuable scientific reference for evidencing that the polysaccharide and saponin of Pseudostellaria heterophylla was the effective c

关键词： Pseudostellaria heterophylla Extraction Mice Immunological function network meta-analysis

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Comparison of Efficacy and Safety of Artemisinin-Based Combination Therapies for Treating Uncomplicated Falciparum Malaria in Sub-Saharan African Countries: An Update on the Changes in Efficacy Using network meta-analysis

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Advances in Infectious Diseases 2022年第3期12卷 405-421页

作者： Solange Whegang Youdom Roméo Simeu Tchouenkou Eugène-Patrice Ndong-Nguéma Leonardo K. Basco Department of Public Health Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon National Advanced School of Engineering University of Yaounde I Yaounde Cameroon Aix Marseille University IRD AP-HM SSA VITROME Marseille France Institut Hospitalo-Universitaire (IHU)—Méditerranée Infection Marseille France

Background: Several artemisinin-based combination therapies (ACT) are available to treat uncomplicated malaria in Africa. The present study aimed to assess the ranking of their efficacy and tolerance. Methods: A database of randomized controlled trials was retrieved from published papers. network meta-analysis was used to compare efficacy on day 28 and day 42 after initiation of treatment. Age covariate effect on treatment outcome was assessed, and a modeling approach to reduce heterogeneity among trials was evaluated under the hypothesis of consistency in a meta-regression. Safety and adverse events were compared among different ACTs. A Bayesian analysis was performed to implement the consistency models using WinBUGS software. The results were compared to those of the frequentist approach using the R software. Results: Eighty-one articles, in which a total of 15 different ACTs were tested in more than 36,000 patients, were included. On day 28, dihydroartemisinin-piperaquine (DHPP) was more effective than artemether-lumefantrine (AL) before (odds ratio [OR], 1.83;95% confidence interval [CI], 1.31 - 2.56) and after age-covariate adjustment (OR, 1.70;95% CI, 1.20 - 2.43). The result was similar on day 42. DHPP occupied the top rank. The risk of having cough, diarrhoea or headache post-treatment was significantly lower with DHPP than AL. Artesunate-mefloquine (ASMQ) was associated with a significantly lower prevalence of vomiting or nausea (OR, 0.80;95% CI, 0.48 - 1.30) and headache (OR, 0.53;95% CI, 0.40 - 0.68) compared to AL. On the contrary, vomiting and nausea occurred more frequently after fixed-dose artesunate-amodiaquine formulation (ASAQf) than with AL (OR, 1.45;95% CI, 1.18 - 1.78). The risk of anaemia was higher with ASAQf and co-blistered artesunate-amodiaquine (ASAQc) than with AL. There was no significant difference in risk of anaemia (P > 0.05) between AL and different formulations of ASAQ. Conclusions: Based on the available evidence, this study demons

关键词： Malaria Dihydroartemisinin-Piperaquine Artesunate-Amodiaquine Efficacy Safety network meta-analysis

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Efficacy of various endoscopic modalities in detecting dysplasia in ulcerative colitis:A systematic review and network meta-analysis

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World Journal of Gastrointestinal Endoscopy 2020年第5期12卷 159-171页

作者： Bilal Gondal Haider Haider Yuga Komaki Fukiko Komaki Dejan Micic David T Rubin Atsushi Sakuraba Section of Gastroenterology Hepatology and NutritionDepartment of MedicineThe University of Chicago MedicineChicagoIL 60637United States Section of Gastroenterology Carle HospitalUniversity of IllinoisUrbanaIL 61801United States Digestive and Lifestyle Diseases Kagoshima University Graduate School of Medical and Dental SciencesKagoshima 890-8544Japan

BACKGROUND Longstanding ulcerative colitis(UC)is associated with an increased risk of colonic *** endoscopic modalities,such as chromoendoscopy(CE),narrow band imaging(NBI)and random biopsy have been introduced for surveillance,however,there exists a paucity of direct comparisons between *** aimed to conduct a network meta-analysis of randomized controlled trials(RCTs)performed for surveillance of neoplasia in *** To provide a comparative evaluation of the efficacy of the above-mentioned various *** We searched MEDLINE/PubMed,Web of Science,Embase,Google Scholar and Cochrane Central Registry through May 2016 for RCTs evaluating the efficacy of endoscopic modalities for surveillance of neoplasia in *** primary outcomes of interest were dysplasia(low-or high-grade)detection rates per biopsy and per patient,and dysplasia numbers per *** were simultaneously analyzed using a random-effects network meta-analysis under the Bayesian framework to identify the modality with the highest dysplasia detection *** best ranking probability for the dysplasia detection rate was analyzed by surface under the cumulative ranking(SUCRA)*** Six prospective RCTs of a total 1038 patients were *** identified 4 different modalities;white light(WL)high definition(HD)or standard definition(SD),CE HD,and NBI *** dysplasia per biopsy,direct meta-analysis showed superiority of NBI HD over WL HD and CE HD over WL *** meta-analysis demonstrated the rank order of best modality as NBI HD,CE HD,WL HD and WL SD with close SUCRA scores of the first *** dysplasia per patient,direct meta-analyses showed equivocal results between each *** meta-analysis demonstrated the rank order of best modality as WL HD,NBI HD,CE HD and WL SD with small differences of the SUCRA score among the first *** dysplasia numbers per patient,direct meta-analysis showed superiority of CE HD over WL *** meta-analysis

关键词： Ulcerative colitis Surveillance Dysplasia network meta-analysis Endoscopy

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The optimal choice of chemotherapy regimens for patients with relapsed platinum-resistant epithelial ovarian cancer/primary peritoneal/fallopian tube cancer - protocol for a systematic review and network meta-analysis

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TMR Integrative Medicine 2017年第1期1卷 30-36页

作者： Feng-Hua Liu Xiao-Li Zhou Hui-Ting Xiao Jin-Hui Tian Quan Hao Yong Tang National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Medical University Cancer institute and hospital Tianjin China Tianjin center for disease control and prevention Tianjin Medical University Cancer institute and hospital Tianjin China Department of gynecology Cancer TianjinMedical University Cancer institute and hospital Tianjin China Evidence-Based Medicine Center School ofBasic Medical Sciences Lanzhou University Lanzhou China Department of pancreatic cancer Tianjin MedicalUniversity Cancer institute and hospital Tianjin China

Objective： Debulking surgery （residual disease of less than 1 cm） followed by platinum-taxane chemotherapy isthe current standard therapy for patients with epithelial ovarian cancer, primary peritoneal carcinoma and primaryfallopian cancer. But the prognosis remains poor. Several chemotherapy regimens could be selected for patientswith recrudescent cancer. However, the standard second chemotherapy regimen remains a subject of debate. Thepurpose of our study is to carry out a systematic review and network meta-analysis to compare the efficacy andsafety of different regimens for recurrent platinum-resistant ovarian cancer based on existing randomized controlledtrials （RCTs）. Methods and analysis： Medline, EMBASE, Cochrane Library and Cochrane Library databases,Science Citation Index Expanded, Conference Proceedings Citation Index-Science and *** will besystematically searched for eligible studies. Randomized controlled trials （RCT） on chemotherapy, immune therapy,biological therapy, targeted therapy for recurrent platinum-resistant ovarian cancer with multiple outcome measureswill be included. The Cochrane Risk of Bias Tool will be used to assess the quality of included studies. The primaryoutcomes are overall survival and median survival time. The secondary outcomes include the safety and side effectsof these regimens. Direct meta-analysis and network meta-analysis （NMA） will be conducted to compare differentregimens. Conclusion： The results of this network meta-analysis will provide direct and indirect evidence oftreatments for recurrent platinum-resistant ovarian cancer, and it may provide a ranking of the chemotherapyregimens for patients and gynecological oncologists to help them select the best option.

关键词： Epithelial ovarian cancer Chemotherapy network meta-analysis Protocol

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Neurological Recovery and Antioxidant Effects of Curcumin for Spinal Cord Injury in Rats model—A network meta-analysis and Systematic Review

Neurological Recovery and Antioxidant Effects of Curcumin fo...

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第八届中医/中西医结合循证医学方法研讨会

作者：姚敏杨龙王晶孙悦礼囤荣梁王拥军崔学军 Longhua Hospital Shanghai University of Traditional Chinese Medicine lnstitute of Spine Disease Shanghai University of Traditional Chinese Medicine Yueyang College of Clinical Medicine Shanghai University of Traditional Chinese Medicine

Background: Spinal cord injury(SCI) is a devastating condition that often affecs young and healthy individuals all over of the world. The therapeutic efficacy of existingagents is inadequate and some even associated with some side ***: Summarize and critically assess the neurological recovery and antioxidant effects of curcumin for spinal cord injury in rats ***: A search of PUBMED, EMBASE and Chinese databasesfrom their inception date to February 2014. Two reviewers independently selected animal studies that evaluated neurological recovery and antioxidant effects of curcumin compared with empty treatment on laboratory rats withspinat cord injury, extracted data and assessed methodological quality. Pairwise and network meta-analysis were performed by Revman5.1.2 and R. Results: After selection, 8studies with adequate randomization were subjected to our systematic review. 2 studies had a higher methodological quality-Overall,curcum丨nappears to significantly improve the BBB scale(4 studies, n=132, pooled M0=3.09, 95%CI = 3.40 to 4.45, P=0.04) in a random effect model according to high heterogeneity and decrease the MDAusing fixed effect model(4studies, n=56, pooled MD=-1.00, 95% CI =-1.59 to-0.42,P=00008). For the BBB scale, the effect size increased gradually with increasing dosage of curcumin. Moreover the difference between the BBB scale of low-dose curcumin and high-dose curcumin were statistically significant. Conclusion: Neurological recovery and antioxidant effects of curcumin for spinal cord injury in rats model could be proved despited the poor methodological quality. However, a public methodological quality assessment checklists about animal studies is needed while the assessment of methodological quality should be valued in systematic reviews about animal studies.

关键词： systematic review network meta-analysis spinal cord injury curcumin

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Analgesic effects of different acupuncture therapies on postherpetic neuralgia:a Bayes⁃ian network meta-analysis

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中国药理学与毒理学杂志 2023年第S1期37卷 72-72页

作者： CUI Yang SUN Zhongren ZHOU Xinyu ZHANG Shuo YIN Hongna Heilongjiang University of Chinese Medicine Harbin 150040China The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine Harbin 150001China

OBJECTIVE To assess the effi⁃cacy and safety of acupuncture-related treat⁃ments for postherpetic neuralgia(PHN),identify the most effective acupuncture and related treat⁃*** PubMed,Cochrane Central Register of Controlled Trials,Embase,Web of Science,and four Chinese databases,a clinical research registration platform,and grey literature were *** evaluated the risk of bias and quality in the included studies and per⁃formed a Bayesian multiple network *** We included 29 randomized controlled trials comprising 1973 patients,of which approximately 17.24%showed a high risk of *** to the Jadad scale,2,16,and 11 studies were high,medium,and low quality,*** pairwise meta-analysis results revealed that the efficacy of all acupuncture-related treatments for pain relief related to PHN showed the difference was statistically significant com⁃pared with that of *** network meta-analysis results showed that pricking and cupping plus antiepileptics were the most effective,followed by electroacupuncture(EA)plus antiepileptics for pain relief in patients with *** plus antiepileptics ranked the best regarding reduced Pittsburgh Sleep Quality Index and Self-Rating Depression Scale scores in patients with *** results were found regarding total response rate or quality of life among this ***-related treatments showed a lower incidence of adverse events than that of antiepi⁃leptics-related *** Acu⁃puncture-related therapies may be potential treat⁃ment options for PHN and are relatively *** and cupping plus antiepileptics are the most effective techniques for pain *** plus antiepileptics is the best approach for improving insomnia and depression symptoms of PHN.

关键词： acupuncture acupuncture analge⁃sia postherpetic neuralgia systematic review network meta-analysis

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Optimization ratio between Coptis chinensis and cinnamo of Jiaotai pill plus benzodiazepines for insomnia in China:a network meta-analysis

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中国药理学与毒理学杂志 2021年第10期35卷 737-737页

作者： SUN Shi-guang WANG Qun CHEN Li-jing Department of Pharmacy Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250001China Department of Pharmacy Shandong Provincial Hospital of Integrated MedicineJinan 250001China Department of Vertigo Jinan Shizhong People′s HospitalJinan 250022China

OBJECTIVE To explore the efficacy of Jiaotai pill(JTW)and JTW modified prescriptions(JTW^(+))plus benzodiazepines(BDZ)for insomnia in China by systematic review and network meta-analysis,especially optimization ratio(_(m:n))between Coptis chinensis and *** Randomized controlled trials(RCTs)regarding JTW and JTW^(+)+BDZ for insomina were comprehensively searched in CNKI,VIP,Wanfang,and PubMed,Cochrane Library,OVID,Embase databases from their inception to December *** risk of bias was assessed by the Cochrane collaboration′s tool and Jadad *** review and network meta-analysis were performed to evaluate the relative risk(RR)plus 95%confidence interval(95%CI)or prediction interval(95%PrI),and draw surface under the cumulative ranking curves(SUCRA)by Stata 14.0 and RevMan 5.0 *** A total of 13 RCTs(1 RCT was omitted by sensitivity analysis)with 1040 patients were *** heterogeneity was acceptable,except publication *** on classical meta-analysis,JTW and JTW_(m:n)^(+)+BDZ,such as JTW_(2:1)^(+)+BDZ,JTW_(5:1)^(+)+BDZ,JTW_(6:1)^(+)+BDZ,JTW_(10:1)^(+)+BDZ,had more efficacy than *** on network meta-analysis,JTW and JTW_(m:n)^(+)+BDZ,such as JTW_(2:1)^(+)+BDZ,JTW_(6:1)^(+)+BDZ,JTW_(10:1)^(+)+BDZ,had more efficacy than BDZ;meanwhile,SUCRA showed the best rank of JTW/JTW+(BDZ

关键词： Jiaotai pill Coptis chinensis cinnamo ratio insomnia randomized controlled trial systematic review network meta-analysis

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