Neurological Recovery and Antioxidant Effects of Curcumin for Spinal Cord Injury in Rats model—A Network Meta-Analysis and Systematic Review
作者单位：Longhua Hospital Shanghai University of Traditional Chinese Medicine lnstitute of Spine Disease Shanghai University of Traditional Chinese Medicine Yueyang College of Clinical MedicineShanghai University of Traditional Chinese Medicine
会议名称：《第八届中医/中西医结合循证医学方法研讨会》
会议日期：2014年
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
关 键 词：systematic review network meta-analysis spinal cord injury curcumin
摘 要：Background: Spinal cord injury(SCI) is a devastating condition that often affecs young and healthy individuals all over of the world. The therapeutic efficacy of existingagents is inadequate and some even associated with some side ***: Summarize and critically assess the neurological recovery and antioxidant effects of curcumin for spinal cord injury in rats ***: A search of PUBMED, EMBASE and Chinese databasesfrom their inception date to February 2014. Two reviewers independently selected animal studies that evaluated neurological recovery and antioxidant effects of curcumin compared with empty treatment on laboratory rats withspinat cord injury, extracted data and assessed methodological quality. Pairwise and network meta-analysis were performed by Revman5.1.2 and R. Results: After selection, 8studies with adequate randomization were subjected to our systematic review. 2 studies had a higher methodological quality-Overall,curcum丨nappears to significantly improve the BBB scale(4 studies, n=132, pooled M0=3.09, 95%CI = 3.40 to 4.45, P=0.04) in a random effect model according to high heterogeneity and decrease the MDAusing fixed effect model(4studies, n=56, pooled MD=-1.00, 95% CI =-1.59 to-0.42,P=00008). For the BBB scale, the effect size increased gradually with increasing dosage of curcumin. Moreover the difference between the BBB scale of low-dose curcumin and high-dose curcumin were statistically significant. Conclusion: Neurological recovery and antioxidant effects of curcumin for spinal cord injury in rats model could be proved despited the poor methodological quality. However, a public methodological quality assessment checklists about animal studies is needed while the assessment of methodological quality should be valued in systematic reviews about animal studies.