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Implantable nerve guidance conduits:Material combinations,multi-functional strategies and advanced engineering innovations

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Bioactive Materials 2022年第5期7卷 57-76页

作者： Yixin Yan Ruotong Yao Jingyuan Zhao Kaili Chen Lirong Duan Tian Wang Shujun Zhang Jinping Guan Zhaozhu Zheng Xiaoqin Wang Zekun Liu Yi Li Gang Li National Engineering Laboratory for Modern Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhou215123China Department of Materials University of ManchesterOxford RoadManchesterM139PLUK Department of Materials Imperial College LondonSW72AZUK Wilson College of Textiles North Carolina State UniversityRaleigh27695USA Research Centre of Printed Flexible Electronics School of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen518055China

nerve guidance conduits(NGCs)have attracted much attention due to their great necessity and applicability in clinical use for the peripheral nerve *** efforts in recent years have been devoted to the development of high-performance NGCs using various materials and *** present review provides a comprehensive overview of progress in the material innovation,structural design,advanced engineering technologies and multi functionalization of state-of-the-art nerve guidance conduits *** advanced engineering technologies including extrusion-based system,laser-based system,and novel textile forming techniques in terms of weaving,knitting,braiding,and electrospinning techniques were also analyzed in *** arising from this review indicate that the structural mimetic NGCs combined with natural and synthetic materials using advanced manufacturing technologies can make full use of their complementary advantages,acquiring better biomechanical properties,chemical stability and ***,the existing challenges and future opportunities of NGCs were put forward aiming for further research and applications of NGCs.

关键词： nerve guidance conduits Micro-nanofibers Multi-functional Surface modification Microenvironment

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Human umbilical cord mesenchymal stem cell-derived exosomes loaded into a composite conduit promote functional recovery after peripheral nerve injury in rats

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Neural Regeneration Research 2024年第4期19卷 900-907页

作者： Haoshuai Tang Junjin Li Hongda Wang Jie Ren Han Ding Jun Shang Min Wang Zhijian Wei Shiqing Feng Department of Othopaedics Tianjin Medical University General Hospital International Science and Technology Cooperation Base of Spinal Cord Injury Tianjin Key Laboratory of Spine and Spinal Cord InjuryDepartment of OrthopedicsTianjin Medical University General Hospital Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Tianjin Lung Cancer InstituteTianjin Medical University General Hospital Department of Othopaedics Qilu Hospital of Shandong UniversityShandong University Centre for OthopedicsAdvanced Medical Research InstituteShandong University Orthopedic Research Center of Shandong University&Advanced Medical Research Institute Cheeloo College of MedicineShandong University

Complete transverse injury of peripheral nerves is challenging to *** secreted by human umbilical cord mesenchymal stem cells are considered to play an important role in intercellular communication and regulate tissue *** previous studies,a collagen/hyaluronic acid sponge was shown to provide a suitable regeneration environment for Schwann cell proliferation and to promote axonal *** three-dimensional(3D)composite conduit contains a collagen/hyaluronic acid inner sponge enclosed in an electrospun hollow poly(lactic-co-glycolic acid)***,whether there is a synergy between the 3D composite conduit and exosomes in the repair of peripheral nerve injury remains *** this study,we tested a comprehensive strategy for repairing long-gap(10 mm)peripheral nerve injury that combined the 3D composite conduit with human umbilical cord mesenchymal stem cell-derived *** effectiveness was evaluated by sciatic functional index,sciatic nerve compound muscle action potential recording,recovery of muscle mass,measuring the cross-sectional area of the muscle fiber,Masson trichrome staining,and transmission electron microscopy of the regenerated nerve in *** results showed that transplantation of the 3D composite conduit loaded with human umbilical cord mesenchymal stem cell-derived exosomes promoted peripheral nerve regeneration and restoration of motor function,similar to autograft *** CD31-positive endothelial cells were observed in the regenerated nerve after transplantation of the loaded conduit than after transplantation of the conduit without exosomes,which may have contributed to the observed increase in axon regeneration and distal nerve ***,the use of a 3D composite conduit loaded with human umbilical cord mesenchymal stem cell-derived exosomes represents a promising cell-free therapeutic option for the treatment of peripheral nerve injury.

关键词： axon growth collagen exosome human umbilical cord mesenchymal stem cells hyaluronic acid muscular atrophy nerve guidance conduits peripheral nerve regeneration

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Micropatterns and peptide gradient on the inner surface of a guidance conduit synergistically promotes nerve regeneration in vivo

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Bioactive Materials 2022年第3期7卷 134-146页

作者： Deteng Zhang Ziming Li Haifei Shi Yuejun Yao Wang Du Pan Lu Kejiong Liang Liangjie Hong Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou310058China Department of Hand Surgery First Affiliated Hospital of Zhejiang UniversitySchool of Medicine.Hangzhou310009China

Both of the surface topographical features and distribution of biochemical cues can influence the cell-substrate interactions and thereby tissue regeneration in ***,they have not been combined simultaneously onto a biodegradable scaffold to demonstrate the synergistic role so *** this study,a proof-of-concept study is performed to prepare micropatterns and peptide gradient on the inner wall of a poly(D,L-lactide-co-caprolactone)(PLCL)guidance conduit and its advantages in regeneration of peripheral nerve in *** linear ridges/grooves of 20/40μm in width are created on the PLCL film,its surface is aminolyzed in a kinetically controlled manner to obtain the continuous gradient of amino groups,which are then transferred to CQAASIKVAV peptide density gradient via covalent coupling of *** Schwann cells are better aligned along with the stripes,and show a faster migration rate toward the region of higher peptide *** of the nerve guidance conduit made of the PLCL film having both the micropatterns and peptide gradient can significantly accelerate the regeneration of sciatic nerve in terms of rate,function recovery and microstructures,and reduction of fibrosis in muscle ***,this nerve conduit can also benefit the M2 polarization of macrophages and promote vascularization in vivo.

关键词： Peptides gradient Micropatterns Contact guidance effect nerve guidance conduits nerve regeneration

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Surgical repair of a 30-mm-long human median nerve defect in the distal forearm by implantation of a chitosan/PGA nerve guidance conduit:a case study

Surgical repair of a 30-mm-long human median nerve defect in...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Wen HU~1,Jian-Hui GU~2,Ai-Dong DENG~2,Xiao-Song GU~(1,*) 1 Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Nantong,226001 2 Department of Hand Surgery,Affiliated Hospital of Nantong University,Nantong,226001

Reconstruction of injured peripheral nerve by bridging neural defects with artificial nerve guidance conduits (NGCs),as an alternative to autologous nerve grafts,becomes one of the main concerns in the fields of microsurgery, plastic surgery,and regenerative *** have developed a novel design of artificial NGCs consisting of a chitosan conduit and longitudinally aligned filaments of polyglycolic acid(PGA) inserted in the conduit *** chitosan/PGA NGCs showed good biological properties,and yielded promising repair outcomes after they were used to bridge canine sciatic nerve defects as long as 30 *** also reported a case study in which a 35-mm-long human median nerve defect at elbow was repaired by the chitosan/PGA *** we describe another clinical case study in which a chitosan/PGA NGC was utilized to repair a 30-mm-long median nerve defect in the distal forearm of a 55-year-old ***-six months post-implantation,the function of the right abductor pollicis and opponens pollicis recovered to an M4 level. Static two-point discrimination measured 14,9,and 9 mm in the thumb,index and middle fingers of the right hand, indicating a S3 level sensory recovery for the injured median *** compound muscle action potentials were recorded on the right abductor *** ninnydrin test showed partial recovery in perspiration of the injured thumb,index and middle *** repair case suggests a potential strategy for clinical reconstruction of extended defects in peripheral nerve trunks by implantation of chitosan/PGA NGCs.

关键词： nerve injury peripheral nerve surgery median nerve nerve guidance conduits chitosan polyglycolic acid

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