Implantable nerve guidance conduits:Material combinations,multi-functional strategies and advanced engineering innovations

作     者：Yixin Yan Ruotong Yao Jingyuan Zhao Kaili Chen Lirong Duan Tian Wang Shujun Zhang Jinping Guan Zhaozhu Zheng Xiaoqin Wang Zekun Liu Yi Li Gang Li 

作者机构：National Engineering Laboratory for Modern SilkCollege of Textile and Clothing EngineeringSoochow UniversitySuzhou215123China Department of MaterialsUniversity of ManchesterOxford RoadManchesterM139PLUK Department of MaterialsImperial College LondonSW72AZUK Wilson College of TextilesNorth Carolina State UniversityRaleigh27695USA Research Centre of Printed Flexible ElectronicsSchool of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen518055China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第5期

页      面：57-76页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：financially supported by National Key R&D Program of China(2021YFE0111100 and 2019YFE0117700) the“Top six talent peaks”program of Jiangsu(GDZB-035)and Science and Technology Project of Nantong(JC2020082) the support of China National Textile and Apparel Council(J202002) joint scientific research project of Sino-foreign cooperative education platform of Jiangsu Higher Education Institutions(5011500720) projects with numbers FZ20190257,XJFZ/2021/7 and 2021fx010104 

主　　题：Nerve guidance conduits Micro-nanofibers Multi-functional Surface modification Microenvironment 

摘      要：Nerve guidance conduits(NGCs)have attracted much attention due to their great necessity and applicability in clinical use for the peripheral nerve *** efforts in recent years have been devoted to the development of high-performance NGCs using various materials and *** present review provides a comprehensive overview of progress in the material innovation,structural design,advanced engineering technologies and multi functionalization of state-of-the-art nerve guidance conduits *** advanced engineering technologies including extrusion-based system,laser-based system,and novel textile forming techniques in terms of weaving,knitting,braiding,and electrospinning techniques were also analyzed in *** arising from this review indicate that the structural mimetic NGCs combined with natural and synthetic materials using advanced manufacturing technologies can make full use of their complementary advantages,acquiring better biomechanical properties,chemical stability and ***,the existing challenges and future opportunities of NGCs were put forward aiming for further research and applications of NGCs.