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Development of a novel multi-functional integrated bioconjugate effectively targeting K-Ras mutant pancreatic cancer

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Journal of Pharmaceutical Analysis 2022年第2期12卷 232-242页

作者： Yang-Yang Wang Liang Li Xiu-Jun Liu Qing-Fang Miao Yi Li Meng-Ran Zhang Yong-Su Zhen Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin300060China NHC Key Laboratory of Biotechnology of Antibiotics Department of OncologyInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(Pmulti-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer.

关键词： Pancreatic cancer Folate receptor multi-functional Macropinocytosis-enhanced Bioconjugate K-Ras PEGylation

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Implantable nerve guidance conduits:Material combinations,multi-functional strategies and advanced engineering innovations

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Bioactive Materials 2022年第5期7卷 57-76页

作者： Yixin Yan Ruotong Yao Jingyuan Zhao Kaili Chen Lirong Duan Tian Wang Shujun Zhang Jinping Guan Zhaozhu Zheng Xiaoqin Wang Zekun Liu Yi Li Gang Li National Engineering Laboratory for Modern Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhou215123China Department of Materials University of ManchesterOxford RoadManchesterM139PLUK Department of Materials Imperial College LondonSW72AZUK Wilson College of Textiles North Carolina State UniversityRaleigh27695USA Research Centre of Printed Flexible Electronics School of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen518055China

Nerve guidance conduits(NGCs)have attracted much attention due to their great necessity and applicability in clinical use for the peripheral nerve repair.Great efforts in recent years have been devoted to the development of high-performance NGCs using various materials and strategies.The present review provides a comprehensive overview of progress in the material innovation,structural design,advanced engineering technologies and multi functionalization of state-of-the-art nerve guidance conduits NGCs.Abundant advanced engineering technologies including extrusion-based system,laser-based system,and novel textile forming techniques in terms of weaving,knitting,braiding,and electrospinning techniques were also analyzed in detail.Findings arising from this review indicate that the structural mimetic NGCs combined with natural and synthetic materials using advanced manufacturing technologies can make full use of their complementary advantages,acquiring better biomechanical properties,chemical stability and biocompatibility.Finally,the existing challenges and future opportunities of NGCs were put forward aiming for further research and applications of NGCs.

关键词： Nerve guidance conduits Micro-nanofibers multi-functional Surface modification Microenvironment

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multi-functional optical fiber sensor system based on a dense wavelength division multiplexer

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Chinese Physics B 2019年第7期28卷 222-224页

作者：尹悦鑫吴志发孙思文田亮王希斌吴远大张大明 State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changchun 130012 China State Key Laboratory of Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 China

We propose a novel and efficient multi-functional optical fiber sensor system based on a dense wavelength division multiplexer(DWDM).This system consists of an optical fiber temperature sensor, an optical fiber strain sensor, and a 48-channel DWDM.This system can monitor temperature and strain changes at the same time.The ranges of these two sensors are from-20℃ to 100℃ and from-1000 με to 2000 με, respectively.The sensitivities of the temperature sensor and strain sensor are 0.03572 nm/℃ and 0.03808 nm/N, respectively.With the aid of a broadband source and spectrometer,different kinds and ranges of parameters in the environment can be monitored by using suitable sensors.

关键词： dense wavelength division multiplexer(DWDM) planar lightwave circuit multi-functional sensor optical fiber sensor system

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Analysis of Dynamic Cross Response between Spindles in a Dual Spindle Type multi-functional Turning Machine

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Journal of Power and Energy Engineering 2013年第7期1卷 20-24页

作者： Y. H. Choi S. T. Kim T. Y. Seo K. H. Kim 1Department of Mechanical Engineering Changwon National University Changwon Korea 2Department of Mechanical Design Engi-neering Graduate School of Changwon National University Changwon Korea 3Technology Research Institute AMECO Co. Ltd. Korea. Department of Mechanical Engineering Changwon National University Changwon Korea 2Department of Mechanical Design Engi-neering Graduate School of Changwon National University Changwon Korea 3Technology Research Institute AMECO Co. Ltd. Korea.

In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining processes on one machine, have been developed and widely used in manufacturing industries. In this study, a multi-functional turning lathe, which has two spindles and two turrets so that multiple turning operations and various machining processes could be performed simultaneously, has been developed. Furthermore, the equations of correlation between whole responses and cross responses of the two spindles have been derived to examine to what extent the two spindles affect each other’s vibrations.

关键词： multi-functional Lathe multi-Spindles Frequency Response Cross Response FEM Structural Analysis

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Design and Development of a multi-functional Laparoscopic Device

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Journal of Mechanics Engineering and Automation 2019年第5期9卷 173-176页

作者： Tugrul Tansug Elif Taskin Eray Kurt Meltem Elitas General Surgeon Adatip Istanbul Private HospitalIstanbul 34912Turkey Mechatronics Program Faculty of Engineering and Natural SciencesIstanbul 34956Turkey

This study presents a design of a multifunctional laparoscopic appendectomy device that includes three surgical instruments commonly used in laparoscopic appendicitis surgeries:endoloop,endobag and scissors.It collects these three independent surgical tools in a single laparoscopic appendectomy device.These days there is a trend of moving to multi-functional surgery devices during minimally invasive surgery.The main reasons behind the minimal invasive surgery are to avoid changing the devices several times during the operation,to reduce the time spent in operation,to increase the efficiency of the operation,to facilitate the follow-up of the camera and devices,and to leave trocars to be used for other surgical instruments.The multi-functional appendectomy device that,we present here,provides these benefits.The standard trocar entries are appropriate for its usage.The presented multifunctional laparoscopic appendectomy device offers more practical use in comparison to individual devices.On the other hand,development of these multi-functional surgery devices can be directly enhanced to the robotic surgery devices.

关键词： Apendectomy multi-functional laparoscopy SolidWorks surgery

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Plant-leaf-inspired MXene-silk composite for intelligent solar steam generation combined with mechanical actuation

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Nano Research 2023年第5期16卷 7792-7800页

作者： Yongqiang Qian Zhiling Luo Yi Wang Wei Zhang Luzhuo Chen Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials College of Physics and EnergyFujian Normal UniversityFuzhou 350117China Fujian Provincial Collaborative Innovation Center for Advanced High-Field Superconducting Materials and Engineering Fuzhou 350117China Fujian Provincial Engineering Technology Research Center of Solar Energy Conversion and Energy Storage Fuzhou 350117China

Solar steam generators based on photothermal materials are important in producing fresh water.However,conventional solar steam generators are difficult to self-adapt to the complex external environment as organisms.Herein,inspired by the plant leaf,we propose a photothermal composite based on MXene and silk to add more functionality.On one hand,the composite achieves an evaporation rate of 1.51 kg·m^(−2)·h^(−1)and a conversion efficiency of 86.9%under a solar intensity of 1 kW·m^(−2),mimicking the water transpiration of plant leaf.On the other hand,the MXene-silk-based actuator shows a maximum bending curvature of 0.91 cm^(−1)under a solar intensity of 5 kW·m^(−2).Furthermore,an intelligent solar system is constructed utilizing the synergy of solar steam generator and actuator,which advances the research from the material level to the system level.Mimicking the behavior of plant leaf,the system can automatically open during the day to generate steam and fresh water.And at night or in bad weather,it will automatically close to prevent external pollution such as dust,achieving intelligent anti-fouling.This research will have good application prospects in less developed areas.Meanwhile,it also provides a certain reference value for exploring multi-functional photothermal devices in the future.

关键词： MXene silk solar steam generator photothermal actuator multi-functional

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High areal capacity flexible sulfur cathode based on multi-functionalized super-aligned carbon nanotubes

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Nano Research 2019年第5期12卷 1105-1113页

作者： Lujie Jia Jian Wang Zijin Chen Yipeng Su Wei Zhao Datao Wang Yang Wei Kaili Jiang Jiaping Wang Yang Wu Jia Li Wenhui Duan Shoushan Fan Yuegang Zhang State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China i-Lab Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Laboratory for Computational Materials Engineering Division of Energy and Environment Graduate School at ShenzhenTsinghua UniversityShenzhen 518055China

Rational design of a robust carbon matrix has a profound impact on the performance of flexible/wearable lithium/sulfur batteries.Herein,we demonstrate a freestanding three-dimensional super-aligned carbon nanotube (SACNT) matrix reinforced with a multi-functionalized carbon coating for flexible,high-areal sulfur loading cathode.By employing the sulfur/nitrogen co-doped carbon (SNC)"glue",the joints in the SACNT scaffold are tightly welded together so that the overall mechanical strength of the electrode is significantly enhanced to withstand the repeated bending as well as the volume change during operation.The SNC also shows intriguing catalytic effect that lowers the energy barrier of Li ion transport,propelling a superior redox conversion efficiency.The resulting binder-free and current collector-free sulfur cathode exhibits a high reversible capacity of 1,079 mAh·g^-1 at 1 C,a high-rate capacity of ~ 800 mAh·g^-1 at 5 C,and an average capacity decay rate of 0.037% per cycle at 2 C for 1,500 cycles.Impressively,a large-areal flexible Li/S pouch cell based on such mechanically robust cathode exhibits excellent capacity retention under arbitrary bending conditions.With a high areal sulfur loading of 7 mg·cm^-2,the large-areal flexible cathode delivers an outstanding areal capacity of 6.3 mAh·cm^-2 at 0.5 C (5.86 mA·cm^-2),showing its promise for realizing practical high energy density flexible Li/S batteries.

关键词： lithium/sulfur battery flexible electrode multi-functional carbon glue high areal capacity

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Design and Implementation of multi-functional Digital Servos Control System

Design and Implementation of Multi-functional Digital Servos...

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第30届中国控制与决策会议

作者： Houde Liu Kangkang Dong Xiaojun Zhu Xueqian Wang Bin Liang Tsinghua University Graduate School at Shenzhen School of Automation Beijing University of Posts and Telecommunications Research Institute of Tsinghua University in Shenzhen

This paper designs a scheme of multi-functional digital servos control system based on STM32. The basic functions of each module are described;the hardware and software structure and working principle of the system are analyzed. In the system three working modes which are Motor mode, Servo mode and Wait mode are provided. There are wired and wireless communication modes between the master chip and PC. The master chip uses a typical PID algorithm to process the position information that is read by contactless magnetic rotary encoder and output the corresponding PWM to control the position and speed of the servos precisely.

关键词： Digital servos multi-functional STM32 Contactless magnetic encoder PID algorithm

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Polymer-based ?exible bioelectronics

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Science Bulletin 2019年第9期64卷 634-640页

作者： Xiaoying Wu Huisheng Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Scienceand Laboratory of Advanced MaterialsFudan University

Due to the mechanical mismatch between conventional rigid electronic devices and soft tissues at nature,a lot of interests have been attracted to develop flexible bioelectronics that work well both in vitro and in vivo. To this end, polymers that can be used for both key components and substrates are indispensable to achieve high performances such as high sensitivity and long-term stability for sensing applications.Here we will summarize the recent advances on the synthesis of a variety of polymers, the design of typical architectures and the integration of different functions for the flexible bioelectronic devices. The remaining challenges and promising directions are highlighted to provide inspirations for the future study on the emerging flexible bioelectronics at end.

关键词： Polymer Flexible Stretchable multi-functional Bioelectronic device

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Recent advances in the development of activatable multifunctional probes for in vivo imaging of caspase-3

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Chinese Chemical Letters 2021年第1期32卷 168-178页

作者： Pengzhan Wang Huocheng Yang Chang Liu Mingqiang Qiu Xin Ma Zhiqiang Mao Yao Sun Zhihong Liu Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules&College of Chemistry and Chemical EngineeringHubei UniversityWuhan 430062China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaXinjiang Medical UniversityXinjiang 830011China International Joint Research Center for Intelligent Biosensor Technology and Health Key Laboratory of Pesticides and Chemical BiologyMinistry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Caspases are a family of proteases that play critical roles in controlling inflammation and cell death.Apoptosis is a caspase-3 mainly controlled behavior to avoid inflammation and damage to surrounding cells,whereas anomalistic cell apoptosis may be associated with many diseases.The detection and imaging of caspase-3 will be of great significance in evaluating the early therapeutic effect of tumors.Developing smart fluorescent probes may be helpful for the visualization of the rapeutic effect compared with "always on" probes.Thus,more and more works toward activatable fluorescent probes for caspase-3 imaging have been reported.In addition,multifunctional probes have also been designed to further improve the imaging of caspase-3.Herein,this review systematically summarized the representative wo rk of caspase-3 from the perspective of molecular design that it will play a guiding role in the design of probes that respond to caspase-3.Also,challenges and perspectives toward the field for imaging of cell apoptosis(caspase-3) are also discussed.

关键词： Fluorescence imaging multi-functional Activatable probe Caspase-3

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