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Novel insights into necrozoospermia from a single-center study:reference ranges,possible etiology,and impact on male fertility

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Asian Journal of Andrology 2024年第5期26卷 528-534页

作者： Er-Chen Zhang Xin-Yu Yin Zi-Yan Peng Zhi-Zhou Lai Liang Hu Yang-Qin Peng Huan Zhang Rui Ming Ge Lin Wei-Na Li NHC Key Laboratory of Human Stem Cell and Reproductive Engineering School of Basic Medical SciencesCentral South UniversityChangsha 410008China Laboratory of Zebrafish Genetics College of Life SciencesHunan Normal UniversityChangsha 410006China Hunan Guangxiu Hospital School of MedicineHunan Normal UniversityChangsha 410001China Clinical Research Center for Reproduction and Genetics in Hunan Province Reproductive and Genetic Hospital of CITICXiangyaChangsha 410008China Hunan International Scientific and Technological Cooperation Base of Development and Carcinogenesis Changsha 410008China Hunan Guangxiu Hi-tech Life Technology Co. Ltd.Changsha 410013China

necrozoospermia is a poorly documented condition with a low incidence,and its definition and clinical significance are ***,we provide a reference range for necrozoospermia and discuss its possible etiology and impact on male fertility and assisted reproductive *** extracted relevant information from 650 Chinese male partners of infertile couples and statistically analyzed sperm *** was present in 3.4%(22/650)of our study population,and the lower cut-off value for sperm vitality was 75.3%.We compared two methods for assessing sperm vitality(eosin-nigrosin head staining and hypo-osmotic swelling test[HOST]),for which the percentage in the eosin-nigrosin group(mean±standard deviation[s.d.]:77.5%±10.5%)was significantly higher than that in the HOST group(mean±s.d.:58.1%±6.7%[5-10 min after incubation]and 55.6%±8.2%[25-30 min after incubation];both Pnecrozoospermia increased with age(odds ratio[OR]=1.116,95%confidence interval[CI]:1.048-1.189,P=0.001),while the percentage of normal sperm morphology and DNA fragmentation index(DFI)were significantly associated with necrozoospermia,with ORs of 0.691(95%CI:0.511-0.935,P=0.017)and 1.281(95%CI:1.180-1.390,Pnecrozoospermia group and 87 patients in the necrozoospermia group to compare intracytoplasmic sperm injection(ICSI)and pregnancy outcomes between the two *** necrozoospermia group had a significantly lower normal fertilization rate(74.7%vs 78.2%,P=0.041;OR=0.822;95%CI:0.682-0.992)than that in the nonnecrozoospermia *** study presents substantial information on necrozoospermia to establish comprehensive and applicable reference values for sperm vitality for spontaneous conception and artificially assisted reproductive management.

关键词： male fertility necrozoospermia reference ranges sperm vitality

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Absence of sperm meiotic segregation error of chromosomes 1, 9,12,13,16,18, 21, X and Y in a case of 100% necrozoospermia

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Asian Journal of Andrology 2003年第2期5卷 163-166页

作者： Ashutosh Halder Vandana Chaddha Savita Agarwal Ashish Fauzdar Department of Medical Genetics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow IndiaDepartment of Medical Genetics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow IndiaDepartment of Medical Genetics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow IndiaDepartment of Medical Genetics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India

Varying degrees of necrozoospermia are common findings in cases of male sub-fertility; however, it is rare to find persistent and 100 % necrozoospermia. A case of persistent 100 % necrozoospermia is presented in this paper, where aneuploidy analysis was carried out on sperm. No known associations like thyrotoxicosis, genital infection, spinal injury and diabetes were found. Sperm fluorescent in situ hybridization (FISH) was carried out to evaluate sperm aneuploidy for chromosome 1, 9, 12, 13, 16, 18, 21, X and Y and did not show any excess of aneuploidy over controls. To the best of our knowledge, this is the first attempt on meiotic segregation analysis on 100 % necrozoospermic patient.

关键词： oligospermia necrozoospermia fluorescent in situ hybridization

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