检索结果-南通市图书馆

Practical,regulatory and clinical considerations for development of inhalation drug products

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2015年第6期10卷 490-500页

作者： Shuguang Hou Jiangyue Wu Xu Li Hong Shu Sichuan Purity Pharmaceutical Technology Co. Ltd3-1 Jiuxing AveHi-Tech ZoneChengduSichuan 610041China

The formulation and device collectively constitute an inhalation drug *** of inhaled drugs must consider the compatibility between formulation and device in order to achieve the intended pharmaceutical performance and usability of the product to improve patient compliance with treatment *** the points of formulation,device and patient use,this article summarizes the inhalation drugs,including pressurized metered dose inhaler(pMDI),dry powder inhaler(DPI),and nebulizer that are currently available in the US and UK *** also discusses the practical considerations for the development of inhalers and provides an update on the corresponding regulations of the FDA(*** and Drug Administration)and the EMA(European Medicines Agency).

关键词： Pressurized metered dose inhaler(pMDI) Dry powder inhaler(DPI) nebulizer Formulation Device Clinical application

An aerosol formulation of R-salbutamol sulfate for pulmonary inhalation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2014年第1期4卷 79-85页

作者： Xuemei Zhang Qing Liu Junhua Hu Ling Xu Wen Tan School of Bioscience and Bioengineering South China University of TechnologyGuangzhou 510006China Key-Pharma Biomedical Inc. Dongguan 523000China

An aerosol formulation containing 7.5 mg of R-salbutamol sulfate was *** aerosol was nebulized with an air-jet nebulizer,and further assessed according to the new European Medicines Agency(EMA)guidelines.A breath simulator was used for studies of delivery rate and total amount of the active ingredient at volume of 3 mL.A next generation impactor(NGI)with a cooler was used for analysis of the particle size and in vitro lung deposition rate of the active ingredient at *** anti-asthmatic efficacy of the aerosol formulation was assessed in guinea pigs with asthma evoked by intravenous injection of histamine compared with racemic *** results show that this aerosol formulation of R-salbutamol sulfate met all the requirements of the new EMA guidelines for *** efficacy of a half-dose of R-salbutamol equaled that of a normal dose of racemic salbutamol.

关键词： R-salbutamol nebulizer NGI Particle size Dose uniformity Guinea pigs Asthma

Efficient management and maintenance of ultrasonic nebulizers to prevent microbial contamination

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Methodology 2016年第1期6卷 126-132页

作者： Yoko Ida Hiroaki Ohnishi Kouji Araki Ryoichi Saito Shin Kawai Takashi Watanabe Clinical Laboratory Kyorin University Hospital Department of Microbiology and Immunology Graduate School of Health Care SciencesTokyo Medical and Dental University Department of Laboratory Medicine Kyorin University School of Medicine Department of General Medicine Kyorin University School of Medicine

AIM:To seek the cause of Burkholderia cepacia complex(Bcc) infection outbreak and evaluate the efficacy of new methods for nebulizer maintenance. METHODS: We investigated the annual number of Bcc isolates recovered from clinical samples in our hospital between 1999 and 2013. Swab samples were randomly collected for bacterial culture before patient use from 10 each of the two machine types in August 2001; these included 20 samples from each of the following: Drain tubes, operating water chambers, oscillators, and nebulizing chambers. In addition, 10 samples each of nebulizer solutions before and after use were cultured. For environmental investigation, 10 samples were collected from sinks in the nurse stations of the wards where patients positive for Bcc were hospitalized. Numbers of Bcc isolates were compared before and after introduction of new methods for nebulizer maintenance in October 2001. In addition, randomly amplified polymorphic DNA(RAPD) assay was applied to find the genetic divergence of the Bcc isolates obtained from clinical samples and nebulizers. RESULTS: From January 1999 to December 2013, a total of 487 Bcc isolates were obtained from clinical specimens from 181 patients. Notably, 322(66.1%) Bcc isolates were obtained from clinical specimens from 1999 to 2001, including 244(115 patients) from sputum and 34(11 patients) from blood. During this period, 14 isolates were obtained from nebulizer components. Among these, six were derived from nebulizer drain tubes, five from operating water chambers, and one from the oscillator before patient use, and two from nebulizer solutions after patient use. When Bcc was isolated from the nebulizer solution after patient use, Bcc was simultaneously detected in other parts of the nebulizer. Bcc was not isolated from any nebulizer solution before use. RAPD assays revealed similar DNA profiles in isolates obtained from patients and nebulizers. Investigation revealed damaged diaphragms in many nebulizers. The new main

关键词： Prevention Contamination Burkholderia cepacia Randomly amplified polymorphic DNA assay Ultrasonic nebulizer

Inhalation Devices and Pulmonary Drug Delivery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Nursing Research 2022年第3期6卷 54-72页

作者： Sara M Tony Mohamed EA Abdelrahim Beni-Suef Specialized Hospital Beni-Suef Egypt Clinical Pharmacy Department Faculty of PharmacyBeni-Suef University Beni-SuefEgypt

Inhaled drug delivery is mainly used to treat pulmonary airway disorders by transporting the drug directly to its targeted location for *** decreases the dose required to exert a therapeutic effect and minimizes any potential adverse *** drug delivery to air passages facilitates a faster onset of action;it also minimizes irritation to the stomach,which frequently occurs with oral medications,and prevents the exposure of drugs to pre-systemic metabolism that takes place in the intestine and *** addition to that,the lung is regarded as a route for transporting medications throughout the entire body's blood *** type of medication and the device used to deliver it are both important elements in carrying the drug to its target in the *** types of inhalation methods are used in inhaled *** differ in the dose delivered,inhalation technique,and other *** paper will discuss these factors in more detail.

关键词： Pulmonary drug delivery pMDI,DPI nebulizer

Inhalation therapy for pulmonary fibrosis:chemical medicines and herbal medicines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TMR Modern Herbal Medicine 2023年第3期6卷 31-43页

作者： Xiao-Fen Xie Yao Lu Xu-Shan Chen Gulizeba Muhetaer Hao Tao Hang Li Han-Jiao Liu Central lab Shenzhen Bao’an Chinese Medicine HospitalShenzhen 518000China Nursing department Shenzhen Bao’an Chinese Medicine HospitalShenzhen 518000China Nursing department Shenzhen Hospital of Integrated Traditional Chinese and Western MedicineShenzhen 518000China

Pulmonary fibrosis(PF)is a chronic,progressive,and irreversible pulmonary interstitial disease with unclear ***,there are few treatment options for managing *** therapy,as a routine treatment for respiratory diseases,is being used to study the treatment of *** herbal medicines and their active ingredients have been reported to have anti-PF *** review aims to provide an overview of the latest developments in inhalation therapy,focusing on the utilization of chemical medicines and herbal medicines for the treatment of PF in both clinical practice and basic *** inhalation of chemical drugs such as pirfenidone,nintedanib,N-acetylcysteine,and interferon-γhas been shown to demonstrate anti-PF ***,the inhalation of various natural products derived from herbal medicines,encompassing polyphenols,alkaloids,flavonoids,saponins,terpenoids,and herbal extracts,contributes to the therapeutic management of PF through diverse *** inhalation of both chemical and herbal medicines presents promising advantages in the treatment of *** clinical trials are required to investigate the effectiveness,safety,and mechanism of action of inhalation therapy utilizing natural products derived from herbal medicines.

关键词： herbal medicine nebulizer pulmonary fibrosis natural product inhalation