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En bloc resection concept for endoscopic endonasal nasopharyngectomy： surgical anatomy and outcome

Chinese Medical Journal 2014年第16期127卷 2934-2939页

作者： Hsu Ning-i Shen Ping-hung Chao Siew-shuen Ong Yew-kwang Li Cho-shun Department of Otolaryngology Kuang-Tien General HospitalTaichung Taiwan China Department of Biotechnology Hung-Kuang University TaichungTaiwan China Department of Otolaryngology Head and Neck Surgery National University Hospital Singapore Department of Neurosurgery Chung-Shan Medical UniversityHospital Taichung Taiwan China School of Medicine Chung-Shan Medical University TaichungTaiwan China

Background Nasopharyngeal carcinoma （NPC） patients have a 19%-56% locoregional recurrence rate after primary *** those recurrent NPC （rNPC） patients,re-irradiation may cause some *** recent years,endoscopic endonasal nasopharyngectomy （EEN） has become a surgical option for rNPC *** we introduce the concept of en bloc excision （EBE） technique for EEN,including the surgical technique and clinical *** A retrospective study was conducted covering September 2009 to May 2013,involving the collection of Iocoregional rNPC cases from two institutions （Kuang-Tien General Hospital （KTGH） in Taiwan and National University Health System （NUHS） in Singapore）.These patients failed prior therapy and then underwent *** reported the 2-year overall survival rate,the 2-year disease-free survival rate,and related *** Nine patients （five from KTGH and four from NUHS） completed this study,with five,two,and two patients of recurrence tumors （rT1）,rT2,and rT3,*** mean age was 46.4 years （range 32-63）; the mean follow-up period was 24.9 months （range 10-45）.The 2-year survival rate and the 2-year disease-free rate were 100% and 80%,respectively,in five *** significant complications or cases of mortality *** The EBE concept of EEN is suitable for early rT1 and has relatively encouraging short-term *** selected rT2,careful EBE can be performed by expanding the surgical field.A clear view of the internal carotid arteryrelated anatomy is *** the future,more series may be needed to determine the role of EEN in rNPC patients.

关键词： nasopharyngeal carcinoma nasopharyngectomy endoscopy tensor palatini muscle levator palatini muscle

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Nasopharyngeal carcinoma-Improving cure with technology and clinical trials

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 1-3页

作者： Raymond K.Tsang Division of Otolaryngology Department of SurgeryUniversity of Hong KonsHong KongChina Dept.of Surgery University of Hong Kong Queen Mary Hospital102 Pokfulam RoadHong KongChina

Nasopharyngeal carcinoma is a unique cancer in the head and neck *** has a very distinct geographic variation of incidence with more than ten times difference in incidence in high risk population compared with low-risk *** other head and neck cancer has this large worldwide variation of *** remained commonest cancer in young male adults below the age of 50 in southern China.

关键词： Nasopharyngeal carcinoma Intensity modulated radiotherapy Concurrent chemoradiotherapy Neoadjuvant chemotherapy nasopharyngectomy

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Salvage surgery for nasopharyngeal cancer

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2015年第1期1卷 -页

作者： Raymond K.Tsang William I.Wei Division of Otorhinolaryngology-Head and Neck Surgery Department of Surgery University of Hong Kong Queen Mary Hospital Hong Kong Li ShuPui ENT Head & Neck Surgery Centre Hong Kong Sanatorium & Hospital Hong Kong

Nasopharyngeal carcinoma (NPC) is a special type of head and neck cancer with a widely variable geographical variation in *** central location of the tumor inside the head coupled with the radiosensitivity of the tumor to radiation made radiation therapy the first choice in primary treatment of *** in radiotherapy and chemotherapy have markedly improved the local control of ***, a small but significant number of patients still suffered from loco-regional failures that would be amenable to *** form of retreatment was to employ a second course of *** efficacy of re-irradiation to treat local of regional recurrent NPC has been ***, the local tissue had already received a high dose of radiation and the second radiation could result in radiation toxicities to the local tissue, leading to significant *** salvage, on the other hand, could spare the patients from complications of *** to the difficult access of the nasopharynx, various surgical approaches had been devised for *** maxillary swing approach had the largest published experience with over 300 cases from various *** the recent decade, the endoscopic approach with or without robotic assistance had gained popularity for resecting small, centrally located *** minimally invasive approach further reduced the morbidity for treating locally recurrent *** recurrences had been a rare entity after the introduction of modern radiotherapy technique and concurrent *** of nodal failure with second radiation has dismal *** removal of the lymph node harboring the recurrence should be in the form of a formal radical neck *** cases of extensive nodal recurrence where microscopic disease may be present after a formal neck dissection, additional radiotherapy can be delivered with after-loading *** treatment played a defin

关键词： Nasopharyngeal carcinoma nasopharyngectomy Salvage surgery Recurrent cancer

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