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A method for assessing nanomaterial dispersion quality based on principal component analysis of particle size distribution data

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Particuology 2015年第5期13卷 30-38页

作者： R.Tantra C.Oksel K.N.Robinson A.Sikora X.Z.Wang T.A.Wilkins National Physical Laboratory Institute of Particle Science and Engineering School of Chemical and Process EngineeringUniversity of Leeds

Seemingly contradictory findings between studies are a major issue in nanoecotoxicological research and have been explained as a result of the lack of comparability between assay methods, with dispersion of nanomaterials being identified as a key factor. Here we show the use of a multivariate method, principal component analysis （PCA）, as a tool in protocol development and categorization of dispersion quality. Results show the significance of particle concentration within a protocol, and its effect on repeatability. Our results suggest that future studies should involve the use of PCA as a powerful data exploration tool to facilitate method development, comparability and integration of data across different laboratories.

关键词： Nanomaterial characterization Principal component analysis nanotoxicology Dispersion Particle size distribution

(Q)SAR modelling of nanomaterial toxicity:A critical review

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Particuology 2015年第4期13卷 1-19页

作者： Ceyda Oksel Cai Y.Ma Jing J.Liu Terry Wilkins Xue Z.Wang Institute of Particle Science and Engineering School of Chemical and Process EngineeringUniversity of Leeds School of Chemistry and Chemical Engineering South China University of Technology

There is increasing recognition that some nanomaterials may pose a risk to human health and the environment. Moreover, the industrial use of the novel engineered nanomaterials （ENMs） increases at a higher rate than data generation for hazard assessment; consequently, many of them remain untested. The large number of nanomaterials and their variants （e.g., different sizes and coatings） requiring testing and the ethical pressure towards nonanimal testing means that in a first instance, expensive animal bioassays are precluded, and the use of（quantitative） structure-activity relationships （（Q）SARs） models as an alter- native source of （screening） hazard information should be explored. （Q）SAR modelling can be applied to contribute towards filling important knowledge gaps by making best use of existing data, prioritizing the physicochemical parameters driving toxicity, and providing practical solutions for the risk assessment problems caused by the diversity of ENMs. This paper covers the core components required for successful application of （Q）SAR methods to ENM toxicity prediction, summarizes the published nano-（Q）SAR studies, and outlines the challenges ahead for nano-（Q）SAR modelling. It provides a critical review of （1） the present availability of ENM characterization/toxicity data, （2） the characterization of nanostructures that meet the requirements for （Q）SAR analysis, （3） published nano-（Q）SAR studies and their limitations, （4） in silico tools for （Q）SAR screening of nanotoxicity, and （5） prospective directions for the development of nano-（Q）SAR models.

关键词： Nanomaterial toxicity nanotoxicology QSAR NanoSAR In silico toxicity prediction

Analytical Model for Nanotoxic Assessment of a Human Respiratory System

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Journal of Wuhan University of Technology(Materials Science) 2010年第6期25卷 903-908页

作者： Neng-Chuan Tien Chun-Ping Jen Energy and Environment Research Laboratories Industrial Technology Research Institute Department of Mechanical Engineering National Chung Cheng University

A computational model for nanotoxicology was developed based on the model proposed by International Commission on Radiological ***,the fate and transport of inhaled nanoparticles in human respiratory tract were investigated by employing the compartmental *** uncertainty analysis using Latin hypercube technique was performed to address the uncertainty level of the required parameters in *** methodology could be employed in assessing the heath risks associated with general public or occupational exposure.

关键词： nanotoxicology clearance model risk assessment uncertainty

In Vivo Toxicity Assessment of Gold Nanoparticles in Drosophila melanogaster

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Nano Research 2011年第4期4卷 405-413页

作者： Pier Paolo Pompa Giuseppe Vecchio Antonio Galeone Virgilio Brunetti Stefania Sabella Gabriele Maiorano Andrea Falqui GiovanniBertoni Roberto Cingolani Italian Institute of Technology Center for Bio-Molecular Nanotechnology Via Barsanti 1-73010 Arnesano （Lecce） Italy Italian Institute of Technology Central Research Laboratories Via Morego 30-16136 Genova Italy

The growing use of nanomaterials in commercial goods and novel technologies is generating increasing questions about possible risks for human health and environment, due to the lack of an in-depth assessment of their potential toxicity. In this context, we investigated the effects of citrate-capped gold nanoparticles （AuNPs） on the model system Drosophila melanogaster upon ingestion. We observed a significant in vivo toxicity of AuNPs, which elicited clear adverse effects in treated organisms, such as a strong reduction of their life span and fertility, presence of DNA fragmentation, as well as a significant overexpression of the stress proteins. Transmission electron microscopy demonstrated the localization of the nanoparticles in tissues of Drosophila. The experimental evidence of high in vivo toxicity of a nanoscale material, which is widely considered to be safe and biocompatible in its bulk form, opens up important questions in many fields, including nanomedicine, material science, health, drug delivery and risk assessment.

关键词： Nanoparticles nanotoxicology gold in vivo studies

Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology

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Bioactive Materials 2023年第2期20卷 489-500页

作者： Hana Stepankova Hana Michalkova Zbynek Splichal Lukas Richtera Pavel Svec Tomas Vaculovic Jan Pribyl Martin Kormunda Simona Rex Vojtech Adam Zbynek Heger Department of Chemistry and Biochemistry Mendel University in BrnoZemedelska 1BrnoCZ-61300Czech Republic Central European Institute of Technology Brno University of TechnologyPurkynova 123BrnoCZ-61200Czech Republic Department of Chemistry Masaryk UniversityKamenice 5BrnoCZ-62500Czech Republic Institute of Laboratory Research on Geomaterials Faculty of Natural SciencesComenius University in BratislavaMlynska dolinaIlkovicova 684215 BratislavaSlovak Republic Central European Institute of Technology Masaryk UniversityKamenice 5BrnoCZ-62500Czech Republic Department of Physics Faculty of ScienceJ.E.Purkyne UniversityPasteurova 1Usti nad LabemCZ-40096Czech Republic

Although the general concept of nanotechnology relies on exploitation of size-dependent properties of nanoscaled materials,the relation between the size/morphology of nanoparticles with their biological activity remains not well ***,we aimed at investigating the biological activity of Se nanoparticles,one of the most promising candidates of nanomaterials for biomedicine,possessing the same crystal structure,but differing in morphology(nanorods *** particles)and aspect ratios(AR,11.5 vs.22.3 vs.1.0)in human cells and BALB/c ***,we report that in case of nanorod-shaped Se nanomaterials,AR is a critical factor describing their cytotoxicity and ***,spherical nanoparticles(AR 1.0)do not fit this statement and exhibit markedly higher cytotoxicity than lower-AR Se *** of cytotoxicity,we also show that morphology and size substantially affect the uptake and intracellular fate of Se *** line with in vitro data,in vivo *** of Se nanomaterials revealed the highest toxicity for higher-AR nanorods followed by spherical nanoparticles and lower-AR ***,we revealed that Se nanomaterials are able to alter intracellular redox homeostasis,and affect the acidic intracellular vesicles and cytoskeletal architecture in a size-and morphology-dependent *** the tested nanoparticles were produced from the similar sources,their behavior differs markedly,since each type is promising for several various application scenarios,and the presented testing protocol could serve as a concept standardizing the biological relevance of the size and morphology of the various types of nanomaterials and nanoparticles.

关键词： Aspect ratio Biocompatibility nanotoxicology Nanorods

The impact of multi-walled carbon nanotubes(MWCNTs)on macrophages:contribution of MWCNT characteristics

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Science China(Life Sciences) 2018年第11期61卷 1333-1351页

作者： Yinghe Li Jimin Cao Department of Medicine Chinese Academy of Medical Sciences Peking Union Medical CollegeBeijing 100005China Department of Physiology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical CollegeBeijing 100005China Key Laboratory of Cellular Physiology Ministry of Education Department of Physiology Shanxi Medical UniversityTaiyuan 030001China

Multi-walled carbon nanotubes(MWCNTs) have wide application prospects but also exhibit notable biotoxicity that is tightly associated with macrophages. Macrophages simultaneously act as initiators and defenders in MWCNT-induced organ lesions,and targeting macrophages with MWCNTs may be a potential immunotherapy and oncotherapy approach. This review focuses on the impacts of MWCNTs on macrophages and further discusses the influence of MWCNT characteristics on their *** on existing studies, MWCNTs stimulate macrophage migration, induce secretion of various cytokines and activate inflammatory pathways in macrophages, especially NLRP3-mediated IL-1β production. This inflammatory state, together with the oxidative stress and cell membrane lesions induced by MWCNTs, contributes to decreased phagocytic ability and cell viability, which finally results in cell apoptosis and necrosis. A series of intracellular and systemic components, such as toll-like receptor, high-mobility group box 1, Rho-associated kinases, scavenger receptor and complement components, may be involved in the above-mentioned cell-MWCNT interactions. The characteristics of MWCNTs can influence their bioactivity in macrophages both mechanically and chemically. The size(length and/or diameter), functionalization, purification and even the experimental method can affect the influence of MWCNTs on macrophages, and a better understanding of these MWCNT characteristics may benefit utilization of this nanomaterial in associated nanomedical applications.

关键词： carbon nanotube macrophage nanotoxicology nanomedicine immunity

Biomedical Effects and Nanomaterials： Nanosafety of Engineered Recent Progress

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Chinese Journal of Chemistry 2012年第9期30卷 1931-1947页

作者：王晓峰朱墨桃李敬源 CAS Key Laboratoryfor Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of ChinaBeijing 100190China

With the development of nanotechnology, there are growing concerns about biological effects and biosafety of engineered nanomaterials. On the other hand, nanoparticles are widely used in medical fields based on their novel interactions with biological entities. However, there are still a lot of challenges to establish systematic knowledge about nanotoxicology and develop biologically safer biomedical materials due to the variety of factors determining their biomedical effects and nanotoxicity. Understanding the interactions of engineered nanomaterials with the bio- logical entities becomes crucial to the further development of nanoscience and nanotechnology. In the past decade, colleagues in our laboratory intensively studied the toxic properties of various kinds of nanomaterials and their chemical mechanisms. In this paper we review the recent advance in the research on the biological effects of engi- neered nanomaterials and nanosafety issue, by focusing on the studies about representative nanomaterials in our la- boratory.

关键词： nanomaterials biomedical effect nanotoxicology surface chemistry

Toxic effects of metal oxide nanoparticles and their underlying mechanisms

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Science China Materials 2017年第2期60卷 93-108页

作者：王艳丽丁琳姚晨婕李晨晨邢晓军黄雅男顾天骄吴明红 Institute of Nano-chemistry and Nano-biology Shanghai University Shanghai 200444 China Harvard School of Public Health Harvard University Boston Massachusetts 02115 USA

Nanomaterials have attracted considerable interest owing to their unique physicochemical *** wide application of nanomaterials has raised many concerns about their potential risks to human health and the *** oxide nanopartides（MONPs）,one of the main members of nanomaterials,have been applied in various fields,such as food,medicine,cosmetics,and *** review highlights the bio-toxic effects of widely applied MONPs and their underlying *** main underlying toxicity mechanisms,reactive oxygen species（ROS）-and non-ROS-mediated toxidties,of MONPs have been widely *** activates oxidative stress,which leads to lipid peroxidation and cell membrane *** addition,ROS can trigger the apoptotic pathway by activating caspase-9 ***-ROS-mediated toxicity mechanism includes the effect of released ions,excessive accumulation of NPs on the cell surface,and combination of NPs with specific death ***,the combined toxicity evaluation of some MONPs is also *** may dramatically change when nanomaterials are used in a combined system because the characteristics of NPs that play a key role in their toxicity such as size,surface properties,and chemical nature in the complex system are different from the pristine NPs.

关键词： metal oxide nanoparticles bio-toxicity effect nanotoxicology underlying mechanism

Nanomaterials and Cell Interactions: A Review

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Journal of Biomaterials and Nanobiotechnology 2017年第4期8卷 220-228页

作者： Tenderwealth Clement Jackson Bernard Opatimidi Patani Mary Blessed Israel Department of Pharmaceutics and Pharmaceutical Technology University of Uyo Uyo Nigeria Medical Department Nigerian AGIP Oil Company Port Harcourt Nigeria Department of Biochemistry University of Uyo Uyo Nigeria

nanotoxicology, a branch of bionanoscience focuses on the study of the hazardous interactions between nanomaterials and the ecosystem and ascertaining its consequent implications. Nanomaterial-cell interactions are dependent on numerous factors such as size, shape, type and surface coatings/charge of nanomaterials. These factors in association with cell membrane factors such as charge and formation of the protein corona influence the uptake and internalization of these particles leading to their potential toxicity. Understanding the different routes of exposure, their transport, behaviour and eventual fate is also of importance. Toxicities that occur to the living systems are consequences of various causes/dysfunctions such as ROS production, loss of membrane integrity, releases of toxic metal ions that bind with specific cell receptors and undergo certain conformations that inhibit normal cell function resulting in cytotoxicity, genotoxicity and possible cell necrosis. This paper attempts to review the available research pertaining to nanomaterial-cell interactions and their potential toxicity.

关键词： nanotoxicology Nanomaterials Cell Cytotoxicity Oxidative Stress Genotoxicity