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Can the venerated silk be the next generation nanobiomaterialfor biomedical device designing, regenerative medicine and drugdelivery? Prospects and hitches

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Bio-Design and Manufacturing 2019年第4期2卷 278-286页

作者： Rocktotpal Konwarh Department of Biotechnology Addis Ababa Science and Technology University16417 Akaki KalityAddis AbabaEthiopia Centre of Excellence NanotechnologyAddis Ababa Science and Technology University16417 Akaki KalityAddis AbabaEthiopia

Of late, the relevance of silk in a myriad of material science and biotechnological realms has been realized, as attested by the incessantly clambering number of reports and patents in the scienti fic repositories. The write-up is geared off with a scrutiny into the pertinence of the basic nano-structural features of silk, christened as the ‘queen of textile’ for exemplary bioengi- neering applications including designing and fabrication of devices for micro fluidics, opto fluidics, chemo/bio sensing, etc. Then, the major thrust of this short review is directed towards comprehending the prospects of using silk-based biomaterials (e.g. sca ffolds, electrospun membranes, films, hydrogels, bioinks) for tissue engineering and regenerative medicine as well as targeted delivery of various biomolecular cargoes/therapeutic agents, etc., as vouched by few avant-garde endeavours of the recent years. The write-up is entwined with a discussion on the various factors that could plausibly hinder the realization of silk as the next-generation nanobiomaterial, suggestions for some approaches to dodge and deal with the practical snags and what lies ahead!

关键词： Drug delivery Microfluidics nanobiomaterial Regenerative medicine Silk Tissue engineering

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Nanocomposites and bone regeneration

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Frontiers of Materials Science 2011年第4期5卷 342-357页

作者： Roshan JAMES Meng DENG Cato T. LAURENCIN Sangamesh G. KUMBAR Institute for Regenerative Engineering University of Connecticut Health Center Farmington CT 06030 USA New England Musculoskeletal Institute University of Connecticut Health Center Farmington CT 06030 USA Department of Orthopaedic Surgery University of Connecticut Health Center Farmington CT 06030 USA Department of Chemical Materials and Biomolecular Engineering University of Connecticut Storrs CT 06269 USA

This manuscript focuses on bone repair/regeneration using tissue engineering strategies, and highlights nanobiotechnology developments leading to novel nanocomposite systems. About 6.5 million fractures occur annually in USA, and about 550,000 of these individual cases required the application of a bone graft. Autogenous and allogenous bone have been most widely used for bone graft based therapies; however, there are significant problems such as donor shortage and risk of infection. Alternatives using synthetic and natural biomaterials have been developed, and some are commercially available for clinical applications requiring bone grafts. However, it remains a great challenge to design an ideal synthetic graft that very closely mimics the bone tissue structurally, and can modulate the desired function in osteoblast and progenitor cell populations. nanobiomaterials, specifically nanocomposites composed of hydroxyapatite （HA） and/or collagen are extremely promising graft substitutes. The biocomposites can be fabricated to mimic the material composition of native bone tissue, and additionally, when using nano-HA （reduced grain size）, one mimics the structural arrangement of native bone. A good understanding of bone biology and structure is critical to development of bone mimicking graft substitutes. HA and collagen exhibit excellent osteoconductive properties which can further modulate the regenerative/ healing process following fracture injury. Combining with other polymeric biomaterials will reinforce the mechanical properties thus making the novel nano-HA based composites comparable to human bone. We report on recent studies using nanocomposites that have been fabricated as particles and nanofibers for regeneration of segmental bone defects. The research in nanocomposites, highlight a pivotal role in the future development of an ideal orthopaedic implant device, however further significant advancements are necessary to achieve clinical use.

关键词： bone graft substitute nanocomposite hydroxyapatite collagen nanofiber,biomimetic nanobiomaterial osteogenic segmental defect tibia defect

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Osteogenic and antibacterial dual functions of a novel levofloxacin loaded mesoporous silica microspheres/nano-hydroxyapatite/ polyurethane composite scaffold

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Genes & Diseases 2021年第2期8卷 193-202页

作者： Zhiping Kuang Guangming Dai Ruijie Wan Dongli Zhang Chen Zhao Cheng Chen Jidong Li Hongchen Gu Wei Huang Department of Orthopedic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016PR China Department of Orthopaedic Surgery Chongqing Traditional Chinese Medicine HospitalChongqing400011PR China Research Center for Nano-Biomaterials Analytical&Testing CenterSichuan UniversityChengduSichuan Province610065PR China State Key Laboratory of Oncogenes and Related Genes School of Biomedical EngineeringMed-X Research InstituteShanghai Jiaotong UniversityShanghai200240PR China

Lev/MSNs/n-HA/PU has been proved to be a novel scaffold material to treat bone defect caused by chronic *** have previously identified that this material can effectively treat chronic osteomyelitis caused by Staphylococcus aureus in ***,the potential mechanisms of antibacterial and osteogenic induction properties remain ***,for osteogenesis property,immunohistochemistry,PCR,and Western blot were performed to detect the expression of osteogenic ***,flow cytometry and TUNEL were applied to analyze MC3T3-E1 proliferation and *** antibacterial property,the material was co-cultivated with bacteria,bacterial colony forming units was counted and the release time of the effective levofloxacin was assayed by agar disc-diffusion ***,scanning electron microscope was applied to observe adhesion of *** terms of osteogenic induction,we found BMSCs adherently grew more prominently on Lev/MSNs/n-HA/***/MSNs/n-HA/PU also enhanced the expression of osteogenic markers including OCN and COL1a1,as well as effectively promoted the transition from G1 phase to G2 ***,Lev/MSNs/n-HA/PU could reduce apoptosis of ***,both Lev/MSNs/n-HA/PU and n-HA/PU materials could inhibit bacterial colonies,while Lev/MSNs/n-HA/PU possessed a stronger antibacterial activities,and lower bacterial adhesion than n-HA/*** results illustrated that Lev/MSNs/n-HA/PU composite scaffold possess favorable compatibility in vitro,which induce osteogenic differentiation of MSCs,promote proliferation and differentiation of MC3T3-E1,and inhibit ***,clear in vitro antibacterial effect of Lev/MSNs/n-HA/PU was also *** summary,this study replenishes the potential of Lev/MSNs/n-HA/PU composite scaffold possess dual functions of anti-infection and enhanced osteogenesis for future clinical application.

关键词： Antibacterial Composite scaffold Levofloxacin nanobiomaterial Osteogenesis

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Molecular Modeling of Cell Adhesion Peptides on Hydroxyapatite and TiO<sub>2</sub>Surfaces: Implication in Biomedical Implant Devices

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Journal of Biomaterials and Nanobiotechnology 2013年第4期4卷 351-356页

作者： Subhashis Biswas Udo Becker Department of Chemistry Narula Institute of Technology Westbengal University of Technology Kolkata India Department of Earth and Environmental Sciences University of Michigan Ann Arbor USA.

Molecular modeling as a tool in studying peptide-substrate interactions provides insight on peptide adsorption conformation, adsorption energy, and stability of the peptide-inorganic interface. This work investigates the hydration and interaction of cell-adhesion peptides, specifically RGD and YIGSR, with the hydroxyapatite surface and TiO2 surface in cluster and periodic boundary condition approaches. The comparison of adsorption energies of RGD and YIGSR on both Hydroxyapatite (HA) and TiO2 surfaces reveals the similarities in adsorption energy and orientation pattern of peptides on both surfaces. The models demonstrate that initial peptide orientation affects adsorption energy for both. YIGSR is consistently more strongly adsorbed to HA-(001) surfaces and steps than RGD for both the surfaces. In addition, RGD maintained its “hairpin”-like structure during adsorption on a flat HA-(001) surface, and a slightly “relaxed hairpin” structure on TiO2 (110) surface. Adsorption energies of RGD on TiO2 (110) surface are significantly more favorable compared to HA-(001) surface, suggesting potential role of TiO2 as biomedical implants when tissue regeneration occurs via cell signaling.

关键词： Hydroxyapatite nanobiomaterial Bone-Tissue Engineering RGD TiO2

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Nanostructured Biomaterials and Biomimicking in Biomaterials Development for the Human Body Tissue Repair

Nanostructured Biomaterials and Biomimicking in Biomaterials...

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中国化学会第26届学术年会纳米化学分会场

作者： Min Wang * Dept. of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong

Nanostructured biomaterials and objects of nanometer dimensions have unique properties that conventional biomaterials of micrometer-level structures or devices of above-the-micrometer dimensions do not possess. Nanotechnologies currently available have already made profound influences on our strategies for the human body tissue repair. They enable us to produce nanofibers, nanoparticles and nanocomposites that are potentially very useful for biomedical applications. Our work on micro- and nano-sized fibers has focused on using the electrospinning technique to fabricate biodegradable fibers. Electrospun nanofibrous structures mimic the natural extracellular matrix of human body tissues. By judicious selection of electrospinning parameters, nonwoven micro- or nano-fibrous polyhydroxybutyrate （PHB） or other polymer membranes can be fabricated. It is also possible to produce micro-sized composite fibers of biodegradable polymer matrices containing nano-sized hydroxyapatite （HA） particles. These nanocomposite fibers can be used for bone tissue engineering as HA incorporated imparts osteoconductivity on the fibrous porous structure. It has become possible to fabricate fibrous scaffolds containing aligned polymer fibers. Fibrous membranes having multilayered structures with each individual layer being aligned fibers can also be made. These porous structures of aligned fibers have potentials of being used in tendon/ligament, skin, blood vessel, and neural tissue engineering. Our exploration into the synthesis of nano-sized bioactive calcium phosphate （Ca-P） particles has several objectives. One of them is to use the Ca-P nanoparticles in biodegradable composites or scaffolds for bone tissue repair. A nanoemulsion process has been developed for the synthesis of these particles whose diameters were 5-30nm and whose Ca:P ratio could be varied. Composite scaffolds were then made using the selective laser sintering technology. In vitro studies showed that osteoblastic cells atta

关键词： nanoparticle nanofiber nanocomposite nanobiomaterial biomimetic

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