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Electrophoretic-deposited novel ternary silk fibroin/graphene oxide/hydroxyapatite nanocomposite coatings on titanium substrate for orthopedic applications

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Frontiers of Materials Science 2016年第3期10卷 270-280页

作者： Ming LI Pan XIONG Maosong MO Yan CHENG Yufeng ZHENG Institute of Electrical Engineering Chinese Academy of Sciences Beijing 100190 China School of Electronic Electrical and Communication Engineering University of Chinese Academy of Sciences Beijing 100049 China Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China

The combination of graphene oxide （GO） with robust mechanical property, silk fibroin （SF） with fascinating biological effects and hydroxyapatite （HA） with superior osteogenic activity is a competitive approach to make novel coatings for orthopedic applications. Herein, the feasibility of depositing ternary SF/GO/HA nanocomposite coatings on Ti substrate was firstly verified by exploiting electrophoretic nanotechnology, with SF being used as both a charging additive and a dispersion agent. The surface morphology, microstructure and composition, in vitro hemocompatibility and in vitro cytocompatibility of the resulting coatings were investigated by SEM, Raman, FTIR spectra and biocompatibiUty tests. Results demonstrated that GO, HA and SF could be co-deposited with a uniform, smooth thin-film morphology. The hemolysis rate analysis and the platelet adhesion test indicated good blood compatibility of the coatings. The human osteosarcoma MG63 cells displayed well adhesion and proliferation behaviors on the prepared coatings, with enhanced ALP activities. The present study suggested that SFIGO/HA nanocomposite coatings could be a promising candidate for the surface functionalization of biomaterials, especially as orthopedic implant coating.

关键词： graphene oxide silk fibroin hydroxyapatite nano-biocomposite coatings electrodeposition

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