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Synergistic anti-inflammatory and osteogenic n-ha/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

引用

Bioactive Materials 2021年第5期6卷 1255-1266页

作者： Limei Li Mali Yu Yao Li Qing Li Hongcai Yang Meng Zheng Yi han Di Lu Sheng Lu Li Gui Yunnan Key Laboratory of Stem Cell and Regenerative Medicine Science and Technology Achievement Incubation CenterKunming Medical UniversityKunming650500China Department of Stomatology The First People’s Hospital of Yunnan ProvinceKunming650032China Department of neurology The First Affiliated HospitalKunming Medical UniversityKunming650000China Yunnan Key Laboratory of Digital Orthopaedics Department of OrthopaedicsThe First People’s Hospital of Yunnan ProvinceKunming650032China Department of Endocrinology The Third People’s Hospital of Yunnan ProvinceKunming650011China

The development of functional materials for osteoporosis is ultimately required for bone ***,grafts were accompanied by increasing pro-inflammatory cytokines that impaired bone *** this work,nano-hydroxyapatite(n-ha)/resveratrol(res)/chitosan(cs)composite microspheres were designed to create a beneficial microenvironment and help improve the osteogenesis by local sustained release of *** of in vitro release confirmed the feasibility of n-ha/res/cs microspheres for controlled res ***,microspheres had anti-inflammatory activity evidenced by the decreased expression of pro-inflammatory cytokines TnF-α,IL-1βand inOS in RAW264.7 cells in a dose dependent ***,enhanced adhesion and proliferation of BMScs seeded onto microspheres demonstrated that composite microspheres were conducive to cell *** ability to enhance osteo-differentiation was supported by up-regulation of Runx2,ALP,Col-1 and OCn,and substantial mineralization in osteogenic *** implanted into bone defects in the osteoporotic rat femoral condyles,enhanced entochondrostosis and bone regeneration suggested that the n-ha/res/cs composite microspheres were more favorable for impaired fracture *** results indicated that optimized n-ha/res/cs composite microspheres could serve as promising multifunctional fillers for osteoporotic bone defect/fracture treatment.

关键词： n-ha/res/cs microsphere Anti-inflammation Osteo-differentiation Osteoporotic bone regeneration

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