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A study on vestibular-evoked myogenic potentials via galvanic vestibular stimulation in normal people

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Journal of Otology 2018年第1期13卷 16-19页

作者： Ying Cheng Yusuke Kimura Kimitaka Kaga National Institute of Sensory Organs Tokyo Medical Center Japan The Department of Otolaryngology Head and Neck Surgery in the Second Affiliated Hospital of Xi 'an Jiaotong University Shaanxi Province PR China

Objectives: The aim of our study is to examine vestibular-evoked myogenic potentials(VEMPs) elicited by the galvanic vestibular stimulation in the sternocleidomastoid muscle(SCM) in healthy subjects for clinical applications of auditory neuropathy or vestibular neuropathy in the future.Methods: We enrolled sixteen healthy subjects to record the average responses of SCM to galvanic vestibular stimulation(GVS) [current 3 mA;duration 1 ms] by electromyography(EMG). SPSS 18.0 software was used to analyze the obtained data for mean and standard deviation.Results: In all healthy subjects mastoid-forehead galvanic vestibular stimulation produced a positive-negative biphasic EMG responses on SCM ipsilateral to the cathodal electrode. The latency of p13 was 11.7 ± 3.0 ms. The latency of n23 was 17.8 ± 3.4 ms. The amplitude of p13-n23 was147.0 ± 69.0 μV. The interaural asymmetry ratio(AR) of p13, n23 latency and the amplitude was respectively 0.12 ± 0.09, 0.08 ± 0.08 and0.16 ± 0.10.Discussions: Galvanic vestibular stimulation could elicit biphasic EMG responses from SCM via the vestibular nerve but not from the otolith organs. Galvanic stimulation together with air conducted sound(ACS) or bone conducted vibration(BCV) can elicit VEMPs and may enable the differentiation of retrolabyrinthine lesions from labyrinthine lesions in vestibular system.

关键词： Galvanic vestibular stimulation Vestibular nerve Vestibular-evoked myogenic potentials Sternocleidomastoid muscle Interaural asymmetry ratio (AR)

Functional expression of gap junction gene Cx43 and the myogenic differentiation of rhabdomyosarcoma cells

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Science China Chemistry 1995年第3期38卷 305-312页

作者：林仲翔张志谦韩亚玲 C.C.G.Naus K.R.Yu H.Holtzer Department of Cell Biology Beijing Medical School of Oncology Beijing Institute for Cancer ResearchBeijing 100034 China Department of Anatomy University of Western Ontorio London ON N6A5C1Canada Department of Cell and Developmental Biology University of Pennsylvania PA19104 USA

Rhabdomyosarcoma (RD) cells express low levels of the gap junction protein connexin 43 (Cx43), and its mRNA, and display very weak gap junctional intercellular communication (GJIC) as detected by Cx43 immunofluorescence, slot-blot and dye-transfer methods. These cells grow rapidly and show aberrant and incomplete myogenic differentiation. To investigate the role of gap junctions in these cells, the expression of Cx43 with relation to cell growth and myogenic differentiation in RD single-cell subclones-RDL3 and RDL6 is studied. The subclone RDL3 grows slowly and displays better myogenic differentiation. The expression of Cx43, its mRNA and the GJIC in RDL3 is comparable to that in normal myoblasts. Another subclone RDL6 which grows rapidly, but is poorly differentiated, expresses very low levels of Cx43 and its mRNA, and very weak GJIC. By using the calcium phosphate precipitate transfection technique, a full-length cDNA-encoding Cx43 and a pSV2neo have been introduced into the RDL6 cells. Several

关键词： connexin 43 gap junctional intercellular communication rhabdomyosarcoma myogenic differentiation single-cell clone cell transfection.

Assessment of myogenic Power Expenditure Due to Arterial Wall Smooth Muscle Contraction Based upon the Fractal Nature of Vascular Trees

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Applied Mathematics 2014年第12期5卷 1750-1762页

作者： Akira Kamiya Masahiro Shibata Kimiko Yamamoto Research Laboratory for Interdisciplinary Sciences Tokyo Japan

The purpose of this study is 1) to present a biomechanical model for evaluating the myogenic power expended in an arterial segment due to vascular smooth muscle contraction (VSMC) and 2) to assess the total power expenditure in the entire systemic arterial tree by utilizing the fractal nature of the branching architecture. The model is based on the mechanical equilibrium between the stretch stress exerted by blood pressure inside the vessel lumen and constricting stress elicited by VSMC in the vascular wall. An expression for myogenic power expenditure is formulated for a unit wall mass as a function of the internal vessel radius and extent of strain. This expression was then integrated over selected range of vessel radii, by taking into account of the fractal nature of the branching structure. When the total myogenic power expended in the systemic arterial tree in rat at the moderate strain level is converted to the oxygen consumption rate, it amounts to approximately 18% of the whole body oxygen consumption rate. This suggests that the mechanical power expenditure due to VSMC is a significant factor that should not be ignored in studies of vascular energetics.

关键词： myogenic Active Stress Biomechanics Fractal Integral Oxygen Consumption Allometric Law

Denervated muscle extract promotes recovery of muscle atrophy through activation of satellite cells. An experimental study

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Journal of Sport and Health Science 2019年第1期8卷 23-31页

作者： Eduardo Aguera Salvador Castilla Evelio Luque Ignacio Jimena Ignacio Ruz-Caracuel Fernando Leiva-Cepas Jos Pea Department of Neurology Maimonides Institute for Biomedical Research IMIBIC Reina Sofia University Hospital University of Cordoba Department of Critical Care and Emergency Reina Sofia University Hospital University of Cordoba Department of Morphological Sciences Section of Histology Faculty of Medicine and Nursing Maimonides Institute for Biomedical Research IMIBICReina Sofia University Hospital University of Cordoba

Purpose: The objective of the present study was to determine whether a denervated muscle extract(DmEx) could stimulate satellite cell response in denervated muscle.Methods: Wistar rats were divided into 4 groups: normal rats, normal rats treated with DmEx, denervated rats, and denervated rats treated with DmEx. The soleus muscles were examined using immunohistochemical techniques for proliferating cell nuclear antigen, desmin, and myogenic differentiation antigen(MyoD), and electron microscopy was used for analysis of the satellite cells.Results: The results indicate that while denervation causes activation of satellite cells, DmEx also induces myogenic differentiation of cells localized in the interstitial space and the formation of new muscle fibers. Although DmEx had a similar effect in nature on innervated and denervated muscles, this response was of greater magnitude in denervated vs. intact muscles.Conclusion: Our study shows that treatment of denervated rats with DmEx potentiates the myogenic response in atrophic denervated muscles.

关键词： Muscle atrophy Muscle denervation Muscle extract myogenic response Satellite cell Skeletal muscle

Clinicopathological features of pseudomyogenic hemangioendothelioma and precision therapy based on whole exome sequencing

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Cancer Communications 2020年第4期40卷 197-201页

作者： Junqiang Wei Zhichao Liao Gang Zhao Nazmun Nahar Chao Zhang Jia Lu Yun Yang Jilong Yang Department of Bone and Soft Tissue Tumors Tianjin Medical University Cancer Institute and HospitalTianjin 300060P.R.China National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300060P.R.China Department of Pathology Tianjin Medical University Cancer Institute and HospitalTianjin 300060P.R.China Department of Orthopedics Affiliated Hospital of Chengde Medical CollegeChengdeHebei 067000P.R.China International Medical School Tianjin Medical UniversityTianjin 300061P.R.China

Dear Editor Pseudomyogenic hemangioendothelioma(PHE)is a newly recognized subtype of hemangioendothelioma characterized by the presence of fibrohistiocytic and myoid cells arranged in a fibroma-like or dermatofibroma-like pattern[1].This rare type of tumor was first named by Hornick and Fletcher[2]and categorized as the novel soft tissue tumor classification system of the World Health Organization in 2013[3].Prior to this,it was referred to as fibroma-like variant of epithelioid sarcoma(ES)and epithelioid sarcoma-like hemangioendothelioma[4].

关键词： sarcoma myogenic endo

Features of Otolithic Dysfunction in Patients with Sudden Sensorineural Hearing Loss at Different Ages

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Journal of Biosciences and Medicines 2015年第10期3卷 1-8页

作者： Xiaorong Niu Qing Zhang Xinda Xu Peng Han Ying Cheng Ying Gao Rui Zhang Yintong Yang Zichen Chen Juan Hu Yanfei Chen Min Xu Department of Otorhinolaryngology Head and Neck Surgery Ear Institute Second Affiliated Hospital Xi’an Jiaotong University College of Medicine Xi’an China EYE and ENT Hospital of Fudan University Shanghai China Department of Otolaryngology Xi’an Children’s Hospital Xi’an China Department of Otolaryngology Xi’an Fourth People’s Hospital Xi’an China

Objective: To observe the otolithic function in sudden sensorineural hearing loss (SSHL) patients in different age groups by using vestibular evoked myogenic potentials (VEMPs). Methods: One hundred and seventy unilateral SSHL patients were divided into 5 age groups. The 170 affected ears belonged to study group. The opposite healthy ears of 170 patients and 138 normal ears of 69 age and sex-matched normal people at different ages were set as control groups. Ocular VEMP (oVEMP) and cervical VEMP (cVEMP) both evoked by air-conducted sound (ACS) were employed for vestibular otolithic function assessment. Results: The response rates of cVEMP and oVEMP were lower and abnormal rates were higher in affected ears of SSHL patients compared to the opposite healthy ears and normal control ears in all age groups, except patients over 60 years. The response rates of VEMPs significantly declined with increasing age, not only in normal control ears, but also in affected and healthy ears of SSHL patients. But, the abnormal rates of VEMPs showed no significant difference in affected ears at different ages. Conclusions: Dysfunction of vestibular otolithic organs in SSHL patients presented respective features at different ages. It is necessary to consider the age when the clinicians determine the otolithic condition of patients based on the VEMPs.

关键词： Ocular Vestibular Evoked myogenic Potential (oVEMP) Cervical Vestibular Evoked myogenic Potential (cVEMP) SSHL Age Otolithic Function

Role of endothelium on the abnormal Angiotensin-mediated vascular functions in epileptic rats

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Journal of Biophysical Chemistry 2012年第2期3卷 174-182页

作者： Carolina Restini Rosana Reis Claudio Costa-Neto Norberto Garcia-Cairasco José Cortes-de-Oliveira Lusiane Bendhack Universidade de Ribeiraão Preto—UNAERP. Curso de Medicina Ribeirāo Preto Brasil Faculdade de Ciências Farmacêuticas de Ribeiro Preto-USP Ribeiro Preto Brasil Faculdade de Medicina de Ribeirão Preto-USP Ribeir&atildeo Preto Brasil Faculdade de Medicina de Ribeiro Preto-USP Ribeiro Preto Brasil

Epidemiological studies have found that the risk for cardiovascular disease is increased in patients with epilepsy. The Renin Angiontensin System (RAS), an important player in vascular tone control, is also involved in many neurological disorders, including seizures and epilepsy. Although it has been reported that Angiotensin II (Ang II) release and Angiotensin receptors expression are altered in many cerebral areas in patients/animal models with neurological disorders, there are no data on the vascular function. We evaluated Ang I and Ang II-mediated vascular responses and to correlate their contractile responses to the pres- ence of endothelium and the protein levels of components of the RAS (AT1, AT2, Mas and ACE) in aorta isolated from genetically epileptic rats (WAR strain). The major finding was that the vascular contractile response induced by Ang I and Ang II is endothelium-dependent. Ang II induced contractions in aortas from Wistar rats either with intact endothelium (E+) (1.16 ± 0.04 g, n = 6) and endothelium-denuded (E-) (1.24 ± 0.04 g, n = 6). Maximum contractile response (ME) induced by Ang I was lower in Wistar E+ (0.45 ± 0.03 g, n = 6) compared with Wistar E- (1.13 ± 0.08 g, n = 6). Ang I and Ang II failed to induce contraction in WAR E+, whereas the ME induced by Ang I in WAR E- was lower (0.52 ± 0.04 g, n = 11) than in the Wistar. ME induced by Ang II in aortas from WAR was also lower (0.40 ± 0.03 g, n = 11) compared with Wistar. AT1 receptor expression in both E+ WAR and Wistar was lower than in both E- WAR and Wistar. AT2 and Mas receptor expression was higher in Wistar E- and E+ as compared to WAR E- and E+. ACE expression was higher in both E+ WAR and Wistar, but it was lower in both E- WAR and Wistar. Endothelium impairs the contractile response induced by Angiotensin in WAR, suggesting that endothelial relaxing factors play important role on the aorta contraction.

关键词： Endothelium Aorta myogenic Tone Angiotensin Angiotensin II Receptor Epilepsy

正常志愿者前庭诱发肌源性电位测试正常值及其临床意义

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中国耳鼻咽喉头颈外科 2016年第3期23卷 175-176页

作者：戴巧妹贺军娜刘晓培赵彩芸李爱英宋建伟北京首大耳鼻喉医院耳鼻咽喉科北京100078

前庭诱发肌源性电位（vestibular evoked myogenic potential,VEMP）是指用高强度声波刺激一侧球囊时在紧张的胸锁乳突肌上记录到的肌源性电位。VEMP反映人前庭-颈反射通路的功能,是一种客观无创的电生理检查方法。

关键词：前庭神经(Vestibular Nerve) 球囊和椭圆囊(Saccule and Utricle) 声刺激(Acoustic Stimulation) 前庭诱发肌源性电位(vestibular evoked myogenic potential)