Denervated muscle extract promotes recovery of muscle atrophy through activation of satellite cells. An experimental study

作     者：Eduardo Aguera Salvador Castilla Evelio Luque Ignacio Jimena Ignacio Ruz-Caracuel Fernando Leiva-Cepas Jos Pea 

作者机构：Department of NeurologyMaimonides Institute for Biomedical Research IMIBIC Reina Sofia University Hospital University of Cordoba Department of Critical Care and Emergency Reina Sofia University Hospital University of Cordoba Department of Morphological Sciences Section of Histology Faculty of Medicine and Nursing Maimonides Institute for Biomedical Research IMIBICReina Sofia University Hospital University of Cordoba 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2019年第8卷第1期

页      面：23-31页

核心收录：

学科分类：0403[教育学-体育学] 04[教育学] 

主　　题：Muscle atrophy Muscle denervation Muscle extract Myogenic response Satellite cell Skeletal muscle 

摘      要：Purpose: The objective of the present study was to determine whether a denervated muscle extract(DmEx) could stimulate satellite cell response in denervated ***: Wistar rats were divided into 4 groups: normal rats, normal rats treated with DmEx, denervated rats, and denervated rats treated with DmEx. The soleus muscles were examined using immunohistochemical techniques for proliferating cell nuclear antigen, desmin, and myogenic differentiation antigen(MyoD), and electron microscopy was used for analysis of the satellite ***: The results indicate that while denervation causes activation of satellite cells, DmEx also induces myogenic differentiation of cells localized in the interstitial space and the formation of new muscle fibers. Although DmEx had a similar effect in nature on innervated and denervated muscles, this response was of greater magnitude in denervated vs. intact ***: Our study shows that treatment of denervated rats with DmEx potentiates the myogenic response in atrophic denervated muscles.