检索结果-南通市图书馆

Efficacy of electroacupuncture on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass:a systematic review and Meta-analysis

引用

Journal of Traditional Chinese Medicine 2024年第1期44卷 1-15页

作者： QIN Xiaoyu WANG Chunai XUE Jianjun ZHANG Jie LU Xiaoting DING Shengshuang GE Long WANG Minzhen the First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730030China Department of Anesthesiology Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050China Evidence-based Medicine Center Lanzhou UniversityLanzhou 730030China Institute of Epidemiology and Statistics School of Public HealthLanzhou UniversityLanzhou 730030China

OBJECTIVE:To evaluate the efficacy of electroacupuncture(EA)intervention on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass(CPB).METHODS:Eight databases,including Pub Med,Embase,the Cochrane Library,Web of Science,Chinese Bio Medical Literature Database,China National Knowledge Infrastructure Database,Wanfang Data,China Science and Technology Journal Database,and two clinical trial registries,were *** randomized controlled trials(RCTs)related to EA intervention in cardiac surgery with CPB were *** on the inclusion and exclusion criteria,two researchers independently screened articles and extracted *** the quality evaluation,RevMan 5.3 software was used for ***:Fourteen RCTs involving 836 patients were *** with the control treatment,EA significantly increased the incidence of cardiac automatic rebeat after aortic unclamping[relative risk(RR)=1.15,95%confidence interval(CI)(1.01,1.31),P<0.05;moderate].Twenty-four hours after aortic unclamping,EA significantly increased the superoxide dismutase[standardized mean difference(SMD)=0.96,95%CI(0.32,1.61),P<0.05;low],and interleukin(IL)-2[SMD=1.33,95%CI(0.19,2.47),P<0.05;very low]expression levels and decreased the malondialdehyde[SMD=-1.62,95%CI(-2.15,-1.09),P<0.05;moderate],tumour necrosis factor-α[SMD=-1.28,95%CI(-2.37,-0.19),P<0.05;moderate],and cardiac troponin I[SMD=-1.09,95%CI(-1.85,-0.32),P<0.05;low]expression levels as well as the inotrope scores[SMD=-0.77,95%CI(-1.22,-0.31),P<0.05;high].There was no difference in IL-6 and IL-10 expression *** amount of intraoperative sedative[SMD=-0.31,95%CI(-0.54,-0.09),P<0.05;moderate]and opioid analgesic[SMD=-0.96,95%CI(-1.53,-0.38),P<0.05;low]medication was significantly lower in the EA group than in the control ***,the postoperative tracheal intubation time[SMD=-0.92,95%CI(-1.40,-0.45),P<0.05;low]and intensive care unit stay[SMD=-1.

关键词： electroacupuncture cardiopulmonary bypass thoracic surgery myocardial ischaemia-reperfusion injury myocardial protection postoperative rehabilitation Meta-analysis randomized controlled trial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Network pharmacology and subsequent experimental validation reveal the synergistic myocardial protection mechanism of Salvia miltiorrhiza *** Carthamus tinctorius L.

引用

Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 44-54页

作者： Linying Zhong Ling Dong Jing Sun Jie Yang Zhiying Yu Ping He Bo Zhu Yuxin Zhu Siyuan Li Wenjuan Xu School of Life Sciences Bejing University of Chinese MedicineBeijing 102488China School of Chinese Materia Medica Beijing University of Chinese MedicineBejing 102488China

Objective:To reveal the molecular mechanism underlying the compatibility of Salvia miltiorrhiza Bge(***,Dan Shen)and *** L.(***,Hong Hua)as an herb pair through network pharmacology and subsequent experimental ***:Network pharmacology was applied to construct an active ingredient-efficacy target-disease protein network to reveal the unique regulation pattern of *** and *** as herb *** docking was used to verify the binding of the components of these herbs and their potential *** H9c2 glucose hypoxia model was used to evaluate the efficacy of the components and their synergistic effects,which were evaluated using the combination *** blot was performed to detect the protein expression of these ***:Network pharmacology analysis revealed 5 pathways and 8 core targets of *** and *** in myocardial *** of the core targets were enriched in the hypoxia-inducible factor-1(HIF-1)signaling *** achieved vascular tone mainly by regulating the target genes of the HIF-1 *** an upstream gene of the HIF-1 pathway,STAT3 can be activated by the active ingredients cryptotanshinone(Ctan),salvianolic acid B(Sal.B),and myricetin(Myric).Cell experiments revealed that Myric,Sal.B,and Ctan also exhibited synergistic myocardial protective *** docking verified the strong binding of Myric,Sal.B,and Ctan to *** blot further showed that the active ingredients synergistically upregulated the protein expressionof ***:The pharmacodynamic transmission analysis revealed that the active ingredients of *** and *** can synergistically resist ischemia through various targets and *** study provides a methodological reference for interpreting traditional Chinese medicine compatibility.

关键词： S.miltiorrhiza-C.tinctorius herb pair Compatibilitymechanism Networkpharmacology Multipletargeteffect myocardial protection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

myocardial protection during heart surgery in China

引用

Chinese Medical Journal 2007年第1期120卷 62-67页

作者： Bingyang Ji Jinping Liu myocardial protection cardiopulmonary bypass cardiac surgeryDepartment of Pediatric Cardiology Hershey Medical Center PennState College of Medicine USA Department of Cardiopulmonary Bypass Cardiovascular InstituteFuwai Hospital Peking Union Medical College ＆ ChineseAcademy of Medical Sciences Beijing 100730 China

myocardial protection （MP） is the key for cardiopulmonary bypass （CPB） heart surgery. MP during cardiac surgery （CS） aims to preserve myocardial function while providing a bloodless and motionless operating field. Strategies on how to attenuate or prevent post-ischemic myocardial dysfunction that occurs intra-operatively during CS have been discussed for more than half a century. In 1950, Bigelow et al, first reported to decrease myocardial oxygen demand by means of hypothermia. Moreover, Melrose and coworkers2 described the use of electromechanical cardiac arrest induced by potassium infusion, permitting CS to be performed on a non-beating flaccid heart and clear surgical field. The combination of both of these techniques has been the golden standard in MP during surgery until now, allowing surgery with excellent clinical outcome. In 1975, Braimbridge et al introduced a crystalloid solution into clinical practice at St. Thomas Hospital. By the 1980s, blood-based potassium solutions were advocated to further improve MP and to reduce myocardial enzymes release based on the theory that blood would be a superior delivery vehicle for its oxygenating and buffering ***, the majority of MP strategies now available do allow patients to undergo conventional and complex CS with an operative mortality rate ranging from less than 2% to 4%.

关键词： myocardial protection cardiopulmonary bypass cardiac surgery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental and Clinical Research of myocardial protection Effect Using MHBC Perfusion

引用

South China Journal of Cardiology 2004年第1期5卷 33-37页

作者：孟春营吴若彬罗滨温定国 DepartmentofThoracicandCardiacSurgery ShenzhenPeople’sHospitalShenzhen518020PRChina DepartmentofCardiacSurgery GuangdongProvincialCardiovascularInstituteGuangzhou510100PRChina

Objectives To determine themyocardium -protecting effect of medium hypothermalblood cardioplegia (MHBC); further demonstrates thatthe optimal temperature between these hypothermaland normothermic can overcome the disadvantages;and thus discovers a more effective myocardium pro-tecting method. Methods Section 1: 14 mongreldogs (15-20 kg) were randomly divided into twogroups: experimental group and control group; car-dialpulmonary bypass was conventionally instituted,moderate hypothermia blood cardioplegia was used inexperimental group, Blood samples from right atriumtaken for examination of lactate dehydrogenase (LDH)creatine kinase(CK-MB) and Topin Ⅰ(cTn-Ⅰ). speci-mens of left ventricular subendocardial myocardiumwere biopsied to observe changes of ultrastructure.Section 2: 24 patients were randomly divided into twogroups and both groups received two types of treat-ment (same as Section 1) after aorta cross-clamp(ACC). Biochemical index and Clinical observationwere caculated as the indicators. Results In the ex-perimental research, LDH, CK-MB, cTn-Ⅰ were foundincreased afer reperfusion in both groups, but the ex-tent of changes in experimental group is tiny (statisti-cal difference). Compared with control group the effectof MHBC on cardial function is litile; the ultrastruc-ture. of cardiac muscle has no obvious change. In theclinical research, compared the test results of venousblood drawn before CPB, after beating recovery andafter CPB, CBC perfused group (LDH, CK-MB leak-age and cTn-Ⅰ value increase.) compared with MHBCperfused group had no remarkable difference (P>0.05), but at the result of clinical observation: MHBCperfused group had re

关键词： Moderate hypothermia blood cardioplegia myocardial protection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Warm Blood Cardioplegic Solution on myocardial protection

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 1995年第4期15卷 212-216页

作者：杜心灵蓝鸿钧孙宗全 Institute of Cardiovascular Diseases Tongji Medical University Wuhan

To evaluate the effects of warm blood cardioplegic solution on myocardial protection, normothermic induction and terminal perfusion of oxygenated blood cardioplegia in combination with intermittent administration of cold blood cardioplegia during ischemia were studied in an isolated working rat heart *** experimental protocol consisted of a 120 min cardioplegic arrest followed by 45 min normothermic reperfusion. myocardial content of adenosine triphosphate (ATP), recovery of the left ventricular function, release of creatine phosphokinase (CPK) and ultrastructure of myocardium were assessed before and after ischemia. The results showed that the hearts preserved with warm blood cardioplegic induction and terminal perfusion had significantly higher levels of ATP,better recovery of cardiac function and lower releases of CPK than those receiving cold blood cardioplegia alone, with myocardial tissue being of generally normal structure. These findings suggest that warm induction and terminal perfusion of blood cardioplegic solution can accelerate myocardial metabolic and functional recovery, preserve high-energy phosphate, reduce myocardial injury and enhance myocardial protection.

关键词： warm blood cardioplegic solution cold blood cardioplegic solution myocardial protection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Roles of Zn2+ and mPTP in resveratrol-induced myocardial protection against endoplasmic reticulum stress

引用

中国药理学与毒理学杂志 2019年第10期 797-797页

作者： HE Yi-fei FU Yu ZHAO Yang LIU Yu-lin XI Jin-kun North China University of Science and Technology

OBJECTIVE To investigate resveratrolinduced myocardial protection against endoplasmic reticulum stress(ERS), focusing on the roles of Znand the mitochondrial permeability transition pore(m PTP).METHODS H9c2 cardiac cell were cultured in DMEM,ERS was induced by 2-deoxy-d-glucose(2-DG), resveratrol/ZnClwas pretreated for 20 min, the Znchelator TPEN and inhibitors were applied for 10 min before resveratrol/ZnCl. Cell viability/toxicity were measured by the MTT/LDH kit. The expressions of endoplasmic reticulum chaperone GRP 78/94, ERS-related apoptosis proteins CHOP, caspase 12, JNK and Protein Kinase pathway(ERK, PI3K/AKT, GSK-3β) phosphorylation were detected by Western blotting. The expressions of GRP 94 and JNK were detected by immunocytochemistry. The m PTP opening and intracellular Znconcentration were evaluated by measuring the mitochondrial membrane potential(ΔΨm) with TMRE and Newport Green DCF fluorescent intensity by laser confocal microscopy. RESULTS 2-DG significantly enhanced cell toxicity and decreased *** reversed the action of 2-DG. Resveratrol markedly inhibited GRP 78/94, CHOP, caspase 12, JNK expressions, which were blocked by TPEN, ERK inhibitor PD98059, GSK-3β inhibitor SB216763 and ERK/GSK-3β siRNA. In addition, resveratrol significantly increased phosphorylated ERK and GSK-3β. AKT inhibitor LY294002 and AKT siRNA were not altered the action of resveratrol. Resvetrol prevented 2-DG-induced m PTP opening and increased intracellular Znconcentration, which were further abrogated by PD98059, SB216763 and ERK/GSK-3β siRNA. CONCLUSION These data suggest that resveratrol mobilize intracellular Znand protect cardiac cells against ERS by preventing the m PTP opening through the ERK/GSK-3β pathway. The important regulator of the PI3K/AKT signaling may not be involved in the action of resveratrol.

关键词： resveratrol zinc ion endoplasmic reticulum stress mitochondrial permeability transfer pore myocardial protection

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Blocking the Aryl Hydrocarbon Receptor Alleviates myocardial Ischemia/Reperfusion Injury in Rats

引用

Current Medical Science 2022年第5期42卷 966-973页

作者： Jin-xu WANG Bei-bei WANG Shu-zhang YUAN Ke XUE Jin-sheng ZHANG Ai-jun XU Department of Anesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Anesthesiology Huashan Hospital of Fudan UniversityShanghai 200040China Henan University of Traditional Chinese Medicine Zhengzhou 450000China

Objective Restoring the blood perfusion of ischemic heart tissues is the main treatment for myocardial ***,the accompanying myocardial ischemia reperfusion injury(IRI)would aggravate myocardial *** studies have confirmed that aryl hydrocarbon receptor(AhR)is closely correlated to kidney and intestinal *** present study aimed to explore the relationship between AhR and myocardial *** An oxygen glucose deprivation/reoxygenation(OGD/R)model of H9c2 cells and an ischemia/reperfusion(I/R)model of Sprague-Dawley rat myocardium were ***/R cells and myocardial IRI rats were treated with different concentrations of the AhR antagonist CH-223191 or agonist 6-formylindolo[3,2-b]carbazole(FICZ).Under the conditions of normoxia and hypoxia/reoxygenation,the activity of cardiomyocytes,lactate dehydrogenase(LDH)and cell reactive oxygen species(ROS)were *** rats,myocardial pathological damage and markers of myocardial injury were *** According to the results of the cell viability,LDH and ROS tests in vitro,both CH-223191 and FICZ showed no myocardial protection under OGD/R ***,the histological staining and analysis of myocardial injury marker LDH in vitro revealed that CH-223191 could significantly reduce the myocardial *** AhR exhibited a different effect on myocardial IRI in vitro and in *** vivo,CH-223191 could significantly alleviate the myocardial IRI,suggesting that inhibition of AhR may play a role in myocardial protection,and AhR may serve as a potential treatment target for myocardial IRI.

关键词： aryl hydrocarbon receptor ischemia/reperfusion injury myocardial protection CH-223191 6-formylindolo[3,2-b]carbazole

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

protection of cultured myocardial cells by warm blood cardioplegia

引用

空军军医大学学报 2000年第5期 687-687页

作者： LITong,LIUWei-Yong,TANHong-Mei,CHENGang

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Passive graft perfusion in off-pump coronary artery bypass grafting

引用

Chinese Medical Journal 2007年第3期120卷 192-196页

作者： LU Feng JI Bing-yang LIU Jin-ping LIU Ming-zheng WANG Gu-yan HU Sheng-shou Department of Cardiovascular Surgery Department of Cardiopulmonary Bypass Department of An esthesiology Cardiovascular Institute ＆ Fuwai Hospital Peking Union MedicalCollege ＆ Chinese Academy of Medical Sciences Beijing 100037China Department of Pediatrics Penn State College of Medicine USA

Background myocardial protection during off-pump coronary artery bypass grafting （OPCABG） is a multifactorial problem in which maintaining stable systemic hemodynamics is very important. In this study passive graft perfusion （PGP） was applied to investigate the effect during and after OPCABG as evaluated by cardiac troponin I （CTnl） and hemodynamic indexes. Methods Thirty first-time patients underwent OPCABG under one surgeon. They were randomly divided into two groups： The passive graft perfusion group （PGP, n=15） received distal coronary perfusion during the anastomosis and immediate graft perfusion after the distal anastomosis. The control group, no graft perfusion group, （NGP, n=15） received no graft perfusion after the distal anastomosis. The results of the two protocols were evaluated by concentration of CTnl and hemodynamic indexes before induction and after operation. Results There were no statistically significant differences between these two groups in their perioperation parameters. The level of CTnl increased postoperatively, reached its peak at 6 hours （P〈0.05） and recovered by the 6 days postoperative. Compared with the control group the concentration of CTnl in the PGP group was significantly lower at 6 and 24 hours （P〈0.01）. Compared with the NGP group, cardiac index （CI） in the PGP group was higher at 12 and 24 hours after operation （P〈0.05）. The period of mechanical ventilation was significantly shorter in the PGP group than in the NGP group （P〈0.05）. Conclusion PGP can increase the flow to the myocardium and shorten the heart ischemia time, thus maintain stable systemic hemodynamics, supply a satisfactory CI after surgery and improve surgery outcome.

关键词： passive graft perfusion coronary artery bypass grafting myocardial protection off-pump

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protective Effects of Hyperpolarizing Cardioplegia with Pinacidil on Myocardium in Rats

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第1期22卷 31-33页

作者：胡志伟张凯伦汪文东 Department of Cardiovascular Surgery Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan

Whether the ATP sensitive potassium channel opener pinacidil can provide myocardial protective effects in prolonged isolated global ischemic rat heart was investigated. On modified isolated rat working heart model, 40 hearts were divided into four groups randomly: Hyperpolarized arrest H K solution containing pinacidil (50 μmol/L) (P1 and P2) and depolarized arrest St. Thomas' solution (S1 and S2) subjected to 15 ℃ hypothermia, 60 min (P1 and S1) or 120 min (P1 and S2) of ischemia and 30 min reperfusion. The experimental indices included cardioplegic efficiency, cardiac function, coronary blood flow, myocardial enzyme release, myocardial water and ATP content. Hyperpolarized arrest provided significantly better recovery of cardiac function than depolarized arrest. Postischemic coronary flow and myocardial ATP content were higher. The arrest time of electro mechanical activities were longer than depolarized arrest. There were no differences among the groups in myocardial water contents. The hyperpolarized arrest solution containing pinacidil can provide a marked myocardial protective effect during prolonged hypothermic myocardial ischemia.

关键词： myocardial protection hyperpolarized cardioplegia depolarized cardioplegia pinacidil

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：