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Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 669-672页

作者： Yi-Qian Liu Wei-You Zhu Yong-Qian Shu Yan-Hong Gu Department of Oncology the First Affiliated Hospital of Nanjing Medical University

mycosis fungoides is a common cutaneous T-cell lymphoma,which is usually characterized by chronic,indolence progression,with absence of typical symptoms in early stage,metastasis to lymph nodes,bone marrow and visceral organs in later stage and ultimately progression to systemic *** can result in secondary skin infection which is a frequent cause of death. At present,no curative therapy *** purpose is to induce remission,reduce tumor burden and protect immune function of patients.A case of patient with advanced severe mycosis fungoides receiving CHOP plus interferon a -2a was reported here,with disease-free survival of 7 months and overall survival of over 17.0 months,and current status as well as developments of mycosis fungoides were briefly introduced.

关键词： mycosis fungoides Cutaneous T-cell lymphoma Chemotherapy

mycosis Fungoides in Relation to Environmental and Occupational Exposures: A Case-Control Study in the Tunisian Center

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International Journal of Clinical Medicine 2018年第6期9卷 528-539页

作者： I. Kacem M. Hafsia L. Bousoffara N. Ghariani Fetoui O. El Maalel W. Boughattas N. Ghariani M. Denguezli A. Brahem S. El Guedri H. Kalboussi S. Chatti N. Mrizak Occupational Medicine Department Teaching Hospital Farhat Hached Sousse Tunisia Dermatology Department Teaching Hospital Farhat Hached Sousse Tunisia

Introduction: The mycosis fungoides (MF) is the most common cutaneous T-cell lymphomas representing about 50% of all cutaneous lymphomas. Its pathogenesis remains poorly understood. Thus, its rising incidence rates call for an explanation. Several environmental and occupational factors have been implicated in the pathogenesis of this disease. Objective: To determine the potential occupational factors correlated in the occurrence of MF. Methods: Case-control study was carried out at the teaching Hospital Farhat Hached of Sousse (Tunisia) to investigate associations of MF and occupational risk factors. A questionnaire on lifetime job history was administered to 24 cases and controls. Cases were patients with MF and whose diagnosis was suspected by a dermatologist and confirmed by pathological examination. Controls were patients consulting in the occupational medicine department and matched to cases by age and gender. Bivariate analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Results: The average age of onset of the disease was 55.41 ± 17.4 years with a sex ratio of 2.42. We found an increased risk of MF associated with tobacco consumption higher than 40 Pack-year (OR = 6.6;95% CI = 1.22 to 35.4), exercise in the textile sector (OR = 9.4;CI = 1.06 to 84.3) and exposure to diesel exhaust (OR = 9.47;95% CI = 1.06 to 84.3). Conclusion: Occupational factors could play a role in the pathogenesis of MF. Regarding our study, smoking, working in the textile industry and exposure to diesel exhaust appear to be involved in the pathogenesis of MF. Further investigation is needed to confirm these findings.

关键词： mycosis Fungoides Occupational Factors Tobacco Textile Sector Diesel Exhaust

mycosis Fungoides in Iraqi Patients—Clinical, Histopathological and Immunohistochemical Study

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Journal of Cosmetics, Dermatological Sciences and Applications 2015年第2期5卷 116-124页

作者： Hayder R. Al-Hamamy Khalifa E. Sharquie Adil A. Noaimi Waqas S. Abdulwahhab Scientific Council of Dermatology and Venereology Iraqi Board for Medical Specializations Baghdad Teaching Hospital Medical City Baghdad Iraq Scientific Council of Dermatology and Venereology Iraqi and Arab Board for Medical Specializations Department of Dermatology College of Medicine University of Baghdad Baghdad Iraq Arab Board for Medical Specializations Department of Dermatology and Venereology Baghdad Teaching Hospital Medical City Baghdad Iraq

Background: mycosis fungoides (MF) is not an uncommon T-cell lymphoma in Iraqi population which is increasing over years. There are many diagnostic techniques to confirm the diagnosis including histopathological and immunohistochemical tests. Objectives: To evaluate all cases of MF including clinical, histopathological and immunohistochemical tests with CD markers. Patients and Methods: This clinical, histopathological, immunohistochemical outpatient based study took place in the Department of Dermatology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq during the period from May 2012-September 2013. Twenty five patients with MF were included in the present work. History was obtained from each patient regarding all socio-demographic aspects related to the disease. Also, clinical evaluation was carried out for all patients. Incisional biopsies for ordinary histopathology and immunohistochemical tests were done. Then staging was carried out depending on TNMB classification for all patients. Results: All cases of MF were confirmed after clinical evaluation, histopathology and immunohistochemical examination. Male to female ratio was 1.5:1. The mean age of onset at presentation was 47.45 ± 16.9 years. Itching was found in 84% of cases. The patch stage was seen in 36% patients. The hypopigmentaed MF was presented in 12% cases. The lower extremities were seen in 80%. Lymph node involvement as a manifestation of the disease was seen in 44% cases. The histopathological features of MF went parallel with the clinical stage of disease. Immunohistochemical study aids in the diagnosis of patch and erythrodermic stages. The most patients presented with stage IB (36%). Conclusion: MF seems to be not uncommon problem in Iraqi population and is increasing over years. The disease was diagnosed early commonly with patch stage (stage IB) while hypopigmented MF was not a common variant when compared with neighboring countries.

关键词： mycosis Fungoides T-Cell Lymphoma Immunohistochemical Examination TNMB Classification

mycosis Fungoides: Epidemiology in Isfahan, Iran

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第3期2卷 229-233页

作者： Farahnaz Fatemi Naeini Jamshid Najafian Mansoor Salehi Zahra Azimi Parvin Rajabi Department of Genetics and Molecular Biology Medical School Isfahan University of Medical Sciences Isfahan Iran Isfahan Cardiovascular Research Center Isfahan Cardiovascular Research Institue Isfahan University of Medical Sciences Isfahan Iran Isfahan University of Medical Sciences Isfahan Iran Skin and Stem Cell Research Center Tehran University of Medical Sciences Tehran Iran Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences Isfahan Iran

Background: mycosis Fungoides (MF) is the most common and indolent form of Cutaneuse T-cell Lymphomas (CTCL), that usually occurs in old adults. Objectives: To determine epidemiologic features and patients characteristics of MF in Isfahan (Iran). Methods: We performed a retrospective study in MF clinic of alzahra hospital that is the main center for treatment of MF patients in Isfahan (Iran) and evaluated clinicopathologic features. Results: In 3 years 25 patients were referred to Alzahra MF clinic. 18 patients diagnosed as MF. Seven (38.9%) patients were male and 11 (61.1%) were female with male to female ratio of 1:1.57. The mean age of patients was 41.06 years. 88.9% of our patients were in stages ΙA and ΙB. Conclusion: Most of our patients presented in early stages that were similar to other studies, while male: female ratio is different from other studies.

关键词： mycosis Fungoides Epidemiology Clinical Features Iran

Pancreatic metastasis from mycosis fungoides mimicking primary pancreatic tumor

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World Journal of Gastroenterology 2016年第12期22卷 3496-3501页

作者： Paola Ceriolo Valentina Fausti Elisa Cinotti Silvia Bonadio Lizzia Raffaghello Giovanna Bianchi Giulio Fraternali Orcioni Roberto Fiocca Franco Rongioletti Vito Pistoia Giacomo Borgonovo Course in Paediatric Science Fetal-Perinatal and Paediatric Pathology University of Genoa Pathology Unit Istituto Giannina Gaslini Section of Dermatology IRCCS AOU San Martino-IST Pathology Unit IRCCS AOU San Martino-IST Laboratory of Oncology Istituto Giannina Gaslini Pathology Unit IRCCS AOU San Martino-IST and University of Genoa Surgery Unit IRCCS AOU San Martino-IST and University of Genoa

mycosis fungoides(MF) is a cutaneous T-cell lymphoma that can undergo local progression with possible systemic dissemination. We report a case of a patient affected by MF with a pancreatic mass that was a diagnostic challenge between primitive tumor and pancreatic metastasis from MF. Clinical setting findings and imaging studies raised the suspicion of a pancreatic primary neoplasm. A diagnostic clue was provided by the combined histomorphologic/immunohistochemical study of pancreatic and cutaneous biopsies, which revealed a pancreatic localization of MF. Considering the rarity of metastatic localization of MF to the pancreas, we next investigated whether chemokinechemokine receptor interactions could be involved in the phenomenon to provide new insight into the possible mechanisms underlying metastatic localization of MF to the pancreas. Histological analyses of archival pancreatic tissue demonstrated that glucagon-secreting cells of the pancreatic islets expressed the CCL27 chemokine, which may have attracted in our case metastatic MF cells expressing the complementary receptor CCR10.

关键词： Differential diagnosis Pancreatic mass Extracutaneous localization mycosis fungoides CCL27 CCR10

Epidemiological Investigation of mycosis Infection Among Full-term Pregnant Women

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Chinese Journal of Sexually Transmitted Infections 2001年第1期 51-53页

作者：刘植华邓英李晴 Department of Obstetrics and Gynecology Women and Children’s Hospital Department of Obstetrics and Gynecology Women and Children’s Hospital Shenzhen 518028 China

Objectie: To find out the basic conditions of mycosis infectionof full-term pregnant women. Methods: Fungus isolation and identification from the vaginalsecretions and oral specimens from 208 full-term pregnantwomen were carried out by fungi culture and identifiedfollowing standard biological practice. Results: The positive detection rate for vaginal fungi was51.92% and for oral fungi it was 47.59%. 20.19% had fungi inboth the vaginal and oral cavity. The fungi found were mainly ofthe species Candida albicans. Conclusion: The prevalence of fungal mycosis infection infull-term pregnant women was higher than that usually found innon-pregnant women. In order to prevent furthercomplications and materal-child transmission, serious attentionshould be paid to this high prevalence finding.

关键词： Fungi mycosis Pregnancy Epidemiology

Interstitial mycosis Fungoides with Systemic Sclerosis-Like Features: A Case Report

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International Journal of Dermatology and Venereology 2019年第3期2卷 183-185页

作者： Qiu-Ju Miao Yi-Fei Wang Yi Geng Xiu-Lian Xu Department of Pathology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Introduction mycosis fungoides (MF) is the most common form of cutaneous lymphoma,accounting for almost 50% of all types.1 MF occasionally manifests as the interstitial lymphocytic infiltrate that mimics inflammatory morphea,interstitial granulomatous dermatitis,and interstitial granuloma annulare,and this rare histopathological variant has been termed interstitial mycosis fungoides (IMF).IMF can be considered as a transient histopathological pattern in conventional MF,with common clinical presentation as patches and plaques.

关键词： Introduction mycosis fungoides (MF) cutaneous lymphoma Systemic Sclerosis-Like Features

Bronchoscopy and Pathology Findings in an Unusual Case of Allergic Bronchopulmonary mycosis

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Infectious Diseases & Immunity 2021年第3期1卷 174-178页

作者： Yongqun Li Caiyun Zhang Chunyang Zhang Respiratory and Critical Care Department Sixth Medical Center of PLA General HospitalBeijing 100039China

The diagnosis of allergic bronchopulmonary mycosis(ABPM)is usually made on clinical,serologic,and roentgenographic ***,the indicators in such diagnostic criteria still lack specificity,which results in a high rate of misdiagnosis.A 47-year-old woman was diagnosed with“tuberculosis”or“pneumonia”for 10years and after thoracoscopic right upper lung resection the following chest CT showed right lung *** sputum was seen in the right bronchus via *** the surgical pathology specimen,the bronchi were found to be generally cystic dilated,and a large amount of mucus was retained and formed a mucus *** final diagnosis of the case was *** current diagnostic criteria of ABPM do not emphasize the role of bronchoscopy and pathological examination,but bronchoscopy and pathological examination still have important value for some atypical cases with suspected ABPM.

关键词： Aspergillosis,allergic bronchopulmonary Bronchoscopy mycosis Pathology

Hypopigmented mycosis Fungoides in a 7-Year-Old Boy

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第2期2卷 64-67页

作者： Felipe Nazareth Maria Victoria Quaresma Fred Bernardes Carlos Gustavo Carneiro Castro Edilbert Pellegrini Nahn Jose Augusto da Costa Nery Mayra Carrijo Rochael Omar Lupi Department of Dermatology Policlínica Geral do Rio de Janeiro Rio de Janeiro Brazil

Hypopigmented mycosis fungoides (HMF) is an uncommon variant of cutaneous T-cell lymphoma. It is more frequent in dark-skinned people, particularly children. The HMF diagnose is difficult, especially in early stages because this condition resembles benign skin diseases. Thus is histopathological analysis very important for the diagnosis. We report a case of a 7-year-old child with widespread HMF confirmed by histopathology that showed cells tagging along the dermal/epidermal junction and extending into the epidermis in a pattern of epidermotropism and focal cell aggregates in the epidermis (Pautrier’s microabscess). We demonstrate the importance of clinical suspicion for this cutaneous neoplasia in patients with hypopigmentated lesions.

关键词： Hypopigmented Child mycosis Fungoides

High Dose Rate (HDR) Brachytherapy for mycosis Fungoides of the Wrist

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International Journal of Clinical Medicine 2015年第3期6卷 154-157页

作者： Gaurav Shukla Virginia Lockamy James Keller Joya Sahu Barbara Pro Onder Alpdogan Wenyin Shi Department of Radiation Oncology Thomas Jefferson University Philadelphia PA USA Department of Dermatology Thomas Jefferson University Philadelphia PA USA Department of Medical Oncology Thomas Jefferson University Philadelphia PA USA

mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma accounting for approximately half of all cutaneous T-cell lymphomas. Radiation therapy is an effective treatment for early stage MF and has been shown to result in long-term disease-free intervals, with even curative potential. Radiation is also effective as palliative treatment for the localized lesion resistant to the topic or other treatments. In the current study, we report using high dose rate (HDR) radiation treatment for a patient with resistant mycosis fungoides involving the wrist. We report a convenient treatment with an ideal radiation dose distribution, and a excellent clinical outcome.

关键词： mycosis Fungoides Cutaneous T-Cell Lymphoma Radiation Therapy High Dose Rate (HDR)