Mycosis Fungoides in Iraqi Patients—Clinical, Histopathological and Immunohistochemical Study
Mycosis Fungoides in Iraqi Patients—Clinical, Histopathological and Immunohistochemical Study作者机构：Scientific Council of Dermatology and Venereology Iraqi Board for Medical Specializations Baghdad Teaching Hospital Medical City Baghdad Iraq Scientific Council of Dermatology and Venereology Iraqi and Arab Board for Medical Specializations Department of Dermatology College of Medicine University of Baghdad Baghdad Iraq Arab Board for Medical Specializations Department of Dermatology and Venereology Baghdad Teaching Hospital Medical City Baghdad Iraq
出 版 物：《Journal of Cosmetics, Dermatological Sciences and Applications》 (化妆品、皮肤病及应用期刊（英文）)
年 卷 期：2015年第5卷第2期
页 面：116-124页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Mycosis Fungoides T-Cell Lymphoma Immunohistochemical Examination TNMB Classification
摘 要：Background: Mycosis fungoides (MF) is not an uncommon T-cell lymphoma in Iraqi population which is increasing over years. There are many diagnostic techniques to confirm the diagnosis including histopathological and immunohistochemical tests. Objectives: To evaluate all cases of MF including clinical, histopathological and immunohistochemical tests with CD markers. Patients and Methods: This clinical, histopathological, immunohistochemical outpatient based study took place in the Department of Dermatology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq during the period from May 2012-September 2013. Twenty five patients with MF were included in the present work. History was obtained from each patient regarding all socio-demographic aspects related to the disease. Also, clinical evaluation was carried out for all patients. Incisional biopsies for ordinary histopathology and immunohistochemical tests were done. Then staging was carried out depending on TNMB classification for all patients. Results: All cases of MF were confirmed after clinical evaluation, histopathology and immunohistochemical examination. Male to female ratio was 1.5:1. The mean age of onset at presentation was 47.45 ± 16.9 years. Itching was found in 84% of cases. The patch stage was seen in 36% patients. The hypopigmentaed MF was presented in 12% cases. The lower extremities were seen in 80%. Lymph node involvement as a manifestation of the disease was seen in 44% cases. The histopathological features of MF went parallel with the clinical stage of disease. Immunohistochemical study aids in the diagnosis of patch and erythrodermic stages. The most patients presented with stage IB (36%). Conclusion: MF seems to be not uncommon problem in Iraqi population and is increasing over years. The disease was diagnosed early commonly with patch stage (stage IB) while hypopigmented MF was not a common variant when compared with neighboring countries.
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