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mycophenolate mofetil as a treatment for refractory idiopathic thrombocytopenic purpura

Acta Pharmacologica Sinica 2005年第5期26卷 598-602页

作者： Wang-gang ZHANG~2,Lei JI,Xing-mei CAO,Yin-xia CHEN,Ai-li HE,Jie LIU,Wan-hong ZHAO,San-peng ZOU~2Department of Hematology,the 2nd Hospital of Xi’an Jiaotong University Xi’an 710004,China DepartmentofHematology the2ndHospitalofXi'anJiaotongUniversityXi'an710004China

Aim:To determine whether mycophenolate mofetil(MMF)has beneficial effectson refractory idiopathic thrombocytopenic purpura(ITP)and the correspondingcellular ***:Twenty refractory ITP patients resistant to corti-costeroid and/or splenectomy and chemical therapy were given MMF 1.5-2.0g/dorally for a 2 to 4-month *** immunoglobulin was detected by ***-associated antibodies(PAIgG)were assayed by enzyme-linked immunosorbant *** immunophenotypic analysis was performed ona flow cytometer and cell apoptosis was detected with transferase mediated dUTPbiotin nick end labeling(TUNEL)***:Sixteen of the 20(80%)pa-tients had responses to MMF treatment;9(45%) achieved a complete response,4(20%)achieved a partial response,and 3(15%)achieved a minor *** effects were found to be better in male patients than female *** number of CD3~+ peripheral blood cells(PBCs)and CD4~+ PBCs increased andthe number of CD8~+ PBCs *** plasma level of IgG,IgM,IgA andplatelet associated IgG(PAIgG)decreased in 86% of the *** assayshowed that mycophenolate acid(MPA)0.1 mmol/L induced apoptosis of periph-eral blood mononuclear cells isolated from refractory ITP *** apoptosisrate was increased in male patients after treatment with MPA,but was unchangedin female ***:Therapy for a period of 8 to 16 weeks with median-dose of MMF was valuable for the treatment of refractory ITP.

关键词： mycophenolate acid idiopathic thrombocytopenic purpura male female apoptosis

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