Mycophenolate mofetil as a treatment for refractory idiopathic thrombocytopenic purpura

作     者：Wang-gang ZHANG~2,Lei JI,Xing-mei CAO,Yin-xia CHEN,Ai-li HE,Jie LIU,Wan-hong ZHAO,San-peng ZOU~2Department of Hematology,the 2nd Hospital of Xi’an Jiaotong University Xi’an 710004,China 

作者机构：DepartmentofHematologythe2ndHospitalofXi'anJiaotongUniversityXi'an710004China 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2005年第26卷第5期

页      面：598-602页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Project supported by a grant from the Clinical Key Programmer Foundation of the Ministry of Public Health of China(№ 20012131) 

主　　题：mycophenolate acid idiopathic thrombocytopenic purpura male female apoptosis 

摘      要：Aim:To determine whether mycophenolate mofetil(MMF)has beneficial effectson refractory idiopathic thrombocytopenic purpura(ITP)and the correspondingcellular ***:Twenty refractory ITP patients resistant to corti-costeroid and/or splenectomy and chemical therapy were given MMF 1.5-2.0g/dorally for a 2 to 4-month *** immunoglobulin was detected by ***-associated antibodies(PAIgG)were assayed by enzyme-linked immunosorbant *** immunophenotypic analysis was performed ona flow cytometer and cell apoptosis was detected with transferase mediated dUTPbiotin nick end labeling(TUNEL)***:Sixteen of the 20(80%)pa-tients had responses to MMF treatment;9(45%) achieved a complete response,4(20%)achieved a partial response,and 3(15%)achieved a minor *** effects were found to be better in male patients than female *** number of CD3~+ peripheral blood cells(PBCs)and CD4~+ PBCs increased andthe number of CD8~+ PBCs *** plasma level of IgG,IgM,IgA andplatelet associated IgG(PAIgG)decreased in 86% of the *** assayshowed that mycophenolate acid(MPA)0.1 mmol/L induced apoptosis of periph-eral blood mononuclear cells isolated from refractory ITP *** apoptosisrate was increased in male patients after treatment with MPA,but was unchangedin female ***:Therapy for a period of 8 to 16 weeks with median-dose of MMF was valuable for the treatment of refractory ITP.