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Open Journal of Ophthalmology 2023年第1期13卷 37-47页

作者： Ayse Oner Neslihan Sinim Kahraman Department of Ophthalmology Kayseri Acibadem Hospital Kayseri Turkey

Aim: To establish a useful and objective classification for retinitis pigmentosa (RP) to evaluate the disease severity. Methods: This is a retrospective cross-sectional study. Visual acuity (VA), visual field (VF) width, ellipsoid zone width on optic cohorence tomography (OCT) and multifocal electroretinography (mf ERG) values were obtained from medical records of patients with RP. A scoring criterion was developed wherein each variable was assigned a score from 0 to 5 depending on its distribution. The cumulative score (from 0 to 20) was used to classify disease severity from grade 0 to 5. The scores were correlated with each other and the final grade. Results: Data of 152 eyes of 92 patients who had the results of all tests were reviewed. The mean age was 41.2 years. The mean VA of the patients was 0.13 ± 0.16 Snellen lines. The majority of patients had a VA less than 20/40 (88.6%), a visual field smaller than 20˚ (78%), and an ellipsoid zone width smaller than 7˚ (84.4%). The majority of the patients (85.4%) were in advanced stage of the disease (Grade 4 and 5). Conclusions: We present a simple, objective and easy to use disease severity classification for RP which can be used to categorize patients and to evaluate and compare treatment results.

关键词： Classification multifocal electroretinography Retinitis Pigmentosa Visual Field Visual Function

Neuroretinal dysfunction in patients affected by neurofibromatosis type 1

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 773-779页

作者： Antonietta Moramarco Luca Lucchino Fabiana Mallone Michela Marcelli Ludovico Alisi Vincenzo Roberti Sandra Giustini Alessandro Lambiase Marcella Nebbioso Department of Sense Organs Sapienza University of RomePoliclinico Umberto IRome 00161Italy Department of Dermatology and Venereology Sapienza University of RomePoliclinico Umberto IRome 00161Italy

AIM:To examine neuroretinal function by using the multifocal electroretinography(mf ERG)test in patients with neurofibromatosis type 1(NF1)without optic pathway gliomas(OPGs).METHODS:This study was conducted on 35 patients(35 eyes)with NF1 and 30 healthy subjects(30 eyes)for the control *** subject underwent a complete ophthalmological examination including spectral domainoptical coherence tomography(SD-OCT)and mf *** 1.5-Tesla magnetic resonance imaging(MRI)scan of the brain was performed in NF1 patients to assess the presence of *** participants were recruited having a best corrected visual acuity(BCVA)of no less than 20/20 in each *** amplitude and implicit time of the P1 wave(first-order Kernel component)were evaluated on mf *** analysis was carried out in the two central degrees and in the four quadrants from two to 25 degrees of visual ***:Statistically significant results were obtained for the P1 wave amplitudes in the 4 quadrants in NF1 patients compared to healthy controls,while the reduction was not significant in the 2 central degrees between the groups.A statistically significant difference was observed among the P1 wave amplitudes as recorded in the 4 quadrants within the NF1 group,with lower amplitudes detected in the nasal *** differences in the implicit times were recorded in the 2 central degrees and in the 4 quadrants as compared between NF1 patients and ***:Impaired neuroretinal function in NF1 patients is expressed in a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees on mf *** intracellular signal transduction due to abnormal neurofibromin-mediated cyclic adenosine monophosphate(c AMP)generation,can be *** possible use of mf ERG as subclinical retinal damage indicator has a potential utility in clinical practice for the follow-up of NF1 patients.

关键词： neurofibromatosis type 1 multifocal electroretinography neuroretinal function optic pathway gliomas neurofibromin

Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1592-1596页

作者： Hong-He Xia Jia-Lin Chen Hao-Yu Chen Hong-Jie Lin Joint Shantou International Eye Center Shantou University and the Chinese University of Hong KongShantou 515041Guangdong ProvinceChina

AIM:To analyze the correlation between macular morphology and function in eyes with diabetic macular edema(DME).METHODS:Fifty-five eyes with different visual acuity(VA)of 32 patients who suffered from DME were analyzed using multifocal electroretinography(mfERG)and optical coherence tomography(OCT).The parameters of mfERG including implicit times and response amplitude were compared to those of 50 normal eyes of 36 age-matched *** analysis was performed between VA,the parameters of mfERG including implicit times and response amplitude,and the central macular thickness(CMT).RESULTS:The amplitude of N1 and P1 were significantly decreased and their latency were significantly increased in five ring regions of the retina in patients with *** was statistically significant correlation between logMAR BCVA and P1 amplitude densities in rings 1-4(r=-0.306,-0.536,-0.470,-0.362;P=0.023,0.05)in the central macular *** stepwise regression analysis showed that P1 amplitude density in ring 2 was the only contributor to the ***:It seems to be more appropriate of combining use of mfERG with OCT for the evaluation of macular function in eyes with DME.

关键词： diabetic macular edema optical coherence tomography multifocal electroretinography best-corrected visual acuity

Effect of carotenoids dietary supplementation on macular function in diabetic patients

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Eye and Vision 2017年第1期4卷 137-142页

作者： Marilita M.Moschos Maria Dettoraki Michael Tsatsos George Kitsos Christos Kalogeropoulos First Department of Ophthalmology Medical SchoolNational and Kapodistrian University of Athens6 Ikarias streetEkali14578 AthensGreece Department of Ophthalmology Medical SchoolAristotle University of ThessalonikiThessalonikiGreece Department of Ophthalmology Medical SchoolUniversity of IoanninaIoanninaGreece

Background:Diabetic retinopathy is a major cause of visual impairment and blindness among working-age people *** aim of our study was to investigate the effects of a carotenoid supplementation on retinal thickness and macular function of patients with diabetes using optical coherence tomography(OCT)and multifocal electroretinography(mfERG).Methods:A retrospective study of one hundred and twenty eyes of sixty patients age between 40 and 60 years with non-insulin dependent type 2 diabetes mellitus without diabetic retinopathy who underwent OCT and mfERG and took vitamin supplements for a period of two *** received a carotenoid supplement containing lutein(10 mg),zeaxanthin(2 mg)and meso-zeaxanthin(10 mg)once a day for two *** thickness of the fovea was evaluated using OCT and the macular function was tested by ***:OCT showed an increase in the central foveal thickness and mfERG revealed increased retinal response density within the central 13°surrounding the fovea(rings 1 to 3)at two years after the onset of carotenoids supplement ***:The use of carotenoid supplements may be of benefit for improving visual function of type 2 diabetes ***,further study is needed to assess the treatment’s long-term efficacy.

关键词： Carotenoids Diabetes mellitus Visual function multifocal electroretinography Optical coherence tomography

What is new in central serous chorioretinopathy?

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World Journal of Ophthalmology 2014年第4期4卷 113-123页

作者： Michal Schaap-Fogler Rita Ehrlich Department of Ophthalmology Rabin Medical CenterPetach Tikva 49100 Israel

Central serous chorioretinopathy(CSCR) is considered a benign, self-limiting disease. However, as many as third of the patients have recurrent episodes or chronic disease that may cause significant functional impairment. New diagnostic tools and new treatment modalities are emerging in order to improve the functional outcomes of these patients. Spectral domain optical coherence tomography(SD-OCT) has the ability to image individual layers of the retina and choroid. SD-OCT images in CSCR patients have demonstrated increased subfoveal thickness measurements, high reflective deposits in areas of subretinal precipitates and changes in the Retinal pigment epithelium layers of the asymptomatic eyes of patients with supposedly unilateral CSCR. A positive correlation was found between the level of distribution to the layer of inner segment/outer segment junction of the photoreceptors and the visual impairment. Fundus autoflouresence images show a wide variety during different stages of the disease in CSCR patients. Minimal abnormalities during the early stages are followed by hyperautofluoresence in the detached area in later stages, often in a manner of inferior gravitation and at the borders of the detachments. The chronic phase is characterized by varying degrees of atrophy and areas of decreased autofluorescence surrounding areas ofchronic leaks. These changes help differentiate an active disease from an inactive state. multifocal electroretinography(mf ERG) has the ability to demonstrate a persistent depression despite the resolution of subretinal detachments. It is therefore being investigated as a follow up tool for patients with chronic CSCR. An excellent correlation was found between changes in mf ERG and visual function. Macular microperimetry, measuring retinal sensitivity within the central visual field, is intended to compensate for the underestimation of visual impairment in patients with macular diseases. Reduced retinal sensitivity was found in areas of prev

关键词： Central serous chorioretinopathy Optical coherence tomography Fundus autoflouresence multifocal electroretinography Macular microperimetry