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Frontiers of Earth Science 2017年第3期11卷 592-600页

作者： Jianwen BAI Zhenyao SHEN Tiezhu YAN State Key Laboratory of Water Environment Simulation School of Environment Beijing Normal University Beijing 100875 China

An essential task in evaluating global water resource and pollution problems is to obtain the optimum set of parameters in hydrological models through calibra- tion and validation. For a large-scale watershed, single-site calibration and validation may ignore spatial heterogeneity and may not meet the needs of the entire watershed. The goal of this study is to apply a multi-site calibration and validation of the Soil and Water Assessment Tool （SWAT）, using the observed flow data at three monitoring sites within the Baihe watershed of the Miyun Reservoir watershed, China. Our results indicate that the multi-site calibration parameter values are more reasonable than those obtained from single-site calibrations. These results are mainly due to significant differences in the topographic factors over the large-scale area, human activities and climate variability. The multi-site method involves the division of the large watershed into smaller watersheds, and applying the calibrated parameters of the multi-site calibration to the entire watershed. It was anticipated that this case study could provide experience of multi-site calibration in a large-scale basin, and provide a good foundation for the simulation of other pollutants in follow- up work in the Miyun Reservoir watershed and other similar large areas.

关键词： calibration soil and water assessment tool,Miyun Reservoir multi-site

D3Targets-2019-nCoV: a webserver for predicting drug targets and for multi-target and multi-site based virtual screening against COVID-19

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1239-1248页

作者： Yulong Shi Xinben Zhang Kaijie Mu Cheng Peng Zhengdan Zhu Xiaoyu Wang Yanqing Yang Zhijian Xu Weiliang Zhu CAS Key Laboratory of Receptor Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China Nano Science and Technology Institute University of Science and Technology of ChinaSuzhou 215123China

A highly effective medicine is urgently required to cure coronavirus disease 2019(COVID-19).For the purpose,we developed a molecular docking based webserver,namely D3 Targets-2019-nCoV,with two functions,one is for predicting drug targets for drugs or active compounds observed from clinic or in vitro/in vivo studies,the other is for identifying lead compounds against potential drug targets via *** server has its unique features,(1)the potential target proteins and their different conformations involving in the whole process from virus infection to replication and release were included as many as possible;(2)all the potential ligand-binding sites with volume larger than 200 A^3 on a protein structure were identified for docking;(3)correlation information among some conformations or binding sites was annotated;(4)it is easy to be updated,and is accessible freely to public(https://www.d3 ***/D3 Targets-2019-nCoV/***).Currently,the webserver contains 42 proteins[20 severe acute respiratory syndrome-related coronavirus 2(SARS-CoV-2)encoded proteins and 22 human proteins involved in virus infection,replication and release]with 69 different conformations/structures and 557 potential ligand-binding pockets in *** 6 examples,we demonstrated that the webserver should be useful to medicinal chemists,pharmacologists and clinicians for efficiently discovering or developing effective drugs against the SARS-CoV-2 to cure COVID-19.

关键词： COVID-19 SARS-CoV-2 Target prediction multi-conformation multi-site Docking D3Targets-2019-nCoV

基于ATE的电源芯片multi-site测试设计与实现

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电子与封装 2016年第11期16卷 14-17,26页

作者：唐彩彬中国电子科技集团公司第58研究所江苏无锡214035

介绍了电源芯片的多site测试设计与实现。基于CTA8280测试系统,通过对芯片CP(晶圆测试)要求进行分析,设计了8 site测试电路外围,能够实现对晶圆进行8 Die并行测试。测试结果显示,该方案能够有效提升该电源芯片的测试效率,降低测试成本。

关键词： CTA8280 CP测试 multi-site 测试效率

Lignin derived absorbent for efficient and sustainable CO_(2) capture

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Chinese Journal of Chemical Engineering 2023年第2期54卷 89-97页

作者： Yuandong Cui Bin He Yu Lei Yu Liang Wanting Zhao Jian Sun Xiaomin Liu School of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071China School of Life Science Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologyBeijing Engineering Research Center of Cellulose and Its DerivativesAdvanced Research Institute of Multidisciplinary ScienceBeijing Institute of TechnologyBeijing 100081China

High and cost-efficient capture of CO_(2) is a prerequisite and an inevitable path of carbon emission reduction. To address the challenges(high cost, low efficiency, less sustainability, etc.) of existing petroleum-based CO_(2) absorbents, herein, a class of efficient and sustainable lignin-based absorbents were resoundingly prepared by grafting the active amine group on a lignin derived compound vanillin and alkali lignin. The results demonstrated that vanillin modified by acrylamide achieved the excellent absorption capacity among the three absorbents, whose ability was 0.114 g CO_(2) per gram of absorbent under 25 ℃ and 100 kPa. In addition, the absorbent retained stable absorbability of CO_(2) after 6 *** absorbing capacity of the absorbent formed by the coupling of vanillin and acrylamide to CO_(2) was much greater than their own(i.e. 0 g CO_(2) ·g^(-1)vanillin, 0.01 g CO_(2) ·g^(-1) acrylamide, respectively).Detailed information revealed the multi-site synergistic absorption mechanism, in which CO_(2) has C and O double interactions with the amide group of the absorbent, and single interaction with the hydroxyl oxygen on the benzene ring of the absorbent. The absorption capacity of modified lignin for CO_(2) is as high as 0.12 g CO_(2) per gram of absorbent, which is comparable with that of model compound *** work not only provides a new idea for the design of bio-absorbents for CO_(2) capture, but explores the application potential of lignin-based materials.

关键词： Lignin(model compound) CO_(2)absorption Amide group multi-site Acid-base Hydrogen bonding

Family selection and evaluation of Larix gmelinii ***-rupprechtii(Mayr.)Pilger based on stem analysis data at multiple sites

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林业研究:英文版 2023年第5期34卷 1627-1638页

作者： Conghui Zheng Jianfeng Dai Hongjing Zhang Yuzhong Wang Zhenhua Xu Zichun Du Hebei Technical Innovation Center for Forest Improved Variety Hebei Academy of Forestry and Grassland SciencesShijiazhuang 050061People’s Republic of China

Larix gmelinii ***-rupprechtii(Mayr.)Pilger is an important native tree species in North China with advantages of fast growth,straight trunk,and good wood *** multi-year and multi-site breeding research of families of the species has not been reported *** on diameter at breast height(DBH),height and volume of 25 families on four experimental sites,we calculated variance components,genetic parameters,juvenile and mature trait correlations and made genotype main effect plus genotype×environment interaction effect(GGE)biplot based on the breeding values estimated using the method of best linear unbiased prediction(BLUP).Compared with height,DBH and volume had higher heritability and larger variation coefficients,making them the more suitable traits for family selection and *** on these,GGE biplots containing 20 combinations of site×age were drawn using data at 13 to 17 years when the interactions between family and location were *** sites classifications based on DBH,and volume were inconsistent,with two categories for DBH and one for *** Guyuan site was the most suitable with strong discriminating ability,high representativeness and stability among tree *** the ranking results of DBH and volume,families 66,76,82 and 111 were high-yielding and stable,families 78 and96 were high-yielding with above average stability,families72 and 79 were high-yielding with below average stability,whereas stability of family 100 was inconsistent between DBH and *** selection based on DBH was convenient and reliable,and can be made at seven *** study provides support for the selection of Larix gmelinii ***-rupprechtii families in Hebei province and an example for the application of stem analysis data from multiple sites in tree breeding.

关键词： Larix gmelinii var principis-rupprechtii Stem analysis multi-site Early selection Genotype main effect plus Genotype-environmental interaction effect(GGE)biplot

A relation between long-range correlation and dielectric anomaly

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Science China Mathematics 1999年第4期42卷 423-428页

作者：张磊钟维烈王春雷彭毅萍 Department of Physics Shandong University Jinan China

A double-well potential model is established to explain the dielectric anomaly of ferroelectrics. The dielectric constant consists of two parts. One part is independent of the long-range correlation, following 1/T law. The other part originates from the long-range correlation, and can be described by the correlation length well. The deviation from Curie-Weiss law in a small size sample originates from the decrease of the long-range correlation.

关键词： ferroelectrics multi-site potential dielectric anomaly long-range correlation.

The multi-frequency Vibration of the Delta Scuti Type Variable V650 Tau

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Chinese Science Bulletin 1993年第6期38卷 471-474页

作者：刘燕英蒋世仰曹明 Beijing Astronomical Observatory Academia Sinica Beijing 100080 PRC Shaanxi Observatory Lintong 710600 PRC

The STEPHI (STEllar PHotometry International) network was set up to obtain long runs of high quality photometry data of a representative set of δ Scuti type *** sites are involved: Observatorio del teide (hereafter OT), Tenerife, Canary Islands, Spain;Xinglong Station (hereafter XL), Hebei Province, China; Observatorio Astronomico Nacional de San Pedro Martir (hereafter SPM), Baja California Norte, Mexico. The interval of 120°in longitude between the 3 sites allows uninterrupted observations and it improves greatly the spectral window of the frequency analysis. The instrumentation is characterized by two main, choices: the four-channel photometers and the 1.5 to 2 m telescopes. The

关键词： delta Scuti variable photoelectric photometry pulsation multi-site campaign.

一种斑马鱼肝脏特异表达转基因载体的制备方法

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温州医学院学报 2012年第5期42卷 453-457页

作者：陈将飞陈元红靳大庆浙江省模式生物技术与应用重点实验室温州医学院水域科学与环境生态研究所浙江温州325035 国家遗传工程实验室复旦大学生命科学院上海200433

目的:建立一套快速制备斑马鱼肝脏特异表达转基因载体的新方法。方法:首先利用multi-site gateway技术将斑马鱼肝脏脂肪酸结合蛋白(fabp10a)启动子片段与入门载体进行BP重组获得启动子的入门克隆pENTR-fabp10a,然后将目的基因克隆到载体... 详细信息

目的:建立一套快速制备斑马鱼肝脏特异表达转基因载体的新方法。方法:首先利用multi-site gateway技术将斑马鱼肝脏脂肪酸结合蛋白(fabp10a)启动子片段与入门载体进行BP重组获得启动子的入门克隆pENTR-fabp10a,然后将目的基因克隆到载体pME-MCS中形成入门克隆pENTR-interest,最后通过multi-site gateway技术将pENTR-fabp10a、pENTR-interest和含有EGFP标记基因的p3E-IRES-EGFPpA质粒在Tol2转座载体pDestTol2pA2上进行定向重组即可获得斑马鱼肝脏特异性表达转基因载体pTol2-fabp10a-interest-IRES-EGFP。本研究采用红色荧光蛋白基因DsRed2作为目的基因,用上述方法构建了转基因载体pTol2-fabp10a-DsRed2-IRES-EGFP,并将其注射至单细胞期斑马鱼胚胎中进行表达分析。结果:转基因载体pTol2-fabp10a-DsRed2-IRES-EGFP在斑马鱼肝脏组织中能实现红色和绿色荧光蛋白同步特异表达。结论:利用Tol2转座系统以及multi-site gateway技术构建斑马鱼肝脏特异性表达转基因载体是一套行之有效的方法。

关键词： To12转座子斑马鱼 multi-site gateway技术肝脏特异性表达