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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Jia-Le YANG~#,Bo XU~#,Yu-Qiu ZHANG~* Institute of Neurobiology,Fudan University,Shanghai 200032,China

＜正＞This study investigated the effects of gabapentin on thermal hyperalgesia and spinal glial activation evoked by monoarthritis（MA）.MA produced a robust glial activation of microglia and astrocytes in the spinal cord, which was associated with the development and maintenance of thermal ***（i.p.） gabapentin significantly suppressed spinal microglial activation and blocked the development of thermal hyperalgesia in MA *** showed that voltage-gated calcium channels（VGCCs）,a proposed action target of gabapentin,were wildly distributed in primary afferent fibers terminals and dorsal horn ***（CX3CL1）, a potential trigger to activate microglia,colocalized with VGCCs in superficial spinal cord,whereas its receptor CX3CR1 was mainly expressed in spinal *** data suggest that the reduction of spinal glial activation by gabapentin is likely to be due to an action on glia via diminishing the release of the"pain"neurotransmitters/ neuromodulators from primary afferent terminals and spinal nociceptive neurons.

关键词： astrocyte CX3CL1 CX3CR1 gabapentin microglia monoarthritis thermal hyperalgesia voltagegated calcium channels(VGCCs)

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Involvement of spinal neurotrophin-3 in the electroacupuncture analgesia in rat model of monoarthritis

Involvement of spinal neurotrophin-3 in the electroacupunctu...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Wen-Li MI,Xiu LI,Qi-Liang MAO-YING,Xiao-Wei WANG,Chang-Jiang YANG,Jian-Wei JIANG,Jin YU,Jun WANG,Qiong LIU,Yan-Qing WANG~*,Gen-Cheng WU~* Department of Integrative Medicine and Neurobiology,State Key Laboratory of Medical Neurobiology,Institutes of Brain Science, Shanghai Medical College,Fudan University,Shanghai 200032,China

＜正＞Although electroacupuncture（EA） is proved to be effective at pain relief in arthritis,the underlying mechanism of EA analgesia remains to be further *** analgesic effects of EA had been reported to be associated with its counter-regulation to spinal glial ***-3（NT-3） is demonstrated to be involved in pain regulation,and could be up-regulated by EA treatment after spinal cord *** an complete Freund’s adjuvant（CFA） induced inflammatory pain model in rats,the present study demonstrated that（1） Repeated EA stimulation of ipsilateral‘Huan-Tiao’（GB30） and‘Yang-Ling-Quan’（GB34） acupoints remarkably suppressed CFA-induced hyperalgesia;（2） EA treatment markedly enhanced the up-regulation of spinal NT-3 mRNA and protein level following CFA injection;（3） Antisense oligodeoxynucleotide（ODN） specifically against NT-3 intrathecally administered during EA treatment for 7 days significantly attenuated the EA analgesia;（4） The suppression of the expression of glia fibrillary acidic protein（GFAP,astrocytic marker）,OX-42（microglial marker）,as well as proinflammatory cytokines,interleukin（IL）-1β,IL-6 and tumor necrosis factor（TNF）-αin spinal dorsal horn by EA treatment was significantly attenuated following NT-3 antisense ODN *** data indicated that endogenous NT-3 might be involved in EA analgesia on inflammatory pain of rats and this effect is possibly through the inhibition of spinal glia activation as well as the proinflammatory cytokines ***,the present study may initiate the discussion on the possible roles of NT-3/glia/cytokines in the therapeutic effects of acupuncture and shed light on the deeper understanding of mechanism underlying acupuncture analgesia in arthritis.

关键词： monoarthritis electroacupuncture neurotrophin-3 glia proinflammatory cytokines.

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Involvement of spinal microglia in the anti-hyperalgesic effects of gabapentin in rat model of monoarthritis

Involvement of spinal microglia in the anti-hyperalgesic eff...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jia-Le YANG~1,Bo XU~2,Wei-Shi ZHANG~(3*),Hua XU~2,Xiao-Ming DENG~2,Yu-Qiu ZHANG~(1,*) 1 Institute of Neurobiology,Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China 2 Department of Anesthesiology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092, China 3 Department of Anesthesiology,Changhai Hospital,The Second Military Medical University,Shanghai 200433,China

＜正＞This study investigated the effects of gabapentin on spinalα2/δ-l subunit of voltage-gated calcium channels （VGCCs）,fractalkine,CX3CR1 expression levels and glial activation,as well as thermal hyperalgesia evoked by monoarthritis（MA）.MA produced a robust upregulation of VGCCsα2/δ-l subunit,fractaline,CX3CR1 expression levels,and activation of microglia and astrocytes in the spinal cord,which was associated with the development of thermal *** showed thatα2/δ-1 subunit of VGCCs,a proposed action target of gabapentin,was wildly distributed in primary afferent fibers terminals and dorsal horn ***,a potential trigger to activate microglia,colocalized withα2/δ-1 subunit of VGCCs in superficial spinal cord,whereas its receptor CX3CR1 was mainly expressed in spinal ***（i.p.）gabapentin significantly downregulated spinalα2/δ-l subunit of VGCCs and fractalkine levels,suppressed microglial activation and blocked the development of thermal hyperalgesia in MA *** data suggest that gabapentin may diminish fractalkine release in the spinal cord via modulatingα2/δ-1 subunit of VGCCs,thereby leading to the reduction in spinal glial activation and thermal hyperalgesia.

关键词： fractalkine gabapentin glial activation monoarthritis thermal hyperalgesia α2/δ-1 subunit of voltagegated calcium channels(VGCCs)

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A Large, Inflamed Knee, Pulling down the Wolf Mask

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Journal of Biosciences and Medicines 2024年第10期12卷 157-163页

作者： Bachir Mansour Diallo Jean Noel Ndour Nana Mamoudou Baba Fulgence Abdou Faye Yanidou Ndiaye Adama Wade Nelson Nandong Serigne Abdou Khadr Mbaye Adama Berthé Papa Souleymane Touré Madoky Magatte Diop Mamadou Mourtalla Ka Department of Internal Medicine Abdou Aziz Sy Hospital Tivaouane Senegal Department of Internal Medicine Mamadou Diop Hospital Dakar Senegal School of Medicine Alioune Diop University in Bambey Bambey Senegal Department of Internal Medicine Thies Regional Hospital Thies Senegal School of Medicine Iba Der Thiam University Thies Senegal

Introduction: Joint manifestations are common in systemic lupus, affecting multiple joints or just one. These manifestations are present in 95% of patients. Pseudo-septic arthritis is a subset of systemic lupus that mimics septic arthritis caused by the deposition of lipid droplets in the joint. We present the case of a patient hospitalized for mono-arthritis, which revealed systemic lupus. Observation: The patient is a 19-year-old woman, single, without children, and with no previous medical history, who was hospitalized for fever and inflammatory polyarthralgia. The clinical examination revealed an inflammatory swelling of the right knee with patellar ballottement, yellow citrine synovial fluid, an inflammatory tumor on the left arm, which was round, mobile, and fluctuating with purulent content, edema of the lower limbs, and facial puffiness, along with a systemic inflammatory response syndrome. Paraclinical examination showed hyperleukocytosis with neutrophil predominance, microcytic anemia, thrombocytopenia, antistreptolysin O (ASLO) 3, suggesting inflammatory arthritis. Bacteriological tests did not isolate any pathogens. An arthrotomy with synovial biopsy was performed, and the histopathological examination supported non-specific synovitis. A joint ultrasound showed signs of arthritis with a septic appearance. During the third hospitalization for persistent fever, she presented with facial puffiness, anemia syndrome, systemic inflammatory response syndrome, and a malar rash across the bridge of the nose. Antinuclear antibodies returned positive with a titer of 1280 and a speckled fluorescence pattern, and anti-native DNA antibodies were positive at 60.1 (normal Conclusion: Pseudo-septic arthritis is a feature of lupus that can mimic septic arthritis. Monoarticular involvement is rare but possible. The absence of pathogens and the inflammatory nature of the synovial fluid should prompt consideration of a lupus-related etiology.

关键词： Systemic Lupus Erythematosus (SLE) Pseudo-Septic Arthritis monoarthritis Autoantibodies Synovitis

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Dexmedetomidine reverses peripheral inflammation-induced acitivation of astrocytes in the spinal cord

Dexmedetomidine reverses peripheral inflammation-induced aci...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Bo XU~(1,2),Hua XU~2,Wei-Shi ZHANG~2,Xiao-Ming DENG~2,Yu-Qiu ZHANG~(1,*) 1 Institute of Neurobiology,Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China 2 Department of Anesthesiology,Changhai Hospital,The Second Military Medical University,Shanghai 200433,China

＜正＞Objective Spinal glia is of the utmost importance in developing and maintaining allodynia and hyperalgesia following tissues inflammation or *** systemically and intrathecally administered dexmedetomidine exhibited significant analgesic effect in human with inflammatory disease and animals with ***,whether the spinal glial functional states are involved in the analgesic effect of dexmedetomidine is still *** present study investigated the effects of systemic repeated administration of dexmedetomidine on thermal hyperalgesia and spinal glial activation evoked by monoarthritis（MA）.Methods monoarthritis was induced by an intra-articular injection of Complete Freund’s Adjuvant（CFA）.Paw withdrawal latency（PWL） by radiant heat was *** analyzed cell markers GFAP for astrocytes and Iba-1 for microglia in the spinal ***（1） Extensive activation of astrocytes and microglia were found in the spinal dorsal horn of MA rats.（2） Repeated intraperitoneal（i.p.） administration of dexmedetomidine（10μg/kg） significantly attenuated MA-induced thermal hyperalgesia and suppressed spinal astrocytic but not microglial activation.（3） Double immunofluorescence showed that a2ARs immunoreactivities were widely colocalized with GFAP,an astrocytic marker,but not with Iba-1,a microglial marker,in the spinal *** Blockade of spinal astrocytic activation was involved in anti-nociceptive mechanisms of dexmedetomidine.

关键词： dexmedetomidine astrocyte microglia monoarthritis thermal hyperalgesia rat

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