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Artificial liver support molecular adsorbents recirculating system therapy as a bridge to re-transplantation in two cases of long anhepatic duration

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 316-317页

作者： Yi-He Liu, Yu Wang, Li-Xin Yu, Li-Ying Sun, Bao-Lan Feng, Zhong-Yang Shen and Min-Min Wang Tianjin, ChinaTianjin Organ Transplantation Institute, Tianjin First Central Hospital, Tianjin 300192 , China Therapeutic Blood Purification Research Cen- ter , University of Rostock, Germany Tianjin Organ Transplantation Institute Tianjin First Central Hospital Tianjin 300192 China.

BACKGROUND: molecular adsorbents recirculating sys- tem (MARS) liver support therapy is the development of albumin dialysis. This study was to assess the successful ap- plication of MARS artificial liver support therapy as a bridge to re-transplantation in two cases of long anhepatic duration. METHODS: MARS therapy was given after failure plasma- exchange ( PE) treatment, which resulted in circulatory de- rangement and acute renal dysfunction in a 36-year-old male patient. Finally his uncontrolled anhepatic condition led to a successful re-transplantation. In another 48-year- old man who was diagnosed as having primary nonfunction (PNF) during the liver transplantation, 10-hour MARS treatment contributed to smooth bridging of his anhepatic phase. RESULTS: The two anhepatic patients were bridged for 26 and 17 hours respectively to re-transplantation with MARS therapy. CONCLUSION: Our experience proves that MARS artifi- cial liver can be an effective support for long time bridging PNF until re-transplantation is available.

关键词： artificial liver support liver transplantation anhepatic molecular adsorbents recirculating system

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Assessment of prognosis and curative effect in patients with chronic severe hepatitis using the model for end-stage liver disease scores

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Chinese Medical Journal 2006年第2期119卷 148-150页

作者： WU Chi-hong TIAN Geng-shan XU Xiao-yuan YU Yan-yan LU Hai-ying Department of Infectious Disease Peking University First Hospital Beijing 100034 China

Severe hepatitis is the most severe liver disease, with poor prognosis and high mortality. We explored the practical use of the model for end-stage liver disease （MELD） on clinical and the molecular adsorbents recirculating system （MARS） on chronic severe hepatitis to predict the short-term prognosis of patients with chronic severe hepatitis using the MELD score and the curative effect of MARS treatment.

关键词： chronic severe hepatitis end-stage liver disease molecular adsorbents recirculating system

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