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Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles(Microtus ochrogaster)

International Journal of Oral Science 2015年第1期7卷 23-26页

作者： Andrew H Jheon Michaela Prochazkova Michael Sherman Devanand S Manoli Nirao M Shah Lawrence Carbone Ophir Klein Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology University of California San Francisco (UCSF) Department of Anthropology and Human Genetics Faculty of Science Charles University in Prague Laboratory Animal Resource Center UCSF Department of Psychiatry UCSF Department of Anatomy UCSF

Continuously growing incisors are common to all rodents, which include the Microtus genus of voles. However, unlike many rodents, voles also possess continuously growing molars. Here, we report spontaneous molar defects in a population of Prairie voles （Microtus ochrogaster）. We identified bilateral protuberances on the ventral surface of the mandible in several voles in our colony. In some cases, the protuberances broke through the cortical bone. The mandibular molars became exposed and infected, and the maxillary molars entered the cranial vault. Visualisation upon soft tissue removal and microcomputed tomography （microCT） analyses confirmed that the protuberances were caused by the overgrowth of the apical ends of the molar teeth. We speculate that the unrestricted growth of the molars was due to the misregulation of the molar dental stem cell niche. Further study of this molar phenotype may yield additional insight into stem cell regulation and the evolution and development of continuously growing teeth.

关键词： continuously growing teeth molar phenotype mutation stem cell regulation voles

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