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Advanced nerve regeneration enabled by neural conformal electronic stimulators enhancing mitochondrial transport

Bioactive Materials 2024年第9期39卷 287-301页

作者： Hao Bai Siqi Zhang Huiran Yang Jing Wang Hongli Chen Jia Li Lin Li Qian Yang Bo Peng Ziyi Zhu Siyuan Ni Keyin Liu Wei Lei Tiger H.Tao Yafei Feng Department of Orthopedics Xijing HospitalThe Fourth Military Medical UniversityXi’an710032China State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai200050China Key Laboratory of Aerospace Medicine of the Ministry of Education School of Aerospace MedicineFourth Military Medical UniversityXi’anChina The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen361005FujianChina Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an710072PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China School of Physical Science and Technology ShanghaiTech UniversityShanghai200031China Institute of Brain-Intelligence Technology Zhangjiang LaboratoryShanghai200031China

Addressing peripheral nerve defects remains a significant challenge in regenerative *** as the gold-standard management,however,are hindered by limited availability and potential *** recent studies report the potential of wireless electronic system for nerve defects ***,few has met clinical needs for inadequate electrode precision,poor nerve entrapment andinsufficient bioactivity of the matrix ***,we present an advanced wireless electrical nerve stimulator,based on water-responsive self-curling silk membrane with excellent bioabsorbable and *** constructed a unique bilayer structure with an oriented pre-stretched inner layer and a generalsilk membrane as outer *** wetting,the simultaneous contraction of inner layer and expansion of outerlayer achieved controllable super-contraction from 2D flat surface to 3D structural *** enablesshape-adaptive wrapping to cover around nerves,overcomes the technical obstacle of preparing electrodes on theinner wall of the conduit,and prevents electrode breakage caused by material expansion in *** use of forkcapacitor-like metal interface increases the contact points between the metal and the regenerating nerve,solvingthe challenge of inefficient and rough electrical stimulation methods in the *** developed electronicstimulator is effective in restoring 10 mm rat sciatic nerve defects comparable to autologous *** underlyingmechanism involves that electric stimulation enhances anterograde mitochondrial transport to matchenergy *** newly introduced device thereby demonstrated the potential as a viable and efficaciousalternative to autografts for enhancing peripheral nerve repair and functional recovery.

关键词： Silk materials Electronic stimulator Structural reconfiguration Peripheral nerve regeneration mitochondrial transport

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Microfluidic devices as model platforms of CNS injury-ischemia to study axonal regeneration by regulating mitochondrial transport and bioenergetic metabolism

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Cell Regeneration 2022年第1期11卷 337-347页

作者： Ning Huang Zu-Hang Sheng Synaptic Function Section The Porter Neuroscience Research CenterNational Institute of Neurological Disorders and StrokeNational Institutes of HealthRoom 2B-21535 Convent DriveBethesdaMD 20892-3706USA Department of Physiology and Pathophysiology School of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’an 710061ShaanxiChina Institute of Neuroscience Translational Medicine InstituteXi’an Jiaotong University Health Science CenterXi’an 710061ShaanxiChina

Central nervous system(CNS)neurons typically fail to regenerate their axons after injury leading to neurological *** regeneration is a highly energy-demanding cellular program that requires local mitochondria to supply most energy within injured *** emerging lines of evidence have started to reveal that injury-triggered acute mitochondrial damage and local energy crisis contribute to the intrinsic energetic restriction that accounts for axon regeneration failure in the *** and reprogramming bioenergetic signaling and mitochondrial maintenance after axon injury-ischemia is fundamental for developing therapeutic strategies that can restore local energy metabolism and thus facilitate axon ***,establishing reliable and reproduc-ible neuronal model platforms is critical for assessing axonal energetic metabolism and regeneration capacity after *** this focused methodology article,we discuss recent advances in applying cutting-edge microflu-idic chamber devices in combination with state-of-the-art live-neuron imaging tools to monitor axonal regeneration,mitochondrial transport,bioenergetic metabolism,and local protein synthesis in response to injury-ischemic stress in mature CNS neurons.

关键词： Microfluidic device Axon injury Ischemia Axon regeneration mitochondrial transport Axonal bioenergetics Axonal protein synthesis

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A new method for quantifying mitochondrial axonal transport

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Protein & Cell 2016年第11期7卷 804-819页

作者： Mengmeng Chen Yang Li Mengxue Yang Xiaoping Chen Yemeng Chen Fan Yang Sheng Lu Shengyu Yao Timothy Zhou Jianghong Liu Li Zhu Sidan Du Jane Y. Wu University of Chinese Academy of Sciences Beijing 100049 China School of Electronic Science & Engineering Nanjing University Nanjing 210093 China State Key Laboratory for Brain & Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Department of Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School of Medicine Chicago IL 60611 USA

Axonal transport of mitochondria is critical for neuronal survival and function. Automatically quantifying and analyzing mitochondrial movement in a large quantity remain challenging. Here, we report an efficient method for imaging and quantifying axonal mitochondrial trans- port using microfluidic-chamber-cultured neurons together with a newly developed analysis package named ＂MitoQuant＂. This tool-kit consists of an automated program for tracking mitochondrial movement inside live neuronal axons and a transient-velocity analysis program for analyzing dynamic movement patterns of mitochondria. Using this method, we examined axonal mitochondrial movement both in cultured mammalian neurons and in motor neuron axons of Drosophila in vivo. In 3 different paradigms （temperature changes, drug treatment and genetic manipulation） that affect mitochondria, we have shown that this new method is highly efficient and sensitive for detecting changes in mitochondrial movement. The method significantly enhanced our ability to quantitatively analyze axonal mitochondrial movement and allowed us to detect dynamic changes in axonal mltochondrial transport that were not detected by traditional kymographic analyses.

关键词： mitochondrial transport image processing and analysis FUS proteinopathy and mitochondrial transport defect

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Latest assessment methods for mitochondrial homeostasis in cognitive diseases

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Neural Regeneration Research 2024年第4期19卷 754-768页

作者： Wei You Yue Li Kaixi Liu Xinning Mi Yitong Li Xiangyang Guo Zhengqian Li Department of Anesthesiology Peking University Third Hospital Peking University Third Clinical Medical College Beijing Center of Quality Control and Improvement on Clinical Anesthesia Anesthesia and Perioperative Medicine Branch of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

Mitochondria play an essential role in neural function,such as supporting normal energy metabolism,regulating reactive oxygen species,buffering physiological calcium loads,and maintaining the balance of morphology,subcellular distribution,and overall health through mitochondrial *** the recent technological advances in the assessment of mitochondrial structure and functions,mitochondrial dysfunction has been regarded as the early and key pathophysiological mechanism of cognitive disorders such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,mild cognitive impairment,and postoperative cognitive *** review will focus on the recent advances in mitochondrial medicine and research methodology in the field of cognitive sciences,from the perspectives of energy metabolism,oxidative stress,calcium homeostasis,and mitochondrial dynamics(including fission-fusion,transport,and mitophagy).

关键词： cognitive disorders mitochondrial dysfunction mitochondrial energy metabolism mitochondrial dynamics mitochondrial transport mitophagy mitochondrial biogenesis oxidative stress calcium homeostasis

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