Advanced nerve regeneration enabled by neural conformal electronic stimulators enhancing mitochondrial transport

作     者：Hao Bai Siqi Zhang Huiran Yang Jing Wang Hongli Chen Jia Li Lin Li Qian Yang Bo Peng Ziyi Zhu Siyuan Ni Keyin Liu Wei Lei Tiger H.Tao Yafei Feng 

作者机构：Department of OrthopedicsXijing HospitalThe Fourth Military Medical UniversityXi’an710032China State Key Laboratory of Transducer TechnologyShanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai200050China Key Laboratory of Aerospace Medicine of the Ministry of EducationSchool of Aerospace MedicineFourth Military Medical UniversityXi’anChina The Institute of Flexible Electronics(IFEFuture Technologies)Xiamen UniversityXiamen361005FujianChina Frontiers Science Center for Flexible ElectronicsXi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an710072PR China Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing100049China School of Physical Science and TechnologyShanghaiTech UniversityShanghai200031China Institute of Brain-Intelligence TechnologyZhangjiang LaboratoryShanghai200031China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2024年第39卷第9期

页      面：287-301页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(82172476 82172393) 

主　　题：Silk materials Electronic stimulator Structural reconfiguration Peripheral nerve regeneration Mitochondrial transport 

摘      要：Addressing peripheral nerve defects remains a significant challenge in regenerative *** as the gold-standard management,however,are hindered by limited availability and potential *** recent studies report the potential of wireless electronic system for nerve defects ***,few has met clinical needs for inadequate electrode precision,poor nerve entrapment andinsufficient bioactivity of the matrix ***,we present an advanced wireless electrical nerve stimulator,based on water-responsive self-curling silk membrane with excellent bioabsorbable and *** constructed a unique bilayer structure with an oriented pre-stretched inner layer and a generalsilk membrane as outer *** wetting,the simultaneous contraction of inner layer and expansion of outerlayer achieved controllable super-contraction from 2D flat surface to 3D structural *** enablesshape-adaptive wrapping to cover around nerves,overcomes the technical obstacle of preparing electrodes on theinner wall of the conduit,and prevents electrode breakage caused by material expansion in *** use of forkcapacitor-like metal interface increases the contact points between the metal and the regenerating nerve,solvingthe challenge of inefficient and rough electrical stimulation methods in the *** developed electronicstimulator is effective in restoring 10 mm rat sciatic nerve defects comparable to autologous *** underlyingmechanism involves that electric stimulation enhances anterograde mitochondrial transport to matchenergy *** newly introduced device thereby demonstrated the potential as a viable and efficaciousalternative to autografts for enhancing peripheral nerve repair and functional recovery.