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mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity

Bioactive Materials 2021年第12期6卷 4491-4505页

作者： Bibin G.Anand Qi Wu Govindarajan Karthivashan Kiran P.Shejale Sara Amidian Holger Wille Satyabrata Kar Departments of Medicine and University of Alberta EdmontonAlbertaT6G 2M8Canada Centre for Prions and Protein Folding Diseases University of AlbertaEdmontonAlbertaT6G 2M8Canada Department of Metallurgical Engineering and Materials Science Indian Institute of Technology BombayPowaiIndia Departments of Biochemistry University of AlbertaEdmontonAlbertaT6G 2M8Canada

Evidence suggests that increased level/aggregation of beta-amyloid(Aβ)peptides initiate neurodegeneration and subsequent development of Alzheimer’s disease(AD).At present,there is no effective treatment for *** this study,we reported the effects of gold nanoparticles surface-functionalized with a plant-based amino acid mimosine(Mimo-AuNPs),which is found to cross the blood-brain barrier,on the Aβfibrillization process and *** T kinetic assays,fluorescence imaging and electron microscopy data showed that Mimo-AuNPs were able to suppress the spontaneous and seed-induced A_(1-42) *** studies,molecular docking and biochemical analyses further revealed that Mimo-AuNPs stabilize A_(1-42) to remain in its monomeric state by interacting with the hydrophobic domain of A_(1-42)(i.e.,Lys16 to Ala21)there by preventing a conformational shift towards theβ-sheet ***,Mimo-AuNPs were found to trigger the disassembly of matured A_(1-42) fibers and increased neuronal viability by reducing phosphorylation of tau protein and the production of ***,these results reveal that the surface-functionalization of gold nanoparticles with mimosine can attenuate Aβfibrillization and neuronal ***,we propose Mimo-AuNPs may be used as a potential treatment strategy towards AD-related pathologies.

关键词： Alzheimer’s disease β-amyloid aggregation Gold nanoparticles mimosine Neuroprotection

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Direct competition Between mimosine and deoxythymidine triphosphate at the site of DNA replication

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Chinese Science Bulletin 1999年第18期44卷 1669-1672页

作者： Li Liu Shuhui Wang Chinese Acad Med Sci Inst Basic Med Sci Mol Virol Lab Beijing 100005 Peoples R China Peking Union Med Coll Beijing 100005 Peoples R China

mimosine, a plant amino acid, is a reversible cell cycle inhibitor. Biochemical studies have indicated that mimosine may act at multiple levels near the Gl/S interface. By using mi-croinjection technique, it is shown that mimosine can also inhibit the replication of Xenopus ribo-some DNA (rDNA) plasmid reversibly. The high structure similarity between mimosine

关键词： mimosine rDNA DNA replication thymine.

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Isolation of mimosine Degrading Bacteria from Rumen Juice and Mass Production by Gottingen Bioreactor Technology

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Journal of Agricultural Science and Technology(A) 2011年第5期1卷 764-772页

作者： A. Aung U. ter Meulen F. Gessler H. Bohnel Institute of Applied Biotechnology in the Tropics Georg-August-University Gottingen 37079 Germany Department of Physiology and Biochemistry University of Veterinary Science Yezin Myanmar Institute of AnimaI Breeding and Genetics Georg-August-University Gottingen 37075 Germany

A method is described to isolate mfinosine degrading bacteria from mmen juice from German steers which had never been ted on either leucaena or mimosine. The isolate was cultivated in continuous culture in a bench top fermenter in Medium 98-5 amended with an increasing amount of mimosine for 16 days. Degradation of mimosine was determined with a colorrinetfic method Incubated at 39 ℃ under anaerobic conditions, the isolate showed complete degradation of mimosine within one ~veek. The bacteriological pure isolate is an aero-tolerant gram-negative cocco-bacillus. By DNA sequencing analysis it belongs to genus Klebsiella. It was multiplied hi brain-heart-infusion, entrapped in alginate, and dried （37 ℃）. Feeding trials in sheep in Myalmlar showed complete innocuity＇ and complete detoxification of mimosine from leucaena leaves.

关键词： Leucaena mimosine Klebsiella runninants toxicity.

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A sensitive, rapid and validated liquid chromatography ? tandem mass spectrometry (LC-MS-MS) method for determination of mimosine in Mimosa pudica Linn

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Natural Science 2010年第7期2卷 713-717页

作者： Parikshit A. Champanerkar Vikas V. Vaidya Sunita Shailajan Sasikumar N. Menon 不详

A rapid, sensitive and accurate liquid chroma-tographic tandem mass spectrometric method is described for the determination of mimosine in Mimosa pudica Linn. whole plant powder. Mi-mosine was extracted from the plant using 1.0% HCl in water. The chromatographic separation was achieved using a Thermo Hypurity C18 (50 x 4.6 mm) 5.0 μ column interfaced with a triple quadrapole mass spectrometer. The mobile phase consisted of a mixture of Methanol: 10 mM ammonium formate buffer whose pH was ad-justed to 3.00 ± 0.05 with formic acid (80:20, v/v) and was delivered at a flow rate of 1.0 mL min-1. Electrospray ionization (ESI) source operated in the negative ion mode was used for the quantitation. Detection was performed using an Applied Biosystems Sciex API 3200 Mass spec-trometer. The method was found to be simple, precise, accurate, fast, specific and sensitive and can be used for routine quality control analysis of mimosine in Mimosa pudica Linn.

关键词： LC-MS-MS mimosine Mimosa pudica Linn

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Evaluation of hypoxia inducible factor targeting pharmacological drugs as antileishmanial agents

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 633-638页

作者： Marina Dal’Bo Pelegrini Juliana Biar Pereira Solange dos Santos Costa Myriam Janeth Salazar Terreros Adriana Degrossoli Selma Giorgio Department of Animal Biology Biology InstituteUniversidade Estadual de CampinasCampinasSao PauloBrazil

Objective:To evaluate whether hypoxia inducible factor(HIF-1α) targeting pharmacological drugs,echinomycin,resveratrol and CdCl_2 which inhibit HIF-1α stimulation,and mimosine,which enhances the stability of HIF-1α present antileishmanial ***:The leishmanicidal effect of drugs was evaluated in mouse macrophages and Balb/c mouse model for cutaneous ***:Resveratrol and CdCl_2 reduced the parasite load [IC50,(27.3±2.25) μM and(24.8±0.95) μM,respectively].The IC50 value of echinomycin was(22.7±7.36) nM and mimosine did not alter the parasite load in primary *** macrophage viability IC50 values for resveratrol,echinomycin and CdCl_2 and mimosine were >40 μM,>100 nM,> 200 μM and>2 000 μM,*** vivo no differences between cutaneous lesions from control,resveratrol-and echinomycin-treated Balb/c mice were ***:Resveratrol,echinomycin and CdCl_2 reduce parasite survival in *** HIF-1α targeting pharmacological drugs require further study to more fully determine their anti-Leishmania potential and their role in therapeutic strategies.

关键词： Leishmaniosis Hypoxia inducible factor Resveratrol Echinomycin CdCl2 mimosine

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