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A Resource for Inactivation of MicroRNAs Using Short Tandem Target mimic Technology in Model and Crop Plants

Molecular Plant 2018年第11期11卷 1400-1417页

作者： Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang Collaborative Innovation Center of Henan Grain Crops Henan Agricultural UniversityZhengzhou 450002China College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China Department of Kinesiology and Integrative Physiology Life Science and Technology institutedMichigan Technological UniversityHoughtonMI 49931USA School of Technology Michigan Technological UniversityHoughtonMI 49931USA Guangdong Provincial Key Laboratory for Plant Epigenetics College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060P.R.China Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry UniversityBeijing 100083P.R.China Key Laboratory of Plant Stress Biology State Key Laboratory of Cotton BiologySchool of Life SciencesHenan UniversityKaifeng 475004China Department of Biotechnology Sharda UniversityGreater Noida201306India Key Laboratory of Rice Biology in Henan Province Henan Agricultural UniversityZhengzhou 450002China Department of Biological Sciences Ufe Science and Technology InstituteMichigan Technological UniversityHoughtonMI 49931USA Department of Botany and Plant Sciences Institute of Integrative Genome BiologyUniversity of CaliforniaRiversideCA 92521USA School of Forest Resources and Environmental Science Life Science and Technology InstituteMichigan Technological UniversityHoughtonMI 49931USA Department of Computer Science Michigan Technological UniversityHoughtonMI 49931USA Anhui Province Key Laboratory of Medical Physics and Technology Center of Medical Physics and TechnologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhuiChina Hefei Cancer Hospital Chinese Academy of SciencesHefeiAnhuiChina Guangzhou Institute of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina

microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene *** previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in ***,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of *** not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and ***-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA *** facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (https://***/***) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants.

关键词： short tandem target mimic (STTM) miRNA RNA-seq Arabidopsis crop

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Engineering Pathogen Resistance by miRNA Target mimic

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Molecular Plant 2019年第3期12卷 296-297页

作者： Feijie Wu Xiaofeng Cui Molecular Plant

MicroRNAs (miRNAs) are a class of 20- to 24-nt noncoding RNAs that function as important regulators of plant development and stress responses. Most 21-nt miRNAs direct the cleavage of complementary target mRNAs or inhibit their translation, while some 22-nt miRNAs not only cleave target mRNAs but also trigger the bioge nesis of sec on dary small in terfering RNAs (siRNAs) to further repress target mRNAs.

关键词： Engineering Pathogen Resistance miRNA Target mimic

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SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic

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Protein & Cell 2024年第2期15卷 79-82页

作者： Ping Liu Junjie Hui Lei Wang National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China

Disruption of epigenetic regulation in host cells is a common evasion strategy used by viruses(Ozturkler and Kalkan 2021).Recently,Kee et al.(2022)reported that accessory protein ORF8 of SARS-CoV-2 can diffuse into the cell nucleus and mimic histone H3 through the ARKS motif,thereby interfering with H3 post-translational modifications(PTMs),disrupting gene transcription,and diminishing the antiviral response.

关键词： mimic thereby function

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A KINETIC STUDY ON DISMUTATION OF SUPEROXIDE ANION BY A NOVEL SUPEROXIDE DISMUTASE mimic BIS(DIOXOTETRAAMINE) COPPER(Ⅱ) COMPLEX USING PULSE RADIOLYSIS

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南京大学学报(自然科学) 1999年第5期 627-630页

作者： Wang Zhilin 1) Luo Qinhui 1) Zhang Wen 1) Feng Changjian 1) Wang Houwen 2) Zhao Minghua 2) (1)Coordination Chemistry Institute and State Key Laboratory of Coordination Chemistry,Nanjing University,210093, Nanjing,PRC

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Scientific workflow execution system based on mimic defense in the cloud environment

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Frontiers of Information Technology & Electronic Engineering 2018年第12期19卷 1522-1536页

作者： Ya-wen WANG Jiang-xing WU Yun-fei GUO Hong-chao HU Wen-yan LIU Guo-zhen CHENG National Digital Switching System Engineering Technology Research Center

With more large-scale scientific computing tasks being delivered to cloud computing platforms, cloud workflow systems are designed for managing and arranging these complicated tasks. However, multi-tenant coexistence service mode of cloud computing brings serious security risks, which will threaten the normal execution of cloud workflows. To strengthen the security of cloud workflows, a mimic cloud computing task execution system for scientific workflows is proposed. The idea of mimic defense contains mainly three aspects: heterogeneity, redundancy, and dynamics. For heterogeneity, the diversities of physical servers, hypervisors, and operating systems are integrated to build a robust system framework. For redundancy, each sub-task of the workflow will be executed simultaneously by multiple executors. Considering efficiency and security, a delayed decision mechanism is proposed to check the results of task execution. For dynamics, a dynamic task scheduling mechanism is devised for switching workflow execution environment and shortening the life cycle of executors, which can confuse the adversaries and purify task executors. Experimental results show that the proposed system can effectively strengthen the security of cloud workflow execution.

关键词： Scientific workflow mimic defense Cloud security Intrusion tolerance

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Pancreatic and peri-pancreatic lesions mimic pancreatic islet cell tumor in multidetector computed tomography

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Chinese Medical Journal 2011年第11期124卷 1720-1725页

作者： XUE Hua-dan LIU Wei XIAO Yu SUN Hao WANG Xuan LEI Jing JIN Zheng-yu Departmentor RadiologyPeking Union Medical College Hospital Beijing 100730 China

Objective This pictorial review aimed to summarize the most possible differential diagnosis of pancreatic islet cell tumor （PICT）. Data sources Data used in this review were mainly from Medline and Pubmed in English. And all clinical images in this review were from Department of Radiology, Peking Union Medical College Hospital, Beijing, China. Study selection Cases of pancreatic cystadenoma, solid pseudo-papillary tumor of the pancreas, pancreatic metastasis, pancreatic adenocarcinoma, para-pancreatic neuroendocrine tumors, Castleman disease, gastrointestinal stromal tumor, splenic artery aneurysm and accessory spleen were selected in this pictorial review for differential diagnosis of PICT.

关键词： computed tomography islet cell tumor differential diagnosis pancreas mimic

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病原菌培养阴性脓毒症患者的临床特征及死亡风险因素分析——一项基于mimic-Ⅳ数据库资料的单中心回顾性队列研究

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中华危重病急救医学 2021年第10期33卷 1181-1186页

作者：欧啟添蔡耿鑫周媛温妙云广东省人民医院(广东省医学科学院)重症医学科广州510080 华南理工大学医学院广东广州510006 南方医科大学第二临床医学院广东广州510515

目的对比病原菌培养阳性脓毒症(CPS)与培养阴性脓毒症(CNS)患者的特征和结局,以了解培养阴性对预后的影响,并探讨其可能的死亡风险因素。方法采用回顾性队列研究方法,以从美国重症监护医学信息数据库Ⅳv0.4(mimic-Ⅳv0.4)中筛选出的脓... 详细信息

目的对比病原菌培养阳性脓毒症(CPS)与培养阴性脓毒症(CNS)患者的特征和结局,以了解培养阴性对预后的影响,并探讨其可能的死亡风险因素。方法采用回顾性队列研究方法,以从美国重症监护医学信息数据库Ⅳv0.4(mimic-Ⅳv0.4)中筛选出的脓毒症患者作为研究对象。根据确诊脓毒症前后24 h内病原菌培养结果将患者分为CPS组和CNS组,比较两组患者的一般资料、病情资料及医疗操作等。在3个回归模型下,应用Logistic回归法分析CNS与住院病死率的关系。利用卡方分析及中介效应分析探讨初始抗菌药物治疗和90 d内抗菌药物使用史对CNS患者住院病死率的影响。结果共8587例脓毒症患者纳入最终分析,其中CPS组5483例,CNS组3104例。与CPS组相比,CNS组患者年龄更小〔岁:68(56,79)比70(58,81)〕,序贯器官衰竭评分(SOFA)及入重症监护病房(ICU)24 h内进行机械通气、肾脏替代治疗和使用血管升压素比例更高〔SOFA评分(分):3(2,5)比3(2,4),机械通气:48.61%(1509/3104)比39.25%(2152/5483),肾脏替代治疗:13.69%(425/3104)比9.68%(531/5483),血管升压素:15.79%(490/3104)比13.44%(737/5483)〕,且ICU住院时间更长〔d:5(3,10)比3(2,6)〕,住院病死率更高〔25.00%(776/3104)比18.53%(1016/5483)〕,差异均有统计学意义(均P<0.01);但两组在性别分布、入ICU类型、简化急性生理学评分Ⅱ(SAPSⅡ)、查尔森合并症指数(CCI)评分等方面差异均无统计学意义。经过多种因素校正后,CNS是患者院内死亡的危险因素〔优势比(OR)=1.441,95%可信区间(95%CI)为1.273~1.630,P<0.001〕。卡方分析及中介效应分析结果显示,初始抗菌药物治疗对CNS患者住院病死率升高没有显著影响,而90 d内抗菌药物使用史是CNS患者院内死亡的危险因素(OR=1.683,95%CI为1.328~2.134,P<0.05),CNS在90 d内抗菌药物使用史及院内死亡中的中介效应显著(Z=5.302,P<0.001),中介效应占比为7.58%。结论CNS患者较CPS患者病情更重,预后更差。既往90 d内使用过抗菌药物可能与CNS患者住院病死率升高有关,但并不能完全解释CNS高病死率的原因。

关键词：脓毒症病原菌培养阴性住院病死率 mimic

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微波和毫米波单片集成电路（mimic）计划的追溯

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微波学报 2013年第2期29卷 I0049-I0060页

作者：艾略特·科恩 president of EBCO Technology Advising Inc. 11312 Freas Drive North Potomac MD 20878 USA.

自美国国防部（DoD）微波和毫水波单片集成电路（microwave and millimeter—wave monolithic integrated circuits—mimic）计划开始至今，已经过去了四分之一个世纪。

关键词：毫米波单片集成电路 mimic 微波 integrated 美国国防部 wave DoD

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mimic开始用于作战武器系统

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飞航导弹 1990年第9期 35-35,34页

作者：牛晓燕

根据国防部微波和毫米波单片集成电路(mimic)计划开发的新型大功率微型电路已开始用于作战武器系统。首先是用在德克萨斯仪器公司为空军和海军生产的高述反辐射导弹(HARM)上。由于砷化镓(GaAs)mimic芯片的电子迁移率是硅芯片的5倍,因而... 详细信息

根据国防部微波和毫米波单片集成电路(mimic)计划开发的新型大功率微型电路已开始用于作战武器系统。首先是用在德克萨斯仪器公司为空军和海军生产的高述反辐射导弹(HARM)上。由于砷化镓(GaAs)mimic芯片的电子迁移率是硅芯片的5倍,因而其性能更佳。但这并不是国防部竭力倡导将该技术用于下一代电子战、需达、通信和灵巧武器系统的原因,主要是因为采用GaAs mimic可降低设备成本。用mimic芯片代替HARM导引头放大器后,单位成本降低一半(原为3500美元),并可望进一步降至800美元。由于这只是对现有系统的改装,所以改进性能并非目的,尽管这也提高了可靠性。德克萨斯仪器公司于1989年3月开始将mimic芯片用于导弹。

关键词：武器系统集成电路 mimic 芯片

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Atypical Cutaneous Lymphoproliferative Disorder: A Fatal mimic of Cutaneous T-Cell Lymphoma in a Patient with HIV Infection

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World Journal of AIDS 2013年第1期3卷 10-15页

作者： Veronica Nguyen Russell Dorer David M. Aboulafia Albany Medical College Albany USA Division of Hematology and Oncology Virginia Mason Medical Center Seattle USA Division of Hematology University of Washington Seattle USA. Division of Pathology Virginia Mason Medical Center Seattle USA

Atypical cutaneous lymphoproliferative disorder (ACLD) is a rare condition that has been associated with HIV infection. Patients with ACLD present with diffuse, erythematous and pruritic skin lesions accompanied by generalized lymphadenopathy. The clinical characteristics of ACLD overlap most notably with several other conditions including Mycosis Fungoides/Sézary Syndrome (MF/SS), a cutaneous lymphoma of T-cell lineage. Unlike Mycosis Fungoides, the noxious infiltrates of ACLD are not monoclonal but polyclonal and consist of cytotoxic CD8+ T-cells instead of CD4+ T-cells or B-cells. Highly active antiretroviral therapy (HAART) has been reported to improve ACLD. We describe the case of a Caucasian man with longstanding HIV infection who presented with severe erythroderma. Skin and lymph node biopsies showed polyclonal CD8+ T-cell infiltrates. Gene rearrangement studies did not reveal an obvious clonal disorder. Hallmark peripheral blood findings consisting of a severe depletion of CD4+ T-lymphocytes and markedly elevated CD8+ cells provided an important diagnostic clue. Despite the purported benefits of HAART in ameliorating this disorder, erythroderma and extreme pruritus improved only after the patient began taking mycophenolate mofetil and hydroxyurea. Unfortunately, he succumbed to complications of methicillin-resistant Staphylococcus aureus septicemia. We alert readers to this rare HIV-associated condition which may mimic other benign and malignant skin conditions and briefly discuss diagnostic and therapeutic options.

关键词： Atypical Cutaneous Lymphoproliferative Disorder mimic Fatal Cutaneous T-Cell Lymphoma HIV Infection

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