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Exploring the Novel Genetic Variant of PITX1 Gene and Its Effect on milk performance in Dairy Goats

Journal of Integrative Agriculture 2013年第1期12卷 118-126页

作者： LAN Xian-yong ZHAO Hai-yu LI Zhuan-jian ZHOU Rui PAN Chuan-ying LEI Chu-zhao CHEN Hong College of Animal Science and Technology Northwest A&F University/Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Life Sciences Northwest A&F University

Paired-like homeodomain transcription factor 1 （PITX1） plays an important role in pituitary development by indirectly regulating the expression of the GH and PRL genes, and therefore PITX1 gene is regarded as a potential candidate gene for building the relationship between the gene polymorphism and milk traits. The aim of this study was to explore the novel genetic variant in PITX1 gene and its effect on milk performance in dairy goats. Herein, a novel genetic variation （NW_00314033： g.201GA or IVS1＋41GA） located at nt41 position of the first intron of the goat PITX1 gene was reported at the P1 locus, which can be genotyped by the Msp I PCR-RFLP. In the Msp I PCR-RFLP analyis, the GG variant was a major genotype, and the A variant was a minor allele in Guanzhong dairy goats which was at Hardy-Weinberg disequilibrium （chi-square χ2=140, P0.01）. The establishment of associations between different genotypes and milk performance was performed in the analyzed population. A total of three significant associations of the polymorphism with average milk fat content （%）（P=0.045）, morning milk fat content （%）（P=0.049）, and afternoon milk fat content （%）（P=0.050）, were found, respectively. A significant relationship between the polymorphism and average total solid content （P=0.029） was also detected. This novel single nucleotide polymorphism （SNP） extended the spectrum of genetic variation of the goat PITX1 gene, and its significant association with milk performance would benefit from the application of DNA markers related to improving milk performance through marker-assisted selection （MAS） in dairy goats.

关键词： dairy goat PITX1 gene genetic variant association milk performance

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Effects of supplementation of green tea extract on the milk performance of peripartal dairy cows and the expression of stress response genes in the liver

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Journal of Animal Science and Biotechnology 2020年第4期11卷 1163-1174页

作者： Denise K.Gessner Corinna Brock Lena M.Hof Erika Most Christian Koch Klaus Eder Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenHeinrich-Buff-Ring 26-3235392 GiessenGermany Educational and Research Centre for Animal Husbandry Hofgut Neumühle67728 Münchweiler an der AlsenzGermany.

Background: We hypothesised that supplementation of green tea extract(GTE) in dairy cows during the transition period can attenuate proinflammatory conditions and prevent endoplasmic reticulum(ER) stress in the liver of these cows. Thirty Holstein cows with an average parity of 3.06(± 1.31, SD) were divided into a control group and a group that received a daily amount of 10 g of GTE from d 7 before the calving day and a daily amount of 20 g of GTE from the day of calving until d 7 of ***: Cows supplemented with GTE did not show differences in energy intake or milk yield in weeks 2–7 of lactation. However, these cows had a lower milk fat concentration and a lower energy corrected milk yield than the control cows and showed a trend of improved energy balance. The relative m RNA concentrations of proinflammatory genes, genes involved in the acute phase reaction and antioxidant genes in the liver in weeks 1, 4 and 7 of lactation were not different between the two groups of cows. The concentrations of α-tocopherol and the Trolox equivalent antioxidant capacity in plasma were not different between the two groups. However, the group supplemented with GTE showed significant reductions of some genes of the unfolded protein response(UPR) in week 1 and a trend of lower liver triacylglycerol(TAG) concentrations in the liver compared to the control ***: This study shows that supplementation of GTE in dairy cows lowers the fat concentration in the milk but overall has no effect on the expression of inflammatory genes and the antioxidative status in dairy cows during early lactation. The finding of reduced m RNA levels of genes involved in the UPR at week 1, however, supports other results showing that supplementation of polyphenols could prevent the development of ER stress in the liver of cows during early lactation. The finding of a tendency towards a reduced TAG concentration in the liver of cows supplemented with GTE might be due to an improved ene

关键词： Animal nutrition Cow Green tea extract Liver Metabolism milk performance

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Correlation between the Insertion/Deletion Mutations of Prion Protein Gene and BSE Susceptibility and milk performance in Dairy Cows

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国际感染病学（电子版） 2013年第4期2卷 153-162页

作者： Shen-rong Hu Yong-tao Huai Chuan-ying Pan Chu-zhao Lei Hong Chen Xian-yong Lan College of Animal Science and Technology Northwest A&F UniversityShaanxi Key Laboratory of Molecular Biology for Agriculture

Objective To investigate the 23 bp and 12 bp insertion/deletion(indel)mutations within the bovine prion protein(PRNP)gene in Chinese dairy cows,and to detect the associations of two indel mutations with BSE susceptibility and milk *** Based on bovine PRNP gene sequence,two pairs of primers for testing the 23 bp and 12 bp indel mutations were *** PCR amplification and agarose electrophoresis were carried out to distinguish the different genotypes within the ***,based on previous data from other cattle breeds and present genotypic and allelic frequencies of two indels mutations in this study,the corrections between the two indel mutations and BSE susceptibility were tested,as well as the relationships between the mutations and milk performance traits were analyzed in this study based on the statistical *** In the analyzed Chinese Holstein population,the frequencies of two"del"alleles in 23 bp and 12 bp indel muations were more *** frequency of haplotype of 23del-12del was higher than those of 23del-12ins and *** the estimated r2and D’values,two indel polymorphisms were linked strongly in the Holstein population(D’=57.5%,r2=0.257).Compared with the BSE-affected cattle populations from the reported data,the significant differences of genotypic and allelic frequencies were found among present Holstein and some BSE-affected populations(Pmilk performance and resistant mastitis traits were analyzed in Holstein population,but no significant differences were found(P>0.05).Conclusions These observations revealed that the influence of two indel mutations within the bovine PRNP gene on BSE depended on the breed and they

关键词： Dairy cows Prion protein(PRNP) gene Bovine spongiform encephalopathy(BSE) Insertion/deletion(indel) mutation Association milk performance

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Effects of Supplementary Feed with Different Apple Pomace-to-Alfalfa Meal Ratios on milk performance of Dairy Cows

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Animal Husbandry and Feed Science 2010年第2期2卷 20-22页

作者： SUN Pan-feng GAO Teng-yun Henan Vocational College of Agriculture Zhengzhou 451450 China Henan Agricultural University Zhengzhou 450002 China

[Objective] To study the effects of apple pomace on milk performance of dairy cows. ~Method] A total of 48 Holstein dairy cows at the same parity and with close lactation stage and similar daily milk yield were randomly assigned to six groups. The supplementary feed was composed of apple pomace, alfalfa meal, com and premix, and it was processed into pellets. In the groups I - V, the percentage of apple pomace was 17.5%, 35.0%, 52.5%, 70.0% and 0%, respectively. Each cow was fed with supplementary feed （3 kg/d）. [ Result] The milk yield in the group II and group V was increased significantly （ P 〈 0.05）, and the fat content in milk of the group III and V was significantly higher than that of the con- trol group （P 〈 0.05）. [ Conclusion] The supplementary apple pomace can improve the milk performance of dairy cows effectively.

关键词： Apple pomace Supplementary feed Dairy cows milk performance

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milk selenium content and speciation in response to supranutritional selenium yeast supplementation in cows

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Animal Nutrition 2021年第4期7卷 1087-1094页

作者： Lingling Sun Gentao Liu Dongmei Xu Zhaohai Wu Lu Ma Sanz-Fernandez M.Victoria Lance H.Baumgard Dengpan Bu State Key Laboratory of Animal Nutrition Institute of Animal Sciences of Chinese Academy of Agricultural SciencesBeijing 100193China Comparative Physiology Group Subdireccion General de Investigacion y Tecnologia(SGIT)Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA)Madrid 28040Spain Department of Animal Science Iowa State UniversityAmes 50014USA CAAS-ICRAF Joint Lab on Agroforestry and Sustainable Animal Husbandry Beijing 100193China Hunan Co-Innovation Center of Animal Production Safety CICAPSChangshaHunan 410128China

The effects of selenium(Se)yeast supplementation on performance,blood biochemical and antioxidant parameters,and milk Se content and speciation were ***-six mid-lactation Holstein dairy cows were randomly assigned to 1 of 3 treatments:1)control(basal diet containing Se at 0.11 mg/kg DM),2)basal diet+0.5 mg supplemental Se/kg DM(SY-0.5),and 3)basal diet+5 mg supplemental Se/kg DM(SY-5).Selenium was supplemented as Se *** trial consisted of a 1-week pretrial period and an 8-week experimental *** somatic cell score decreased with SY-5 supplementation(Pperformance parameters were not affected(P>0.05).The serum Se concentration increased with the increasing levels of Se yeast supplementation(Pmilk total Se concentration increased with Se dose(Pmilk with increased Se species including selenomethionine and *** results can provide useful information on milk Se species when a high dose Se yeast was supplemented in the cow diet.

关键词： Dairy cow Selenium yeast Selenium speciation milk performance

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