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Influence of Intravesical Lower pH on the micturition Reflex Threshold in the Rat

Open Journal of Urology 2014年第12期4卷 143-150页

作者： Peng Zeng Shaohua Zeng Chonghe Jiang Janwen Zeng Jianfeng Mo Sivert Lindströ m Department of Urology Qingyan City People’s Hospital of Jinan University Guangdong China Department of Clinical and Experimental Medicine University of Link&ouml ping Link&ouml ping Sweden

Aims: To investigate whether intravesical lower pH induces a micturition threshold reflex change of anaesthetized rats. Methods: Thirteen female rats, anaesthetized by a-chloralose and paralyzed by pancurone bromide were used for the experiments. The micturition threshold volume was determined by repeated cystometry. Simultaneously bladder afferent activities in four and efferent activities in seven rats were recorded from the exposed pelvic nerve to the bladder. Results: Cystometry with acidic saline at pH 3 and 4 induced a significant decrease in micturition threshold volume. The mean value of these groups of test showed that bladder compliance, micturition threshold pressure and maximal micturition contraction pressure were decreased significantly comparing with the controls. There were no changes in all other parameters recorded from afferent and efferent, e.g. afferent threshold volume, afferent or efferent activity at the micturition threshold and their peak activity at the micturition contraction. Conclusions: Acidic solution provoked sensitivity but reduced the force of the contractility to the urinary bladder. The effect was presented without a detectable change in the firing properties of bladder Ad mechanoreceptor afferents. It is proposed that proton sensitive bladder receptors with unmyelinated afferent were stimulated by the acidic solution and that the micturition reflex was facilitated by afferent inflow from such receptors. The findings were clinically important in choosing the medium for urodynamic examination.

关键词： pH Urinary Bladder micturition Threshold Volume Afferent Efferent Rat

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Refex seizures induced by micturition: a case report

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Acta Epileptologica 2023年第1期6卷 43-51页

作者： Zhiyun Zhang Qiwei Li Tiejia Jiang Jiajia Fang Department of Neurology The Fourth Afliated HospitalInternational Institutes of MedicineZhejiang University School of MedicineYiwu 322000China Department of Neurology The Children’s Hospital of Zhejiang University School of MedicineHangzhou 310009China

Background Refex seizures(RS)induced by micturition are extremely rare,and the clinical and electroencephalogram features of RS are not widely known among *** particular,the origin of the epileptic area is still *** presentation An 8-year-old girl who had generalized tonic-clonic seizures was diagnosed with RS induced by micturition based on the clinical manifestation and EEG *** also reviewed the clinical and EEG characteristics of RS induced by micturition in literature by searching the databases of PubMed and MEDLINE using keywords“micturition refex seizure”,“refex seizure induced by micturition”,and“micturition induced seizure”by January *** speculate that the mechanism of micturition-induced RS may involve excessive neuronal excitation in regions that participate in *** The RS in this patient was considered to be induced by *** should be raised to this rare form of RS among practitioners.

关键词： Refex seizure micturition Scalp electroencephalogram Ictogenesis Case report

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Fluoxetine,a selective serotonin reuptake inhibitor used clinically,improves bladder function in a mouse model of moderate spinal cord injury

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Neural Regeneration Research 2021年第10期16卷 2093-2098页

作者： Long Ma Jing-Yuan Tang Jin-Yong Zhou Chen Zhu Xin Zhang Ping Zhou Qiu Yu Yan Wang Xiao-Jian Gu Department of Urology Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsu ProvinceChina Department of Central Laboratory Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsu ProvinceChina

After spinal cord injury,the upward conduction of the spinal cord is lost,resulting in the loss of micturition control,which manifests as detrusor sphincter dyssynergia and insufficient *** have shown that serotonergic axons play important roles in the control of the descending urination *** this study,mouse models of moderate spinal cord contusions were *** serotonin agonists quipazine(0.2 mg/kg),8-hydroxy-2-(di-n-propylamino)tetralin(8-OH-DAPT,0.1 mg/kg),buspirone(1 mg/kg),sumatriptan(1 mg/kg),and rizatriptan(50 mg/kg),the serotonin reuptake inhibitors fluoxetine(20 mg/kg)and duloxetine(1 mg/kg),and the dopamine receptor agonist SKF-82197(0.1 mg/kg)were intraperitoneally administered to the model mice 35 days post-injury in an acute *** voided stain on paper method and urodynamics revealed that fluoxetine reduced the amount of residual urine in the bladder and decreased bladder and external urethral sphincter pressure in a mouse model of moderate spinal cord ***,fluoxetine did not improve the micturition function in a mouse model of severe spinal cord *** contrast,the other serotonergic drugs had no effects on the micturition functions of spinal cord injury model *** study was ethically approved by the Institutional Animal Care and Use Committee of Jiangsu Province Hospital of Chinese Medicine(approval No.2020DW-20-02)on September 11,2020.

关键词： bladder external urethral sphincter fluoxetine micturition selective serotonin reuptake inhibitor spinal cord injury urodynamics voided stain on paper measurement

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Are prostatic calculi independent predictive factors of lower urinary tract symptoms？

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Asian Journal of Andrology 2010年第2期12卷 221-226页

作者： Sung-Woo Park Jong-Kil Nam Sang-Don Lee Moon-Kee Chung Medical Research Institute and Department of Urology Pusan National University Yangsan Hospital Yangsan 626-770Korea

We determined the correlation between prostatic calculi and lower urinary tract symptoms （LUTS）,as well as the predisposing factors of prostatic calculi. Of the 1 527 patients who presented at our clinic for LUTS,802underwent complete evaluations,including transrectal ultrasonography,voided bladder-3 specimen and international prostatic symptoms score （IPSS）. A total of 335 patients with prostatic calculi and 467 patients without prostatic calculi were divided into calculi and no calculi groups,respectively. Predictive factors of severe LUTS and prostatic calculi were determined using uni/multivariate analysis. The overall IPSS score was 15.7±9.2 and 14.1±9.1 in the calculi and no calculi group,respectively （P = 0.013）. The maximum flow rate was 12.1±6.9 and 14.2±8.2 mL s^（-1） in the calculi and no calculi group,respectively （P = 0.003）. On univariate analysis for predicting factors of severe LUTS,differences on age （P = 0.042）,prostatic calculi （P = 0.048） and prostatitis （P = 0.018） were statistically significant. However,on multivariate analysis,no factor was significant. On multivariate analysis for predisposing factors of prostatic calculi,differences on age （P〈0.001） and prostate volume （P = 0.001） were significant. To our knowledge,patients who have prostatic calculi complain of more severe LUTS. However,prostatic calculi are not an independent predictive factor of severe LUTS. Therefore,men with prostatic calculi have more severe LUTS not only because of prostatic calculi but also because of age and other factors. In addition,old age and large prostate volume are independent predisposing factors for prostatic calculi.

关键词： micturition prostate prostatic diseases

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Roles of dopaminergic receptors in bladder and erectile function at the spinal level

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Asian Journal of Andrology 2002年第4期4卷 287-290页

作者： Osamu Ishizuka Hiroya Mizusawa Osamu Nishizawa Department of Urology Shinshu University School of Medicine 3-1-1 Asahi Matsumoto 390-8621 JapanDepartment of Urology Shinshu University School of Medicine 3-1-1 Asahi Matsumoto 390-8621 JapanDepartment of Urology Shinshu University School of Medicine 3-1-1 Asahi Matsumoto 390-8621 Japan

1 Introduction At the spinal level, the dopaminergic, the α1adrenergic and the neurokinin receptors play definite roles in the micturition control. From the anatomical point of view, the spinal center of micturition is located close to the center of erectile function. Recently, apomorphine is used for the treatment of erectile dysfunction and its mechanism of action is considered to be mainly through the central nervous system. 2 Dopaminergic receptors and bladder function at the spinal level

关键词： apomorphine penile erection micturition spinal cord

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New pharmacological approaches against chronic bowel and bladder problems in paralytics

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World Journal of Critical Care Medicine 2016年第1期5卷 1-6页

作者： Pierre A Guertin Department of Psychiatry and Neurosciences Laval University Laval University Medical Center (CHU de Québec - CHUL)

Spinal cord injury(SCI) leads generally to an irreversible loss of sensory functions and voluntary motor control below injury level. Cures that could repair SCI and/or restore voluntary walking have not been yet developed nor commercialized. Beyond the well-known loss of walking capabilities, most SCI patients experience also a plethora of motor problems and health concerns including specific bladder and bowel dysfunctions. Indeed, chronic constipation and urinary retention, two significant life-threatening complications, are typically found in patients suffering of traumatic(e.g., falls or car accidents) or non-traumatic SCI(e.g., multiple sclerosis, spinal tumors). Secondary health concerns associated with these dysfunctions include hemorrhoids, abdominal distention, altered visceral sensitivity, hydronephrosis, kidney failure, urinary tract infections, sepsis and, in some cases, cardiac arrest. Consequently, individuals with chronic SCI are forced to regularly seek emergency and critical care treatments when some of these conditions occur or become intolerable. Increasing evidence supports the existence of a novel experimental approach that may be capable of preventing the occurrence or severity of bladder and bowel problems. Indeed, recent findings in animal models of SCI have revealed that, despite paraplegia or tetraplegia, it remains possible to elicit episodes of micturition and defecation by acting pharmacologically or electrically upon specialized lumbosacral neuronal networks, namely the spinal or sacral micturition center(SMC) and lumbosacral defecation center(LDC). Daily activation of SMC and LDC neurons could potentially become, new classes of minimally invasive treatments(i.e., if orally active) against these dysfunctions and their many lifethreatening complications.

关键词： Prevention of intensive care problems Quality of care Temporary recovery of vital functions micturition Defecation Spinal networks Central pattern generators

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Bacterial Urinary Tract Infections among Males with Lower Urinary Tract Obstruction at Komfo Anokye Teaching Hos-pital, Kumasi, Ghana

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Open Journal of Urology 2012年第3期2卷 131-136页

作者： Christian Kofi Gyasi-Sarpong Edwin Mwintiereh Ta-ang Yenli Ali Idriss Addae Appiah Arhin Ken Aboah Roland Azorliade Yaw Agyekum Boaitey Augustina Angelina Annan Data Management Department Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR) Kumasi Ghana Department of Surgery (Urology Unit) Komfo Anokye Teaching Hospital Kumasi Ghana Microbiology Department (Agogo) Kumasi Centre for Collaborative Research in Tropical Medicine Kumasi Ghana Microbiology Department Komfo Anokye Teaching Hospital (KATH) Kumasi Ghana

Purpose: We describe the commonest pathology responsible for lower urinary tract obstruction (LUTO) and associated symptoms such as UTI, etc. among males at the Komfo Anokye Teaching Hospital (KATH) in Kumasi. Materials and Methods: Between January and December 2009, prospective cross sectional hospital based study was conducted involving 103 subjects. Patients with symptoms of LUTO and who were on short admission (up to 48 hours) at the accident and emergency unit of KATH were identified as potential study subjects. All the patients presented with acute retention of urine at the emergency unit of KATH and urethral catheterization was attempted to relieve them of the retention under sterile conditions. Those patients whose initial catheterization failed went through suprapubic cystostomy (suprapubic catheterization). Urine specimens for culture and sensitivity tests were then collected into sterile urine containers immediately after the catheterization (irrespective of type). Ultrasound Scan was requested for all the patients to assist in diagnosing enlargement of the prostate and other associated urological pathologies. Retrograde urethrogram was however, requested for those patients with suprapubic catheterization and which helped in the diagnosis of the urethral stricture. For a particular child, urethral catheter was passed under sterile condition and Micturicting Cysto-Urethrogram (MCUG) was done to assist in diagnosing posterior urethral valve and other conditions. Those subjects whose urinalysis revealed pyuria and positive urine culture and who had voluntarily agreed to enter the study were enrolled. Subjects whose urine culture had multiple bacteria growth that was deemed to be contaminants were excluded from the study. Results: The mean age for males with LUTO was 62 years. The youngest male with LUTO was aged 2 years whilst the maximum age was 93 years. LUTO due to prostatic hyperplasia was found in 79 (76.7%) men;23 (22.3%) had LUTO due to urethral stric

关键词： Hyperplasia Prostatic Dysuria micturition Nocturia Suprapubic Haematuria Nephelometer Asymptomatic Bacteriuria Acute Cystitis Prostatitis Pyelonephritis Osteomyelitis Urosepsis Cystoscopy Catheter Benign Stricture

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New avenues for reducing intensive care needs in patients with chronic spinal cord injury

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World Journal of Critical Care Medicine 2016年第4期5卷 201-203页

作者： Pierre A Guertin Department of Psychiatry and Neurosciences Laval University Laval University Medical Center (CHU de Québec - CHUL)

Relatively soon after their accident, patients suffering a spinal cord injury(SCI) begin generally experiencing the development of significant, often life-threatening secondary complications. Many of which are associated with chronic physical inactivity-related immune function problems and increasing susceptibility to infection that repeatedly requires intensive care treatment. Therapies capable of repairing the spinal cord or restoring ambulation would normally prevent many of these problems but, as of now, there is no cure for SCI. Thus, management strategies and antibiotics remain the standard of care although antimicrobial resistance constitutes a significant challenge for patients with chronic SCI facing recurrent infections of the urinary tract and respiratory systems. Identifying alternative therapies capable of safe and potent actions upon these serious health concerns should therefore be considered a priority. This editorial presents some of the novel approaches currently in development for the prevention of specific infections after SCI. Among them, brain-permeable small molecule therapeutics acting centrally on spinal cord circuits that can augment respiratory capabilities or bladder functions. If eventually approved by regulatory authorities, some of these new avenues may potentially become clinically-relevant therapies capable of indirectly preventing the occurrence and/or severity of these lifethreatening complications in people with paraplegic or tetraplegic injuries.

关键词： Prevention of intensive care problems Quality of care Temporary recovery of vital functions micturition Spinal networks Central pattern generators

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