Fluoxetine,a selective serotonin reuptake inhibitor used clinically,improves bladder function in a mouse model of moderate spinal cord injury

作     者：Long Ma Jing-Yuan Tang Jin-Yong Zhou Chen Zhu Xin Zhang Ping Zhou Qiu Yu Yan Wang Xiao-Jian Gu Long Ma;Jing-Yuan Tang;Jin-Yong Zhou;Chen Zhu;Xin Zhang;Ping Zhou;Qiu Yu;Yan Wang;Xiao-Jian Gu

作者机构：Department of UrologyJiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsu ProvinceChina Department of Central LaboratoryJiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsu ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第10期

页      面：2093-2098页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：This work was supported by Jiangsu Province Hospital of Chinese Medicine No.Y19061(to LM) 

主　　题：bladder external urethral sphincter fluoxetine micturition selective serotonin reuptake inhibitor spinal cord injury urodynamics voided stain on paper measurement 

摘      要：After spinal cord injury,the upward conduction of the spinal cord is lost,resulting in the loss of micturition control,which manifests as detrusor sphincter dyssynergia and insufficient *** have shown that serotonergic axons play important roles in the control of the descending urination *** this study,mouse models of moderate spinal cord contusions were *** serotonin agonists quipazine(0.2 mg/kg),8-hydroxy-2-(di-n-propylamino)tetralin(8-OH-DAPT,0.1 mg/kg),buspirone(1 mg/kg),sumatriptan(1 mg/kg),and rizatriptan(50 mg/kg),the serotonin reuptake inhibitors fluoxetine(20 mg/kg)and duloxetine(1 mg/kg),and the dopamine receptor agonist SKF-82197(0.1 mg/kg)were intraperitoneally administered to the model mice 35 days post-injury in an acute *** voided stain on paper method and urodynamics revealed that fluoxetine reduced the amount of residual urine in the bladder and decreased bladder and external urethral sphincter pressure in a mouse model of moderate spinal cord ***,fluoxetine did not improve the micturition function in a mouse model of severe spinal cord *** contrast,the other serotonergic drugs had no effects on the micturition functions of spinal cord injury model *** study was ethically approved by the Institutional Animal Care and Use Committee of Jiangsu Province Hospital of Chinese Medicine(approval No.2020DW-20-02)on September 11,2020.