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Pharmacological interventions targeting the microcirculation following traumatic spinal cord injury

Neural Regeneration Research 2024年第1期19卷 35-42页

作者： Rongrong Wang Jinzhu Bai Department of Spine and Spinal Cord Surgery Beijing Bo’ai HospitalChina Rehabilitation Research CenterBeijingChina School of Rehabilitation Medicine Capital Medical UniversityBeijingChina

Traumatic spinal cord injury is a devastating disorder chara cterized by sensory,motor,and autonomic dysfunction that seve rely compromises an individual's ability to perform activities of daily *** adve rse outcomes are closely related to the complex mechanism of spinal cord injury,the limited regenerative capacity of central neurons,and the inhibitory environment fo rmed by traumatic *** to the microcirculation is an important pathophysiological mechanism of spinal cord injury.A number of therapeutic agents have been shown to improve the injury environment,mitigate secondary damage,and/or promote regeneration and *** them,the spinal cord microcirculation has become an important target for the treatment of spinal cord *** inte rventions targeting the microcirculation can improve the microenvironment and promote recovery following spinal cord *** drugs target the structure and function of the spinal cord microcirculation and are essential for maintaining the normal function of spinal neuro ns,axons,and glial *** review discusses the pathophysiological role of spinal cord microcirculation in spinal cord injury,including its structure and histopathological ***,it summarizes the progress of drug therapies targeting the spinal cord mic rocirc ulation after spinal cord injury.

关键词： blood-spinal cord barrier drug therapy microcirculation microvascular blood flow neuroprotection pharmacological intervention pharmacotherapy spinal cord injury trauma

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Effect of resistance exercise on insulin sensitivity of skeletal muscle

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World Journal of Meta-Analysis 2021年第2期9卷 101-107页

作者： Bo Wang Xu Luo Rong-Rong Li Ya-Na Li Yu-Chi Zhao Department of Internal Medicine Yantaishan HospitalYantai 264001Shandong ProvinceChina Department of Pathophysiology School of Basic MedicineBinzhou Medical UniversityYantai 264003Shandong ProvinceChina Department of Osteoarthropathy Yantaishan HospitalYantai 264001Shandong ProvinceChina

Insulin resistance(IR)is the common pathophysiological basis of many metabolic *** is characterized by decreased glucose uptake in skeletal muscle and adipose tissue,especially in skeletal *** muscle is the main target tissue of glucose uptake under insulin *** uptake by skeletal muscle is complex,and it is controlled by many *** PI3K/AKt/GSK-1 signaling pathway is not only the main pathway for insulin signal transduction but also an important mechanism for regulating blood *** the binding of insulin to its receptors on the surface of target cells to the transportation of glucose from extracellular fluid to skeletal muscle,a series of signal transduction processes is completed,any of which potentially affects the physiological effects of insulin and leads to *** exercise(RT)can reduce skeletal muscle IR and effectively improve blood glucose control and glycosylated hemoglobin level in patients with type 2 diabetes mellitus(T2DM).However,the exact mechanism by which RT improves skeletal muscle IR remains ***,this paper discusses the above problems by tracking the progress of the literature to deepen the correlation between RT and skeletal muscle insulin sensitivity and provide further evidence for the application of exercise therapy in *** conclusion,RT mainly improves insulin sensitivity of skeletal muscle by increasing muscle mass,microvascular blood flow,and glucose transporter-4 expression in skeletal muscle,as well as by reducing lipid accumulation and inflammation in skeletal ***,it is potentially useful in the prevention and treatment of T2DM.

关键词： Resistance exercise Insulin sensitivity Insulin resistance Skeletal muscle microvascular blood flow Muscle mass

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