Pharmacological interventions targeting the microcirculation following traumatic spinal cord injury

作     者：Rongrong Wang Jinzhu Bai Rongrong Wang;Jinzhu Bai

作者机构：Department of Spine and Spinal Cord SurgeryBeijing Bo’ai HospitalChina Rehabilitation Research CenterBeijingChina School of Rehabilitation MedicineCapital Medical UniversityBeijingChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第1期

页      面：35-42页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by Key Project of China Rehabilitation Research Center Nos.2022ZX-05 2018ZX-08(both to JB) 

主　　题：blood-spinal cord barrier drug therapy microcirculation microvascular blood flow neuroprotection pharmacological intervention pharmacotherapy spinal cord injury trauma 

摘      要：Traumatic spinal cord injury is a devastating disorder chara cterized by sensory,motor,and autonomic dysfunction that seve rely compromises an individual s ability to perform activities of daily *** adve rse outcomes are closely related to the complex mechanism of spinal cord injury,the limited regenerative capacity of central neurons,and the inhibitory environment fo rmed by traumatic *** to the microcirculation is an important pathophysiological mechanism of spinal cord injury.A number of therapeutic agents have been shown to improve the injury environment,mitigate secondary damage,and/or promote regeneration and *** them,the spinal cord microcirculation has become an important target for the treatment of spinal cord *** inte rventions targeting the microcirculation can improve the microenvironment and promote recovery following spinal cord *** drugs target the structure and function of the spinal cord microcirculation and are essential for maintaining the normal function of spinal neuro ns,axons,and glial *** review discusses the pathophysiological role of spinal cord microcirculation in spinal cord injury,including its structure and histopathological ***,it summarizes the progress of drug therapies targeting the spinal cord mic rocirc ulation after spinal cord injury.