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A single nucleotide mutation in the dual-oxidase 2(DUOX2) gene causes some of the panda's unique metabolic phenotypes

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National Science Review 2022年第2期9卷 34-42页

作者： Agata M.Rudolf Qi Wu Li Li Jun Wang Yi Huang Jacques Togo Christopher Liechti Min Li Chaoqun Niu Yonggang Nie Fuwen Wei John R.Speakman State Key Laboratory of Molecular Development Institute of Genetics and Developmental Biology Chinese Academy of Sciences Institute of Zoology Chinese Academy of Sciences Institute of Microbiology Chinese Academy of Sciences Institute of Biological and Environmental Sciences University of Aberdeen Centre of Excellence for Animal Ecology and Genetics Chinese Academy of Sciences Shenzhen Key Laboratory of Metabolic Health Center for Energy Metabolism and Reproduction Shenzhen Institute of Advanced Technology Chinese Academy of Sciences

The giant panda(Ailuropoda melanoleuca) is an iconic bear native to China,famous for eating almost exclusively *** unusual dietary behavior for a carnivore is enabled by several key adaptations including low physical activity,reduced organ sizes and hypothyroidism leading to lowered energy *** adaptive phenotypes have been hypothesized to arise from a panda-unique single-nucleotide mutation in the dual-oxidase 2(DUOX2) gene,involved in thyroid hormone *** test this hypothesis,we created genome-edited mice carrying the same point mutation as the panda and investigated its effect on metabolic *** mice were 27% smaller than heterozygous and wild-type ones,had 13 % lower body mass-adjusted food intake,5 5 % decreased physical activity,lower mass of kidneys(11%) and brain(5%),lower serum thyroxine(T4:36%),decreased absolute(12%) and mass-adjusted(5%) daily energy expenditure,and altered gut *** with T4 reversed the effects of the *** work uses a state-of-the-art genome editing approach to demonstrate the link between a single-nucleotide mutation in a key endocrine-related gene and profound adaptive changes in the metabolic phenotype,with great importance in ecology and evolution.

关键词： giant panda DUOX2 mutation metabolic rate thyroid hormones DUOX2 mice and microbiota

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