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Journal of Analysis and Testing 2024年第2期8卷 191-200页

作者： Siamak Kiani Shahvandi Mehrorang Ghaedi Hamid Ahmar Chemistry Department Yasouj UniversityYasouj75918-74831Iran Chemistry Department University of ZabolZabol98615-538Iran

In this work,a new liquid-phase microextraction method coupled with an electrochemical technique using a switchable solvent was proposed for the determination of *** extraction solvent used was dipropylamine(DPA),which exhibited switchable *** means that it can become miscible or immiscible when in contact with carboxylic acids in the aqueous *** metronidazole was then measured using a glassy carbon electrode that was modified with Au-multiwalled carbon nanotubes(MWCNTs).The eff ect of diff erent parameters such as the type and amount of trigger,the addition of salt,and the volume of extraction solvent on the e fficiency of switchable hydrophilic solvent-based liquid-phase microextraction(SHS-LPME)was investigated using the one-factor-at-a-time *** optimizing the conditions,the linear calibration curve was obtained in the concentration range of 0.005–250μmol/***,the limit of quantification(LOQ)of 0.005μmol/L and the limit of detection(LOD)of 0.0015μmol/L were obtained,respectively.

关键词： Switchable solvent metronidazole Liquid-phase microextraction Electrochemical techniques

Physicochemical and in Vitro Antibacterial Evaluation of metronidazole Loaded Eudragit S‑100 Nanofbrous Mats for the Intestinal Drug Delivery

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Advanced Fiber Materials 2022年第1期4卷 76-88页

作者： Priyanka Prakash Rade Prabhanjan Shridhar Giram Ajinkya A.Shitole Neeti Sharma Baijayantimala Garnaik Polymer Science and Engineering Division CSIR-National Chemical LaboratoryPune 411008India Academy of Scientifc and Innovative Research(AcSIR) Ghaziabad 201002India Symbiosis School of Biological Sciences Symbiosis International(Deemed University)Pune 412115India

metronidazole(MTZ)loaded Eudragit S-100(ES-100)nonwoven nanofbrous mats were successfully electrospun and evaluated for intestinal drug *** was varied in the range of 1–15%(w/w)in ES-100 nanofbrous mats,the morphological characterization of nanofbrous mats was carried out using FE-SEM and the average diameter of nanofber was found in the range 150–600 *** and DSC demonstrated the amorphous nature of MTZ in ES-100 nanofbrous *** contact angle analysis confrmed the hydrophobic *** mechanical strength of ES-100 nanofbrous mats decreased with increasing MTZ *** drug release profles showed 74%MTZ release from ES-100d within 2 h at pH 6.8 which is the colonic *** activities against gram-positive bacteria(Staphylococcus aureus)and gramnegative bacteria(Escherichia coli)showed that the ES-100 nanofbrous mats loaded with MTZ exhibited good activity.

关键词： ES-100 metronidazole Nanofbers Antibacterial Intestinal drug delivery

A sensitive electrochemical detection of metronidazole in synthetic serum and urine samples using low-cost screen-printed electrodes modified with reduced graphene oxide and C60

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Journal of Pharmaceutical Analysis 2021年第5期11卷 646-652页

作者： Elsa Maria Materon Ademar Wong Tayane Aguiar Freitas Ronaldo Censi Faria Osvaldo N.Oliveira Jr. Department of Chemistry Federal University of Sao Carlos13560-970Sao CarlosBrazil Sao Carlos Institute of Physics University of Sao Paulo13560-970Sao CarlosBrazil

Monitoring the concentration of antibiotics in body fluids is essential to optimizing the therapy and minimizing the risk of bacteria resistance,which can be made with electrochemical sensors tailored with appropriate *** this paper,we report on sensors made with screen-printed electrodes(SPE)coated with fullerene(C60),reduced graphene oxide(rGO)and Nafion(NF)(C60-rGO-NF/SPE)to determine the antibiotic metronidazole(MTZ).Under optimized conditions,the C60-rGO-NF/SPE sensor exhibited a linear response in square wave voltammetry for MTZ concentrations from 2.5×10^(-7) to 34×10^(-6) mol/L,with a detection limit of 2.1×10^(-7) mol/*** sensor was also capable of detecting MTZ in serum and urine,with recovery between 94%and 100%,which are similar to those of the standard chromatographic method(HPLC-UV).Because the C60-rGO-NF/SPE sensor is amenable to mass production and allows for MTZ determination with simple principles of detection,it fulfills the requirements of therapeutic drug monitoring programs.

关键词： metronidazole Fullerene Reduced graphene oxide Screen-printed electrodes Antibiotic

Supramolecular Assemblies of Three New metronidazole Derivatives Constructed with Various Dihydroxy-benzoic Acids via Hydrogen Bonds

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Chemical Research in Chinese Universities 2020年第6期36卷 1196-1202页

作者： QU Huiqi PAN Longhai SUN Yuexin WANG Lei LI Yanyan ZHANG Mingjuan ZHANG Zhaoxiang LIN Haifeng Taishan Scholar Advantage and Characteristic Discipline Team of Eco Chemical Process and Technology Key Laboratory of Eco-chemical EngineeringCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042P.R.China

metronidazole(MTZ)is an important antibiotic,which has been widely applied to cure protozoal and bacterial diseases for human beings or ***,three novel drug supramolecular crystals constructed by MTZ with 2.5-dihydroxy-benzoic acid(2.5-DHBA)(1),2.6-dihydroxy-benzoic acid(2.6-DHBA)(2)and 3,5-dihydroxy-benzoic acid(3.5-DHBA)(3),respectively,have been *** hydrogen bonds of N-H…O(O-H…N).C-H…O and O-H…O play important roles in the 3D supramolecular framework formation for crystals *** to the vary locations of the substituent groups,the two-dimensional layers in crystals 1 or 2 are constructed via intermolecular hydrogen bonds between MTZ and 2,5-DHBA or 2.6-DHBA,while in crystal 3 water molecules play a significant role except the intermolecular hydrogen bonds between MTZ and 3,*** addition,five synthons of I R^22(8),ⅡR3(9)in crystal 1,ⅢR1(4),ⅣR2(8)in crystal 2 andⅤR2(7)in crystal 3 formed through various hydrogen bonds are founded in this *** studies of syntheses,crystal structures and thermal analysis are reported.

关键词： metronidazole Supramolecular assembly Hydrogen bond Thermal stability

An Evaluation of metronidazole Degradation in a Plasma-Assisted Rotating Disk Reactor Coupled with TiO2 in Aqueous Solution

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Engineering 2021年第11期7卷 1603-1610页

作者： Yong Cai Guang-Wen Chu Yong Luo Meng-Jun Su Bao-Ju Wang Bao-Chang Sun Jian-Feng Chen State Key Laboratory of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High-Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China

Pollution involving pharmaceutical components in bodies of water is an increasingly serious environmental *** discharge for the degradation of antibiotics is an emerging technology that may be relevant toward addressing this *** this work,a plasma-assisted rotating disk reactor(plasma-RDR)and a photocatalyst—namely,titanium dioxide(TiO_(2))—were coupled for the treatment of metronidazole(MNZ).Discharge uniformity was improved by the use of a rotating electrode in the plasma-RDR,which contributed to the utilization of ultraviolet(UV)light radiation in the presence of TiO_(2).The experimental results showed that the degradation efficiency of MNZ and the concentration of generated hydroxyl radicals respectively increased by 41%and 2.954 mg∙L^(-1) as the rotational speed increased from 0 to 500 r∙min^(-1).The synergistic effect of plasma-RDR plus TiO_(2) on the generation of hydroxyl radicals was *** intermediate products were identified using three-dimensional(3D)excitation emission fluorescence matrices(EEFMs)and liquid chromatography-mass spectrometry(LC-MS),and a possible degradation pathway is proposed *** plasma-catalytic process has bright prospects in the field of antibiotics degradation.

关键词： Plasma-assisted rotating disk reactor Pulsed discharge metronidazole Degradation TiO_(2)

Ultrasensitive electrochemical determination of metronidazole based on polydopamine/carboxylic multi-walled carbon nanotubes nanocomposites modified GCE

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Journal of Pharmaceutical Analysis 2018年第2期8卷 124-130页

作者： Satar Tursynbolat Yrysgul Bakytkarim Jianzhi Huang Lishi Wang School of Chemistry and Chemical Engineering South China University of Technology

An ultrasensitive electrochemical sensor based on polydopamine/carboxylic multi-walled carbon nanotubes(MWCNTs à COOH) nanocomposites modified glassy carbon electrode(GCE) was presented in this work, which has been developed for highly selective and highly sensitive determination of an antimicrobial drug, metronidazole. The preparation of polydopamine/MWCNTs–COOH nanocomposites/GCE sensor is simple and possesses high reproducible, where polydopamine can be coated on the surface of MWCNTs–COOH via a simple electropolymerization process. Under optimized conditions, the proposed sensor showed ultrasensitive determination for metronidazole with a wide linear detection range from5 to 5000 mmol/dm^3 and a low detection limit of 0.25 mmol/dm^3(S/N=3). Moreover, the proposed sensor has been successfully applied for the quantitative determination of metronidazole in real drug samples. This work may provide a novel and effective analytical platform for determination of metronidazole in application of real pharmaceutical and biological samples analysis.

关键词： metronidazole Polydopamine Carboxylic multi-walled carbon nanotubes Nanocomposites Electrochemical determination Electrochemical sensor

Influence of Some Physicochemical Exposure Factors on the metronidazole Content of a Pharmaceutical Product: Flagyl®250 mg Tablet

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Open Journal of Physical Chemistry 2022年第3期12卷 31-45页

作者： Mariette Desiree Yehe Frédérique Yah Marie-Pierre Nikiema Linda Hé Vincent De Paul Ovi Jean-Kisito Kouame Patrick Grah Atheba Gildas Komenan Gbassi Department of Analytical Sciences and Public Health UFR of Pharmaceutical and Biological Sciences (UFR SPB) Félix Houphou&#235 t Boigny University Abidjan Ivory Coast National Public Health Laboratory Food Control Service Abidjan Ivory Coast Félix Houphouë t Boigny University Laboratory of Analytical Chemistry Bromatology General Chemistry and Inorganic Chemistry Abidjan Ivory Coast

The present work aims to study the influence of some physicochemical parameters (light, temperature, ethanol, bile salts, potassium hydroxide, hydrogen peroxide) on the content of metronidazole (MTZ) contained in the reference substance (SR) and in a pharmaceutical specialty Flagyl® 250 mg tablet (FLG). The method developed was linear and accurate in accordance with USP 38 and the MTZ contents were obtained by UV-visible spectrophotometry at 278 nm. These contents ranged from 225 mg to 275 mg and were thus consistent with the concentration present in the proprietary medicines (250 mg). The study of the influence of physicochemical parameters on the MTZ content in SR and FLG showed that MTZ contents are unstable in the presence of Ethanol at 96˚, KOH at 0.1N and bile salts but also when the temperature is higher than 25˚C. However, they remain stable in the presence of light and H2O2 and undergo degradation in an acidic environment.

关键词： metronidazole Influence Physicochemistry Content Stability

Simultaneous determination of metronidazole and tinidazole in plasma by using HPLC-DAD coupled with second-order calibration

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Chinese Chemical Letters 2010年第10期21卷 1223-1226页

作者： Li Qun Ouyang Hai Long Wu Ya Juan Liu Jian Yue Wang Yong Jie Yu Hong Yan Zou Ru Qin Yu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Zhoushan Municipal Center for Disease Control & Prevention Zhoushan 310062 China

A method using HPLC-DAD coupled with second-order calibration was developed to simultaneously determine metronidazole and tinidazole in plasma samples in this paper. The second-order calibration method based on APTLD （alternating penalty trilinear decomposition） algorithm was proposed to analyze the three-way HPLC-DAD data from both standard and prediction samples, which makes it possible that calibration can be performed even in the presence of unknown interferences with a simple and green chromatographic condition and short analysis time. The results showed that good recoveries were obtained although the chromatographic and spectral profiles of the analytes of interest as well as background were partially overlapped with each other in plasma samples.

关键词： HPLC-DAD Second-order calibration Alternating penalty trilinear decomposition (APTLD) metronidazole Tinidazole Plasma

Introducing nitazoxanide as a promising alternative treatment for symptomatic to metronidazole-resistant giardiasis in clinical isolates

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 866-871页

作者： Tahereh Mikaeili Galeh Abdolhassan Kazemi Mahmoud Mahami-Oskouei Behzad Baradaran Adel Spotin Seddigheh Sarafraz Majid Karamat Immunology Research Center Tabriz University of Medical Sciences Department of Parasitology and Mycology Faculty of MedicineTabriz University of Medical Sciences East Azerbaijan Province Health Center Tabriz Health Center

Objective:To identify the frequencies(F) of ferredoxin and nitroreductase mutations were identified on Iranian clinical isolates of Giardia lamblia in order to predict whether the nitazoxanide can be prescribed as suitable drug for symptomatic to metronidazoleresistant ***:Forty Giardia lamblia isolates as of 38 symptomatic and two metronidazole-resistant patients were collected from *** were extracted and amplified by targeting ferredoxin and Gl NR *** amplicons were directly sequenced to determine gene ***:The various amino acid substitutions(F:20%,Haplotype diversity:0.891,Tajima's D:-0.44013) were identified by analyzing ferredoxin gene in four symptomatic and two resistant ***,two haplotypes(F:5%,HD:0.345; Tajima's D:0.77815) characterized in metronidazole-resistant isolates of Gl NR,however,no point mutations was found in symptomatic ***:Non-synonymous mutations of ferredoxin oxidoreductase gene reduce translational regulatory protein's binding affinity which concludes reduction of ferredoxin expression and its *** leads to decrease in metronidazole drug delivery into the *** in these isolates may lead to their resistance to *** to low synonymous mutations of Gl NR demonstrates that nitazoxanide can be prescribed as promising alternative treatment for symptomatic to metronidazole-resistant giardiasis in Iranian clinical isolates.

关键词： Giardia lamblia Ferredoxin oxidoreductase Nitroreductase Nitazoxanide metronidazole

Clinical efficacy and safety of moxifloxacin versus levofloxacin plus metronidazole for community-acquired pneumonia with aspiration factors

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Chinese Medical Journal 2014年第7期127卷 1201-1205页

作者： Sun Tieying Sun Li Wang Rongmei Ren Xiaoping Sui Dong-jiang Pu Chun Ren Yajuan Liu Ying Yang Zhuo Li Fengzhi Department of Respiratory and Critical Care Medicine Beijing Hospital of the Ministry of Health Beijing 100730 China Department of Respiratory Diseases Shaanxi Provincial People's Hospital Xi'an Shaanxi 710068China Department of Respiratory Diseases Air Force General HospitalPeople's Liberation Army Beijing 100142 China

Background Community-acquired pneumonia （CAP） is a common infectious disease throughout the world and the incidence continues to grow as the population *** is an important pathogenic mechanism for pneumonia in the elderly and the management of patients with community-acquired pneumonia with aspiration factors is a major medical *** study aimed to assess whether moxifloxacin in comparison to levofloxacin plus metronidazole are effective and safe in the treatment of community-acquired pneumonia with aspiration *** In this prospective,multicenter,open-label,randomized controlled trial,77 patients with mild-to-moderate community-acquired pneumonia with aspiration factors were enrolled and randomly assigned to receive moxifloxacin or levofloxacin plus *** primary efficacy variables were clinical outcomes in evaluable patients at a follow-up visit 7 to 14 days after the end of *** Seven days after the end of therapy a clinical cure was achieved for 76.7％（23 of 37） of efficacy-evaluable patients in the moxifloxacin group and 51.7％（15 of 40） of patients in the levofloxacin plus metronidazole *** was a significant difference between the two groups （x2=4.002,P ＜0.05）.Bacteriological success rates were similar in the moxifloxacin group （93.3％） and levofloxacin plus metronidazole group （96.4％）,there was no significant difference between the two groups （P ＞0.05）.The overall adverse event rate was 10.8％（4/37） in the moxifloxacin group versus 17.5％（7/40） in the levofloxacin plus metronidazole group,there was no significant difference between the two groups （P＞0.05）.No serious adverse events were *** Moxifloxacin is effective and safe for treatment of community-acquired pneumonia with aspiration *** the regimen of moxifloxacin monotherapy is more convenient compared with levofloxacin plus metronidazole.

关键词： pneumonia community-acquired infection moxifloxacin levofloxacin metronidazole