Supramolecular Assemblies of Three New Metronidazole Derivatives Constructed with Various Dihydroxy-benzoic Acids via Hydrogen Bonds

作     者：QU Huiqi PAN Longhai SUN Yuexin WANG Lei LI Yanyan ZHANG Mingjuan ZHANG Zhaoxiang LIN Haifeng QU Huiqi;PAN Longhai;SUN Yuexin;WANG Lei;LI Yanyan;ZHANG Mingjuan;ZHANG Zhaoxiang;LIN Haifeng

作者机构：Taishan Scholar Advantage and Characteristic Discipline Team of Eco Chemical Process and TechnologyKey Laboratory of Eco-chemical EngineeringCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2020年第36卷第6期

页      面：1196-1202页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Supported by the National Natural Science Foundation of China(Nos.21801150,51802170,51772162) the Outstanding Youth Foundation of Shandong Province,China(No.ZR2019J014) the Youth Innovation and Technology Foundation of Shandong Higher Education Institutions,China(No.2019KJC004) the Taishan Scholar Young Talent Program and the Major Scientific and Technological Innovation Project,China(No.2019172Y020405) 

主　　题：Metronidazole Supramolecular assembly Hydrogen bond Thermal stability 

摘      要：Metronidazole(MTZ)is an important antibiotic,which has been widely applied to cure protozoal and bacterial diseases for human beings or ***,three novel drug supramolecular crystals constructed by MTZ with 2.5-dihydroxy-benzoic acid(2.5-DHBA)(1),2.6-dihydroxy-benzoic acid(2.6-DHBA)(2)and 3,5-dihydroxy-benzoic acid(3.5-DHBA)(3),respectively,have been *** hydrogen bonds of N-H…O(O-H…N).C-H…O and O-H…O play important roles in the 3D supramolecular framework formation for crystals *** to the vary locations of the substituent groups,the two-dimensional layers in crystals 1 or 2 are constructed via intermolecular hydrogen bonds between MTZ and 2,5-DHBA or 2.6-DHBA,while in crystal 3 water molecules play a significant role except the intermolecular hydrogen bonds between MTZ and 3,*** addition,five synthons of I R^22(8),ⅡR3(9)in crystal 1,ⅢR1(4),ⅣR2(8)in crystal 2 andⅤR2(7)in crystal 3 formed through various hydrogen bonds are founded in this *** studies of syntheses,crystal structures and thermal analysis are reported.