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Ultrasensitive methyl salicylate gas sensing determined by Pd-doped SnO_(2)

Frontiers of Materials Science 2022年第4期16卷 71-79页

作者： Chaoqi ZHU Xiang LI Xiaoxia WANG Huiyu SU Chaofan MA Xiang GUO Changsheng XIE Dawen ZENG State Key Laboratory of Material Processing and Die&Mould Technology Department of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechnologyXiangyang 441003China

Efficient chemicalwarfare agents(CWAs)detection is required to protect people from the cWAs in war and terrorism.In this work,a Pd-doped SnO_(2)nanoparticles-based gas sensor was developed to detect a nerve agent simulant named methyl salicylate.The sensing measurements of methyl salicylate under different Pd doping amounts found that the 0.5 at.%Pd-doped SnO_(2)exhibited a significant improvement in the detection of methyl salicylate at the ppb(1ppb=10-9)level,and the response value to 160 ppb methyl salicylate is 0.72 at 250℃.Compared with the pure SnO_(2),the response value is increased by 4.5 times,which could be attributed to the influence of the noble metal Pd on the oxygen state and its catalytic effect.In addition,the 0.5at.%Pd-doped SnO_(2)sensor still has an obvious response to 16ppb methyl salicylate with a response value of 0.13,indicating the lower detection limit of the sensor.

关键词： SnO_(2) methyl salicylate gas sensor Pd doping noble metal

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Studies on the Scavenger Activities of Salicylaldehyde and methyl salicylate Against Hydroxyl Radical

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Chemical Research in Chinese Universities 2005年第2期21卷 251-252页

作者： MAJian-hua CollegeofBiologyEngineeringofJimeiUniversity Xiamen361021P.R.China

Active oxygen species have a carcinogenesis effect, and can cause mutation, cardiovascular diseases, inflammation and aging, etc. Hydroxyl radicals generated either from a radiolysis of water contained in biological tissues or from a redox cycling implicated in a wide range chemical toxicants, have been recognized as the extremely reactive oxidative species which can attack DNA bases and sugar moiety of nucleotides and lead to radiation or chemical injury of DNA and other biological targets[1-5].Therefore, In recent years many pharmacologists and biologists are looking for effective free radical scavengers, especially naturally occurring antioxidants of oxidizing free radicals as drugs.

关键词： Salicylaldehyde methyl salicylate Hydroxyl radical Pulse radiolysis

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Efficacy and mechanism of methyl salicylate in the enhancement of skin delivery of herbal medicines

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Journal of Traditional Chinese Medical Sciences 2021年第4期8卷 336-342页

作者： Jingyan Wang Xinyu Zhao Jiajia Chen Xin Li Doudou Hao Tingting Li Kai Mei Yi Lan Qing Wu Department of TCM Pharmaceutics School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China Beijing Children's Hospital Capital Medical UniversityBeijing100045China Pharmaceutical Technology and Development Beijing Fengke Ruitai Pharmaceutical Technology Co.Ltd.Beijing100070China

Objective: To elucidate the molecular mechanism(s) by which methyl salicylate enhances the skin delivery of herbal ingredients with diverse lipophilicity.Methods: The toxicity of methyl salicylate on skin cell lines was evaluated using the MTT assay. The Franz diffusion cell method was used to measure the permeability enhancing activities of methyl salicylate for five herbal ingredients with a range of lipophilicities. The interaction between methyl salicylate and the stratum corneum(SC) was observed by using an infrared spectroscopy technique. Moreover, the solubilities and SC-vehicle partition coefficient were determined to monitor the impact of methyl salicylate on the drug thermodynamic activities and partition into the SC layer, respectively.Results: Compared with azone(1-dodecylazacycloheptan-2-one), methyl salicylate showed lower toxicity to skin cells in terms of the IC50 values. The in vitro skin permeation studies showed that methyl salicylate could greatly improve the cumulative amounts or steady state flux of the selected model drugs with the exception of osthole, which indicated that methyl salicylate was prone to promote the skin delivery of hydrophilic drugs. The Fourier transform infrared spectroscopy studies revealed that methyl salicylate mainly interacted with SC lipids, leading to the disruption of the orderly arrangement of the SC.In addition, methyl salicylate had no obvious effect on the drug thermodynamic activity and partition into the SC.Conclusion: methyl salicylate could effectively promote the skin delivery of relatively hydrophilic ingredients in externally used traditional Chinese medicines(TCM) without obvious cytotoxicity.

关键词： methyl salicylate Transdermal delivery Penetration enhancer Stratum corneum Fourier transform infrared spectroscopy

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Expression and functional characterization of odorant-binding protein 2 in the predatory mite Neoseiulus barkeri

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Insect Science 2023年第5期30卷 1493-1506页

作者： Yixia Wu Yaying Li Wenqiang Chu Tiandi Niu Xiaotian Feng Rongjiang Ma Huai Liu Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityBeibei DistrictChongqing400715 China

Olfaction plays a crucial role for arthropods in foraging,mating,and oviposition.The odorant-binding protein(OBP)gene is considered one of the most important olfactory genes.However,little is known about its functions in predatory mites.Here,we used Neoseiulus barkeri,an important commercialized natural pest control,to explore the chemosensory characteristics of OBP.In this study,N.barkeri was attracted by methyl salicylate(MeSA)and showed higher crawling speeds under MeSA treatment.Then,we identified and cloned an OBP gene named Nbarobp2 and analyzed its expression profiles in the predatory mite.Nbarobp2 was 663 bp,was highly expressed in larval and nymphal stages,and was significantly upregulated in N.barkeri under MeSA treatment.Nbarobp2 encoded 202 amino acid residues with a molecular weight of 23 kDa(after removing the signal peptide).Sequence comparisons revealed that the OBPs in Arachnida shared 6 conserved cysteine sites,but were distinguishable from the OBPs of Insecta on the phylogenetic tree.RNA interference,Western blotting,and binding affinity assays further proved that Nbarobp2 was involved in volatile perception in predatory mites.This study shed light on the functional characteristics of OBPs in predatory mites,providing a new insight for better biological control.

关键词： binding affinity crawling speed heterologous expression methyl salicylate olfactory behavior RNA interference

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