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Distinct hippocampal pathways mediate dissociable roles of context in memory retrieval

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Distinct hippocampal pathways mediate dissociable roles of c...

Effects of immune activation on the retrieval of spatial memory

中国神经科学学会第十二届全国学术会议

作者： Chun Xu Sabine Krabbe Jan Gründemann Paolo Botta Jonathan P.Fadok Fumitaka Osakada Dieter Saur Benjamin F.Grewe Mark J.Schnitzer Edward M.Callaway Andreas Lüthi University of Basel Laboratory of Cellular Pharmacology Nagoya University

Memories about sensory experiences are tightly linked to the context in which they were formed. memory contextualization is fundamental for the selection of appropriate behavioral reactions needed for survival, yet the underlying neuronal circuits are poorly understood. By combining trans-synaptic viral tracing and optogenetic manipulation, we found that the ventral hippocampus（v HC） and the amygdala, two key brain structures encoding context and emotional experiences, interact via multiple parallel pathways. A projection from the v HC to the basal amygdala mediates fear behavior elicited by a conditioned context, whereas a parallel projection from a distinct subset of v HC neurons onto midbrain-projecting neurons in the central amygdala is necessary for context-dependent retrieval of cued fear memories. Our findings demonstrate that two fundamentally distinct roles of context in fear memory retrieval are processed by distinct v HC output pathways, thereby allowing for the formation of robust contextual fear memories while preserving context-dependent behavioral flexibility.

关键词： memory retrieval fear hippocampus amygdala rabies trans-synaptic tracing optogenetics contextual fear fear renewal

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Neuroscience Bulletin 2010年第5期26卷 355-364页

作者：黄振波王皓饶秀茸梁涛许晶蔡祥胜盛国庆中国科学院广州生物医药与健康研究院华南干细胞与再生医学研究所中国科学院再生生物学重点实验室

Objective It has been shown that there are extensive interactions between the central nervous system and the immune *** present study focused on the effects of lipopolysaccharide（LPS）on memory retrieval,to explore the interaction between immune activation and *** C57BL/6J mice（8 weeks old）were first trained in the Morris water maze to reach asymptotic *** mice were tested 24 h after the last training session and LPS was administered（1.25 mg/kg,i.p.）4 h prior to the *** retrieval of spatial memory was tested by probe trial,and the time spent in the target quadrant and the number of platform location crosses were *** was performed to detect interleukin-1β（IL-1β）protein level in the hippocampus of mice tested in the water *** Although LPS induced overt sickness behavior and a significant increase in the level of IL-1β in the hippocampus of mice,there was no significant difference in the time spent in the target quadrant or in the number of platform location crosses between LPS-treated and control groups in the probe trial *** Immune activation induced by LPS does not impair the retrieval of spatial memory.

关键词： lipopolysaccharide immune activation sickness behavior hippocampus interleukin-1β Morris water maze spatial memory memory retrieval

Optogenetics and its application in neural degeneration and regeneration

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Neural Regeneration Research 2017年第8期12卷 1197-1209页

作者： Josue D.Ordaz Wei Wu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Goodman Campbell Brain and Spine IndianapolisIndianaUSA Department of Anatomy and Cell Biology Indiana University School of MedicineIndianapolisINUSA

Neural degeneration and regeneration are important topics in neurological diseases. There are limited options for therapeutic interventions in neurological diseases that provide simultaneous spatial and temporal control of neurons. This drawback increases side effects due to non-specific targeting. Optogenetics is a technology that allows precise spatial and temporal control of cells. Therefore, this technique has high potential as a therapeutic strategy for neurological diseases. Even though the application of optogenetics in understanding brain functional organization and complex behaviour states have been elaborated, reviews of its therapeutic potential especially in neurodegeneration and regeneration are still limited. This short review presents representative work in optogenetics in disease models such as spinal cord injury, multiple sclerosis, epilepsy, Alzheimer＇s disease and Parkinson＇s disease. It is aimed to provide a broader perspective on optogenetic therapeutic potential in neurodegeneration and neural regeneration.

关键词： light-activated proteins neural plasticity spinal cord injury epilepsy Parkinson's disease Alzheimer'sdisease multiple sclerosis neural engineering memory retrieval neuron inhibition neuron activation neuralregeneration

A hippocampus-inspired illumination time-resolved device for neural coding

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Science China Materials 2022年第4期65卷 1087-1093页

作者： Caihong Li Wen Du Hezhuang Liu Mao Yang Hao Xu Jiang Wu Zhiming Wang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu610054China School of Physics University of Electronic Science and Technology of ChinaChengdu610054China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu610054China

Artificial photonic synapses have set off a new upsurge for mimicking a series of neural activities in recent *** particular,the investigation of learning and memory behaviors with pressure or emotion and corresponding mechanisms is currently the focus of more ***,a hippocampus-inspired device based on MoS_(2) for illumination time encoding is fabricated,in which the encryption technology is employed for data *** addition,the pressureinduced memory behaviors with full memory function(memory trace)over time such as encoding,storage and retrieval are demonstrated,resulting from the decreasing positive photocurrent of the MoS;*** proposed mechanism of the memory effect when exposed to the light is elucidated in ***,the effect of stress hormone on memory behavior is displayed via different illumination time periods and light *** results indicate the potential application of MoS_(2) devices in artificial neural network.

关键词： illumination time memory trace pressure-induced memory behavior memory encoding memory retrieval

Balanced dopamine is critical for pattern completion during associative memory recall

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Balanced dopamine is critical for pattern completion during ...