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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Amy YANG Claire Xi ZHANG Department of Physiology University of TorontoTorontoCanada Institute of Molecule Medicine Peking University

＜正＞A fundamental question is whether AP encodes affect total neurotransmitter release in CNS *** a previous study,we showed that action potential（AP） encodes（time organization of APs） can modulate total "presynaptic" secretion in isolated adrenal chromaffin *** Calyx of Held is a large glutamatergic synapse in mammalian auditory brainstem and participates in sound *** secretion on its presynaptic terminal can be recorded by membrane capacitance（Cm） in mouse brainstem ***,we study modulation of evoked secretion by AP encodes in calyx synapses in mouse brain *** stimulus pattern is defined by a AP "code function" F（N,m,f,d） with "N" as number of total APs,"m" as number of AP bursts,"f" as AP frequency,and "d" as interval time between two AP *** results are:（1） F（100,m,100 Hz,0.2 s）-induced presynaptic capacitance was facilitated by 62%at m = 4 vs 1,termed "mfacilitation";（2） The total postsynaptic EPSC-integration,which is proportional to total glutamate release,was facilitated by 33%;（3） The smaller "m-facilitation" measured by post synaptic EPSCs *** capacitance suggests,that the average quantal size of glutamate release from single synaptic vesicle is accompanied with the "m-facilitation" in the CNS synapses,implying that the facilitated release from recycled and late-released vesicles has lower glutamate concentration during a intensive synaptic *** conclude that synaptic transmission is modulated by AP encodes in mouse CNS.

关键词： membrane capacitance brain slice action potential pattern

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Detection of the apoptosis of Jurkat cell using an electrorotation chip

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Frontiers in Biology 2006年第2期1卷 208-212页

作者： Long Quan Xing Wanli Department of Biological Sciences and Biotechnology Tsinghua UniversityBeijing 100084China School of Medicine Tsinghua UniversityBeijing 100084China National Engineering Research Center for Beijing Biochip Technology Beijing 102206China

The apoptosis of cells is one of the fields that attract increasing attention in biology ***,the cells are treated with chemicals when detecting *** is highly desired to detect apoptosis in a real-time *** of Jurkat cells was studied using a real-time electrorotation *** chip allows the detection of the cell membrane capacitance changes during the course of apoptosis and therefore facilitates the analysis of apoptosis in a real-time basis without involving any chemical treatment.

关键词： apoptosis electrorotation chip membrane capacitance

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