检索结果-南通市图书馆

Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Frontiers of Medicine 2022年第3期16卷 416-428页

作者： Jiansong Huang Xin Huang Yang Li Xia Li Jinghan Wang Fenglin Li Xiao Yan Huanping Wang Yungui Wang Xiangjie Lin Jifang Tu Daqiang He Wenle Ye Min Yang Jie Jin Department of Hematology Key Laboratory of Hematologic MalignanciesDiagnosis and TreatmentThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Institute of Hematology Zhejiang University School of MedicineHangzhou 310003China Department of Obstetrics The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hematology Qingdao Municipal HospitalQingdao 266000China Department of Laboratory Medicine Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310003China Cancer Center Zhejiang UniversityHangzhou 310058China

Abivertinib,a third-generation tyrosine kinase inhibitor,is originally designed to target epidermal growth factor receptor(EGFR)-activating *** studies have shown that abivertinib has promising antitumor activity and a well-tolerated safety profile in patients with non-small-cell lung ***,abivertinib also exhibited high inhibitory activity against Bruton’s tyrosine kinase and Janus kinase *** that these kinases play some roles in the progression of megakaryopoiesis,we speculate that abivertinib can affect megakaryocyte(MK)differentiation and platelet *** treated cord blood CD34+hematopoietic stem cells,Meg-01 cells,and C57BL/6 mice with abivertinib and observed megakaryopoiesis to determine the biological effect of abivertinib on MK differentiation and platelet *** in vitro results showed that abivertinib impaired the CFU-MK formation,proliferation of CD34+HSC-derived MK progenitor cells,and differentiation and functions of MKs and inhibited Meg-01-derived MK *** results suggested that megakaryopoiesis was inhibited by *** also demonstrated in vivo that abivertinib decreased the number of MKs in bone marrow and platelet counts in mice,which suggested that thrombopoiesis was also ***,these preclinical data collectively suggested that abivertinib could inhibit MK differentiation and platelet biogenesis and might be an agent for thrombocythemia.

关键词： abivertinib Btk inhibitor platelet megakaryocyte megakaryopoiesis thrombopoiesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Induction of differentiation of human stem cells ex vivo: Toward large-scale platelet production

引用

World Journal of Stem Cells 2019年第9期11卷 666-676页

作者： Xiao-Hua Lei Yi-Qing Yang Chi-Yuan Ma En-Kui Duan State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Faculty of Laboratory Medical Science Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

Platelet transfusion is one of the most reliable strategies to cure patients suffering from thrombocytopenia or platelet *** the increasing demand for transfusion,however,there is an undersupply of donors to provide the platelet ***,scientists have sought to design methods for deriving clinical-scale platelets ex *** there has been considerable success ex vivo in the generation of transformative platelets produced by human stem cells(SCs),the platelet yields achieved using these strategies have not been adequate for clinical *** this review,we provide an overview of the developmental process of megakaryocytes and the production of platelets in vivo and ex vivo,recapitulate the key advances in the production of SC-derived platelets using several SC sources,and discuss some strategies that apply three-dimensional bioreactor devices and biochemical factors synergistically to improve the generation of large-scale platelets for use in future biomedical and clinical settings.

关键词： megakaryopoiesis Platelet production Transfusion Bioreactors Stem cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：