Induction of differentiation of human stem cells ex vivo: Toward large-scale platelet production
Induction of differentiation of human stem cells ex vivo: Toward large-scale platelet production作者机构：State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China Faculty of Laboratory Medical ScienceHebei North UniversityZhangjiakou 075000Hebei ProvinceChina
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2019年第11卷第9期
页 面：666-676页
核心收录：
学科分类：10[医学]
基 金：Supported by the National Natural Science Foundation of China Grants,No.31600683 and No.U1738103 Strategic Priority Research Program of the Chinese Academy of Sciences,No.XDA15014000
主 题：Megakaryopoiesis Platelet production Transfusion Bioreactors Stem cells
摘 要：Platelet transfusion is one of the most reliable strategies to cure patients suffering from thrombocytopenia or platelet *** the increasing demand for transfusion,however,there is an undersupply of donors to provide the platelet ***,scientists have sought to design methods for deriving clinical-scale platelets ex *** there has been considerable success ex vivo in the generation of transformative platelets produced by human stem cells(SCs),the platelet yields achieved using these strategies have not been adequate for clinical *** this review,we provide an overview of the developmental process of megakaryocytes and the production of platelets in vivo and ex vivo,recapitulate the key advances in the production of SC-derived platelets using several SC sources,and discuss some strategies that apply three-dimensional bioreactor devices and biochemical factors synergistically to improve the generation of large-scale platelets for use in future biomedical and clinical settings.
维普期刊数据库