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Journal of Clinical and Nursing Research 2024年第2期8卷 228-233页

作者： Chuanyu Chen Yan Wang Zhen Wang Jing Deng Qi Zhang People’s Hospital of Luhe District in Nanjing Nanjing 211500Jiangsu ProvinceChina

Objective:This study aimed to explore the application and effectiveness of the DRG model in the perioperative management of *** comparing the DRG model with traditional management methods,this study focused on evaluating the potential impact of the DRG model in improving surgical efficiency and reducing complication rates and medical ***:The random envelope method was used to divide patients scheduled for cholecystectomy from January 2021 to October 2023 into two groups:one group underwent surgery under the DRG model(experimental group),and the other group underwent the traditional management model(control group).Data including basic information,surgery-related data,length of stay,complication records,and medical expenses were *** analysis was carried out using a t-test and chi-square(χ2)***:Results showed that the DRG model shortened the average length of stay,decreased the incidence of complications,reduced medical expenses,and increased patient *** results demonstrate the effectiveness of the DRG model in the perioperative management of cholecystectomy,especially in improving surgical efficiency,reducing medical costs,and improving patient ***:The DRG model in the perioperative management of cholecystectomy can significantly improve medical service quality and efficiency and enhance patient satisfaction as compared to traditional treatment methods.

关键词： DRG model Cholecystectomy medical management

medical management of ischemic stuttering priapism： a ：ontemporary review of the literature

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Asian Journal of Andrology 2012年第1期14卷 156-163,180页

作者： Helen R Levey Omer Kutlu Trinity J Bivalacqua The Arthur Smith Institute for Urology North Shore- Long Island Jewish Health System New Hyde Park NY 11010 USA The James Buchanan Brady Urological Institute Department of Urology Johns Hopkins Hospital Baltimore MD 21287 USA

Priapism is defined as a prolonged and persistent erection of the penis without sexual stimulation. This is a poorly understood disease process with little information on the pathophysiology of this erectile disorder. Complications from this disorder are devastating due to the irreversible erectile damage and resultant erectile dysfunction （ED）. Stuttering priapism, though relatively rare, affects a high prevalence of men with sickle-cell disease （SCD） and presents a challenging problem with guidelines for treatment lacking or resulting in permanent ED. The mechanisms involved in the development of priapism in this cohort are poorly characterized; therefore, medical management of priapism represents a therapeutic challenge to urologists. Additional research is warranted, so we can effectively target treatments for these patients with prevention as the goal. This review gives an introduction to stuttering priapism and its clinical significance, specifically with regards to the patient with SCD. Additionally, the proposed mechanisms behind its pathophysiology and a summary of the current and future targets for medical management are discussed.

关键词： erectile dysfunction ischemic priapism medical management recurrent priapism sickle cell disease stuttering priapism therapy treatment

Anorexia nervosa:Outpatient treatment and medical management

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World Journal of Psychiatry 2022年第4期12卷 558-579页

作者： Stein Frostad Mette Bentz Department of Mental Health Research Division of PsychiatryHaukeland University HospitalBergen 5021Norway Child and Adolescent Mental Health Centre Capital Region of DenmarkUniversity of CopenhagenCopenhagen 2400Denmark

Anorexia nervosa(AN)is a disabling,costly and potentially deadly *** failure and relapse are common after completing treatment,and a substantial proportion of patients develop severe and enduring *** time from AN debut to the treatment initiation is normally unreasonably *** the past 20 years there has been empirical support for the efficacy of several treatments for ***,outpatient treatment with family-based therapy or individual psychotherapy is associated with good outcomes for a substantial proportion of *** intervention improves outcomes and should be a priority for all *** treatment is usually the best format for early intervention,and it has been demonstrated that even patients with severe or extreme AN can be treated as outpatients if they are medically *** care is more disruptive,more costly,and usually has a longer waiting list than does outpatient *** decision as to whether to proceed with outpatient treatment or to transfer the patient for inpatient therapy may be *** core aim of this opinion review is to provide the knowledge base needed for performing safe outpatient treatment of *** scientific essentials for outpatient treatment are described,including how to assess and manage the medical risks of AN and how to decide when transition to inpatient care is *** following aspects are discussed:early intervention,outpatient treatment of AN,including outpatient psychotherapy for severe and extreme AN,how to determine when outpatient treatment is safe,and when transfer to inpatient healthcare is *** treatments,ethical issues and outstanding research questions are also addressed.

关键词： Anorexia nervosa Outpatient treatment medical management Outpatient psychotherapy Inpatient healthcare

medical management of inoperable malignant bowel obstruction

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Medical management of inoperable malignant bowel obstruction

The Application of Block Chain Technology in medical management

2022第27届广东省药师周大会

作者： Xiaoyan Huang Jing Xue Min Gao Qiyuan Qin Tenghui Ma Xiaoyan Li Hui Wang Sun Yat-sen University Sixth Affiliated Hospital

Objective:Toreview medical management of inoperable malignant bowel *** Sources:A literature review using PubMed and MEDLINE databases searching malignant bowel obstruction,etiology,types,pathophysiology,medical,antisecretory,anti-inflammatory,antiemetic drugs,analgesics,promotion of emptying,prevention of infection,anticholinergics,somatostatin analogs,gastric antisecretory drugs,prokinetic agents,glucocorticoid,opioid analgesics,antibiotics,enema,adverse *** selection and data extraction:Randomized or observational studies,cohorts,case series,case reports or review written in English between 1983 toNovember 2020 were *** synthesis:Malignant bowel obstruction(MBO) commonly occurs in patients with advanced or recurrent malignancies and severely affects the quality of life and survival of *** management remains complex and *** surgery is the first choice for patients with MBO to regain patency of the bowel and resolve the obstruction,thus lessening the symptoms,it is not suitable for most *** management is the cornerstone of MBO treatment,with the goal of reducing distressing symptoms and optimizing quality of *** now,there has been neither a standard clinical approach nor registered medications to treat patients with inoperable *** to Patient Care and Clinical Practice:This review provides information on the etiology,type and pathophysiology,and medical treatment of MBO and related adverse reactionsof the drugs commonly used,what can greatly assist clinicians in making clinical decisions when treating ***:Published research shows medical management of MBO mainly from antisecretory,anti-inflammatory strategies,controlling vomiting and pain,promoting emptying,preventing infection and combination *** knowledgeable about the most current treatment options,the related adverse effects and the evidence supporting different practices is critical for clinicians toprov

关键词： Malignant bowel obstruction medical management Antisecretory Anti-inflammatory Control of vomiting Control of pain Promotion of emptying Prevention of infection

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Journal of Advances in Medicine Science 2021年第2期4卷 42-45页

作者： Wenjing Zhu Zhuanglian Mai First Affiliated Hospital of Jinan University GuangzhouGuangdong510630China

With the gradual development of social economy,the social function of medical institutions is becoming more and more *** the efficiency and quality of medical management can alleviate the contradiction between doctors and patients and improve the level of medical *** the sustainable development of medical institutions plays a key *** the background of the development of science and technology,the theoretical research and practical application of block chain technology are becoming more and more mature,which can not only store and transmit information effectively,but also strengthen the security of information *** effective combination of block chain technology and medical management can create a new operation mode and train of thought for medical management and promote the overall improvement of medical management quality and *** is very helpful to optimize the social service function in medical *** paper mainly expounds and probes into the concept characteristics of block chain technology,its concrete application in medical management,application effect control strategy and so *** aims to further strengthen the depth and breadth of application of block chain technology in medical management,provide strong power support for the improvement of medical management service level and promote the sustainable development of medical and health industry.

关键词： Blockchain technology medical management Information Application

Symptom presentation and evolution in the first 48 hours after injury are associated with return to play after concussion in elite Rugby Union

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Journal of Sport and Health Science 2024年第3期13卷 387-397页

作者： Ross Tucker Matt Cross Keith Stokes Lindsay Starling Rosy Hyman Simon Kemp Stephen West Martin Raftery Eanna Falvey James Brown Institute of Sport and Exercise Medicine(ISEM) Department of ExerciseUniversity of StellenboschTygerberg 7505South Africa World Rugby Ltd. Dublin D02 AE93Ireland Premiership Rugby London SW1V 1PXUK Centre for Health and Injury and Illness Prevention in SportUniversity of BathClaverton Down BA27AYUK UK Collaborating Centre on Injury and Illness Prevention in Sport(UKCCIIS) University of BathClaverton Down BA27AYUK Rugby Football Union London TW27BAUK London School of Tropical Medicine London WC1E 7HTUK Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgary T2N 1N4Canada Department of Medicine School of Medicine and HealthUniversity College CorkCork T12 EC8PIreland Carnegie Applied Rugby Research(CARR)centre Carnegie School of SportLeeds Beckett UniversityLeeds LS63QSUK

Background:Return to play(RTP)in elite rugby is managed using a 6-stage graduated RTP protocol,which can result in clearance to play within 1 week of *** aimed to explore how symptom,cognitive,and balance presentation and evolution during concussion screens 2 h(head injury assessment(HIA2)and 48 h(HIA3)after injury were associated with time to RTP)to identify whether a more conservative graduated RTP may be ***:A retrospective cohort study was conducted in 380 concussed rugby players from elite men’s rugby over 3 consecutive *** were classified as shorter or longer returns,depending on whether RTP occurred within 7 days(allowing them to be considered to play the match 1 week after injury)or longer than 8 days,***,cognitive,and balance performance during screens was assessed relative to baseline(normal or abnormal)and to the preceding screen(improving or worsening).Associations between sub-test abnormalities and RTP time were explored using odds ratios(OR,longer ***).Median day absence was compared between players with abnormal or worsening results and those whose results were normal or ***:Abnormal symptom results during screens 2 h and 48 h after concussion were associated with longer return time(HIA2:OR=2.21,95%confidence interval(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and 48 h post-injury was associated with longer return(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Median days absence was greater in players with abnormal symptom results at both HIA2 and *** and balance performance were not associated with longer return and did not affect median days ***:Symptom presentation and evolution within 48 h of concussion were associated with longer RTP *** may guide a more conservative approach to RTP,while still adhering to individualized concussion management principles.

关键词： Brain injury Concussion management General return to play medical management

Advancements in medical treatment for pancreatic neuroendocrine tumors:A beacon of hope

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World Journal of Gastroenterology 2024年第12期30卷 1670-1675页

作者： Somdatta Giri Jayaprakash Sahoo Department of Endocrinology and Metabolism Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry605006India

This editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors(pan-NETs),emphasizing tailored approaches for specific *** surgery and somatostatin analogs(SSAs)play pivotal roles in managing tumors,while palliative options such as molecular targeted therapy,peptide receptor radionuclide therapy,and chemotherapy are reserved for SSA-refractory ***,insul-inomas,glucagonomas,carcinoid tumors and VIPomas necessitate distinct thera-peutic *** the genetic basis of pan-NETs and exploring immunotherapies could lead to promising avenues for future *** review underscores the evolving landscape of pan-NET treatment,offering renewed hope and improved outcomes for patients facing this complex disease.

关键词： Pancreatic neuroendocrine tumor medical management Somatostatin analog Immunotherapy Everolimus

Current treatment of ulcerative colitis

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World Journal of Gastroenterology 2011年第27期17卷 3204-3212页

作者： Johannes Meier Andreas Sturm Department of Hepatology and Gastroenterology Charité-Universittsmedizin Berlin Campus Virchow Clinic13353 BerlinGermany

Ulcerative colitis (UC) is a chronic disease featuring re- current inflammation of the colonic mucosa. The goal of medical treatment is to rapidly induce a steroid-free remission while at the same time preventing complica- tions of the disease itself and its treatment. The choice of treatment depends on severity, localization and the course of the disease. For proctitis, topical therapy with 5-aminosalicylic acid (5-ASA) compounds is used. More extensive or severe disease should be treated with oral and local 5-ASA compounds and corticosteroids to induce remission. Patients who do not respond to this treatment require hospitalization. Intravenous steroids or, when refractory, calcineurin inhibitors (cyclosporine, tacrolimus), tumor necrosis factor-α antibodies (infliximab) or immunomodulators (azathioprine, 6-mercaptopurine) are then called for. Indications for emergency surgery include refractory toxic megacolon, perforation, and continuous severe colorectal bleeding. Close collaboration between gastroenterologist and surgeon is mandatory in order not to delay surgical therapy when needed. This article is intended to give a general, practice-orientated overview of the key issues in ulcerative colitis treatment. Recommendations are based on published consensus guidelines derived from national and international guidelines on the treatment of ulcerative colitis.

关键词： Ulcerative colitis Inflammatory bowel disease medical management Diagnosis Azathioprine TNF-α blocker

Perioperative use of immunosuppressive medications in patients with Crohn’s disease in the new"biological era"

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Gastroenterology Report 2017年第3期5卷 165-177,I0001页

作者： Amy L.Lightner Bo Shen Division of Colon and Rectal Surgery Mayo ClinicRochesterMinnesotaMNUSA Center for Inflammatory Bowel Diseases Digestive Disease and Surgery Institutethe Cleveland Clinic FoundationClevelandOHUSA

Crohn’s disease(CD)is characterized by transmural inflammation of the gastrointestinal tract leading to inflammatory,stricturing and/or and fistulizing *** a patient develops medically refractory disease,mechanical obstruction,fistulizing disease or perforation,surgery is ***,surgery is not curative in most cases,underscoring the importance of bowel preservation and adequate perioperative medical *** many of the medications used to treat CD are immunosuppressive,the concern for postoperative infectious complications and anastomotic healing are particularly concerning;these concerns have to be balanced with preventing and treating residual or recurrent *** herein review the available literature and make recommendations regarding the preoperative,perioperative and postoperative administration of immunosuppressive medications in the current era of biological therapy for *** algorithms for perioperative medical management would greatly assist future research for optimizing surgical outcomes and preventing disease recurrence in the future.

关键词： Crohn’s disease biological therapy perioperative period medical management

Retinoblastoma: concerning its initiation and treatment

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 397-401页

作者： Chang Luo Ying-Ping Deng Department of Ophthalmology West China Hospital Sichuan University

·Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on , the tumor suppressor gene that is responsible for the regulation of both cell cycle and gnome stability in retinal cells. Patients with a constitutional mutation on can be inherited. RB occurs approximately 1 in every 15 000-20 000 live births. The worldwide mortality for this cancer is about 5%-11%. However, this rate rises to about 40%-70% in developing countries due to a delay in diagnosis. A wide variety of options are available for the treatment, but often a combination of therapies is adopted to optimize individualized care. ·

关键词： retinoblastoma retinoblastomal gene leukocoria epidemiology medical management