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Retinoblastoma: concerning its initiation and treatment

Retinoblastoma: concerning its initiation and treatment

作     者:Chang Luo Ying-Ping Deng 

作者机构:Department of Ophthalmology West China Hospital Sichuan University 

出 版 物:《International Journal of Ophthalmology(English edition)》 (国际眼科杂志(英文版))

年 卷 期:2013年第6卷第3期

页      面:397-401页

核心收录:

学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主  题:retinoblastoma retinoblastomal gene leukocoria epidemiology medical management 

摘      要:·Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on , the tumor suppressor gene that is responsible for the regulation of both cell cycle and gnome stability in retinal cells. Patients with a constitutional mutation on can be inherited. RB occurs approximately 1 in every 15 000-20 000 live births. The worldwide mortality for this cancer is about 5%-11%. However, this rate rises to about 40%-70% in developing countries due to a delay in diagnosis. A wide variety of options are available for the treatment, but often a combination of therapies is adopted to optimize individualized care. ·

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