Retinoblastoma: concerning its initiation and treatment
Retinoblastoma: concerning its initiation and treatment作者机构:Department of Ophthalmology West China Hospital Sichuan University
出 版 物:《International Journal of Ophthalmology(English edition)》 (国际眼科杂志(英文版))
年 卷 期:2013年第6卷第3期
页 面:397-401页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题:retinoblastoma retinoblastomal gene leukocoria epidemiology medical management
摘 要:·Retinoblastoma (RB) is the most common intraocular cancer of infancy and childhood. This cancer is initiated by mutation on , the tumor suppressor gene that is responsible for the regulation of both cell cycle and gnome stability in retinal cells. Patients with a constitutional mutation on can be inherited. RB occurs approximately 1 in every 15 000-20 000 live births. The worldwide mortality for this cancer is about 5%-11%. However, this rate rises to about 40%-70% in developing countries due to a delay in diagnosis. A wide variety of options are available for the treatment, but often a combination of therapies is adopted to optimize individualized care. ·