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Characterization of Rebound Depolarization in Neurons of the Rat medial geniculate body In Vitro

Neuroscience Bulletin 2016年第1期32卷 16-26页

作者： Xin-Xing Wang Yan Jin Hui Sun Chunlei Ma Jinsheng Zhang Ming Wang Lin Chen CAS Key Laboratory of Brain Function and Diseases School of Life Sciences University of Science and Technology of China Auditory Research Laboratory School of Life SciencesUniversity of Science and Technology of China Department of Physiology Binzhou Medical University Department of Otolaryngology - Head and Neck Surgery Wayne State University School of Medicine

Rebound depolarization （RD） is a response to the offset from hyperpolarization of the neuronal mem- brane potential and is an important mechanism for the synaptic processing of inhibitory signals. In the present study, we characterized RD in neurons of the rat medial geniculate body （MGB）, a nucleus of the auditory thala- mus, using whole-cell patch-clamp and brain slices. RD was proportional in strength to the duration and magnitude of the hyperpolarization; was effectively blocked by Ni2＋ or Mibefradil; and was depressed when the resting membrane potential was hyperpolarized by blocking hyperpolarization-activated cyclic nucleotide-gated （HCN） channels with ZD7288 or by activating G-protein-gated inwardly-rectifying K＋（GIRK） channels with baclofen. Our results demonstrated that RD in MGB neurons, which is carried by T-type Ca2＋ channels, is critically regulated by HCN channels and likely by GIRK channels.

关键词： medial geniculate body Brain sliceRebound depolarizationchannel GIRK channel-type calcium channel - HCNResting membrane potential

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Neural population coding of sound with fidelity and flexibility through Stimulus-specific adaptation in medial geniculate body

Neural population coding of sound with fidelity and flexibil...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Xiong-Jie YU,Ju-Fang HE~* Laboratory of Applied Neuroscience and CAS-Hong Kong Joint-Laboratory for Visuo-auditory Integration,Department of Rehabilitation Sciences,The Hong Kong Polytechnic University,Hung Horn,Kowloon,Hong Kong

＜正＞Recent electrophysiological studies in animals,using an oddball stimulus paradigm,have demonstrated that the neurons in AC,TRN,MGB,and IC exhibited an enhanced response to a stimulus that was presented *** phenomenon is termed stimulus-specific adaptation（SSA）,which has been regarded as novelty ***,we analyze the relationships between the frequency response area（FRA） and SSA and the relationship between the sound pressure and SSA,using extracellular recording in the MGB of *** found that MGB neurons showed（1） strong SSA when the pure-tone stimulus in the oddball stimulus paradigm was far deviated from the best frequency（BF） and（2） strong SSA when the sound pressure of tones was *** combination of SSA,tuning curve and sound pressure level would enable MGB neurons to encode the auditory information with higher fidelity and sharpen contrast between different stimuli likely through population coding of different best frequency.

关键词： stimulus-specific adaptation novelty detection coding medial geniculate body

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Sodium salicylate,an aspirin metabolite,lowers the excitability of the medial geniculate body

Sodium salicylate,an aspirin metabolite,lowers the excitabil...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yan-Yan SU~1,Bin LUO~(1,*),Lin CHEN~(1,2,*) 1 Auditory Research Laboratory,School of Life Sciences,University of Science and Technology of China,Hefei 230027, China 2 CAS Key Laboratory of Brain Function and Disease,University of Science and Technology of China,Hefei 230027,China

＜正＞Previous studies suggest that sodium salicylate（NaSal）,an asparin metabolite,raises the neural excitability in the auditory cortex to cause *** the present study,we wanted to determine whether NaSal had a similar effect in the medial geniculate body（MGB）,a central auditory structure that provides the immediate inputs to the auditory *** whole-cell patch-clamp recordings from MGB slices in rats,we measured effects of NaSal（1.4 mmol/L） on neuronal intrinsic properties and the synaptic *** found that NaSa1 decreased the membrane input resistance,hyperpolarized the resting membrane potential,suppressed the current-evoked firing,changed action potential properties and depressed rebound *** also reduced the postsynaptic response evoked by stimulating the brachium of inferior colliculus（BIC）,indicating a reduction in efficacy of the synaptic transmission. Our results demonstrate that NaSal lowers the neural excitability via altering neuronal intrinsic properties and reducing the synaptic transmission in the MGB,which is distinct from its excitatory effects on the auditory *** suggest that NaSal-induced tinnitus may be partly due to the abnormal neural synchrony in the auditory cortex resulting from the reduced excitability of the MGB.

关键词： brain slice intrinsic property medial geniculate body salicylate synaptic transmission tinnitus whole-cell patch-clamp

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The spindle oscillations in the thalamic reticular nucleus,auditory thalamus,and cortex

The spindle oscillations in the thalamic reticular nucleus,a...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Chun-Hua LIU~(1,2),Yi-Ping GUO~1,Li-Xia GAO~(1,2),Xian-Kai MENG~3,Yan-Qin YU~(1,4),Ying-Shing CHAN~5,Ju-Fang HE~(1,2,*) 1 Department of Rehabilitation Sciences,The Hong Kong Polytechnic University,Hong Kong,China 2 Institute of Neuroscience,Shanghai Institute of Biological Sciences,Chinese Academy of Sciences,Shanghai,China 3 Institute of Biophysics,Chinese Academy of Sciences,Beijing,China 4 Department of Physiology,Zhejiang University,Hangzhou,China 5 Department of Physiology and Research Centre of Heart,The University of Hong Kong,Hong Kong,China

In the present study,we investigated the spindle oscillation in the thalamic reticular nucleus(TRN),medial geniculate body(MGB) and auditory cortex(AC).Neuronal activities in above regions were simultaneously recorded with extracellular and intracellular *** have found that thalamocortical neurons exhibit membrane oscillations that have spindle frequencies consist of excitatory postsynaptic potentials(EPSP).Acoustic stimuli could trigger membrane oscillation in EPSPs with *** lesioning or injection of a combination of GABA and GABA antagonists into the MGB resulted in slowed oscillation in the *** of GABA antagonist into the MGB decreased oscillation frequency in the MGB and *** oscillation frequency of the MGB neurons was fastened by rhythmic electrical stimulation of the TRN on *** results proposed that the spindle is initiated in the dorsal thalamus,modulated by the TRN,and propagated to the forebrain.

关键词： spindle oscillation thalamic reticular nucleus medial geniculate body auditory cortex excitatory postsynaptic potential(EPSP) GABA receptor antagonist

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Auditory thalamus neurons contribute to the coding of surprise

Auditory thalamus neurons contribute to the coding of surpri...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Flora M.ANTUNES Manuel S.MALMIERCA Auditory Neurophysiology Unit Laboratory for the Neurobiology of HearingInstitute of Neuroscience of Castilla y LeonUniversity of SalamancaSpain

＜正＞Objective Neurons in the cat auditory cortex（AC;Ulanovsky et al.,2003） and in the rat inferior culliculus（IC;Perez-Gonzalez et al.,2005,Malmierca et al.,2009）,show a reduced response to a repeated stimulus（deviant）,and briefly resume firing if a novel stimulus（oddball） is presented,i.e.,they show stimulus-specific adaptation（SSA）.To date,no study demonstrated high levels of SSA in the medial geniculate body（MGB） as those found in the AC and *** that the MGB receives its inputs from both the AC and IC it is unclear why MGB does not exhibit similar levels of SSA. Thus,our main goal is to examine if neurons in the MGB show a similar type of SSA as neurons in the AC and in the IC. Methods We recorded single unit extracellular responses,in the MGB of urethane anaesthetized rats,using a similar stimulation paradigm as the one used in the AC and IC *** included the three main subdivisions of the *** Our data demonstrate that a high percentage of neurons in the MGB adapt to the standard stimulus but not to the oddball *** of the neurons in the dorsal and medial subdivisions exhibited extreme levels of SSA,firing almost entirely to the oddball tone,and behaving as surprise *** neurons maintained a high degree of SSA even at very extreme conditions,e.g.,at the combination of a frequency contrast as small as 0.14 octaves and an ISI as long as 2000 *** SSA neurons were mainly onset responders with short latency,but some neurons with tonic and also long latency responses showed high levels of *** We provide evidence for a very rapid and sensitive to the stimuli statistics type of adaptation,that may be mediated by diverse neuronal *** results taken together with those from the AC and the IC,demonstrate the ubiquity of this type of adaptation in neurons from the midbrain level up to the *** hypothesize that SSA may be shaped in a bottom-up process.

关键词： medial geniculate body stimulus-specific adaptation oddball paradigm surprise detectors

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Slow recovery from excitation of thalamic reticular nucleus neurons

Slow recovery from excitation of thalamic reticular nucleus ...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Xiong-Jie YU~1,Shi-Gang HE~1,Ju-Fang HE~(1,2) 1 Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2 Depatment of Rehabilitation Sciences,The Hong Kong Polytechnic University,Hong Kong

＜正＞Objective To investigate the temporal response property of the thalamic reticular nucleus（TRN）.Methods Extracelluary recording was made in the TRN auditory sector and medial geniculate body（MGB） while the noise burst was presented to the rat with interstimuli interval（ISI） from 200 ms to *** The neuronal responses to the repeated auditory stimuli and electrical stimulation were examined on 95 neurons in the auditory sector of the thalamic reticular nucleus and 21 medial geniculate neurons from anesthetized *** TRN neurons showed strong response to the first trial and weak response to *** trials of the repeated auditory stimuli,when the inter-stimulus interval was short （＜3 s）.They responded in the second trial with a firing and sustaining of oscillation similar to that in the first trial,when the ISI was increased to 7 s or even *** was of a great contrast to the MGB neurons,which responded similarly to the repeated auditory stimuli of different *** TRN neurons showed a statistically significant increase in the onset auditory response from 20 Hz to 72 Hz when the ISI was increased from 200 ms to 10 s（P ＜ 0.001,ANOVA）.The TRN neurons responded to repeated electrical stimulation of MGB and auditory cortex similarly to the repeated auditory *** stimuli evoked oscillatory firing activities in the TRN *** sustaining of the oscillation was longer when the ISI was *** sustaining of the oscillation was correlated with the latency of the second cluster of spikes,implying that the oscillation consisted of LTS *** The slow recovery of the TRN neurons after oscillation of burst firings to fast repetitive stimulus was a reflection of a different role than the thalamocortical relay *** that the TRN is involved in the process of attention such as attention shift,the slow recovery of TRN neurons probably limits the frequent change of the attention in a fast rhythm.

关键词： thalamic reticular nucleus oscillation medial geniculate body auditory response electrical stimulation auditory cortex

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The interaction between the thalamic reticular nucleus and dorsal thalamus

The interaction between the thalamic reticular nucleus and d...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Xiong-Jie YU~(1,2),Xin-Xiu XU~1,Shi-Gang HE~1,Ju-Fang HE~(1,2,*) 1 Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2 Department of Rehabilitation Sciences,The Hong Kong Polytechnic University,Hung Horn,Kowloon,Hong Kong

＜正＞The TRN neurons showed significantly stronger responses to the pure-tone stimulus of the same frequency when it was presented as the deviant stimulus with low appearance probability than as the standard stimulus with high *** some MGB neurons also showed the deviance-preference,the deviance-detection index of TRN neurons was significantly greater than that of MGB neurons（0.321 vs 0.154）.The functional implication of the deviance detection of TRN neurons was examined through their output target,MGB neurons,with a deviance paradigm before a probe *** this paradigm,14 MGB neurons were modulated with enhancement and 27 with suppression. Inactivation of the auditory TRN neutralized the deviance modulation effect on the *** modulation effects were *** detection likely enables TRN neurons to transiently deactivate surrounding TRN neurons in response to a fresh stimulus,causing both enhancive and suppressive effects on the auditory thalamus and resulting in attention shift.

关键词： thalamic reticular nucleus oscillation medial geniculate body auditory response habituation

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