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Studies on the Specific degranulation of mast cell Sensitized by Several Allergens in vitro

cellular & Molecular Immunology 2009年第2期6卷 149-153页

作者： Yongchao Guo Zhenxing Li Hong Lin Haider Samee Jamil Khalid Food safety laboratory Ocean University of China Qingdao 266003. Shandong China Pakistan Council for Scientific and Industrial Research Laboratories Complex Karachi Pakistan

Food allergy is a major health issue worldwide. mast cells play a very important role in the immediate hypersensitivity for which mast cell degranulation needs to be studied extensively. In this study, an approach was taken to study the characteristics of sensitized mast cell degranulation in vitro, which associated with the study of mast cells and animal models. BALB/c mice were immunized respectively by several food allergens, then blood and peritoneal mast cells were collected at different time points. A dynamic determination was carried out between mast cells and serumal IgE. Comparative analysis on sequential time points showed that there was a close coincidence between mast cell degranulation and IgE antibody titers in sensitized BALB/c mice. Furthermore, it is interesting that sensitized mast cells could implement specific degranulation against the challenges in vitro, but the closely tropomyosins induced mast cell degranulation displayed cross reactions. This is very similar to IgE resisting the allergens in vivo. The study disclosed some characteristics on mast cells, coming from sensitized BALB/c mice, degranulation in vitro.

关键词： food allergy allergen mast cell degranulation

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Panax Notoginseng Saponins Restrains Ischemia-reperfusion-induced Rat Mesenteric Microcirculatory Disturbance

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World Journal of Traditional Chinese Medicine 2015年第3期1卷 1-8页

作者： Yu Zhang Yu-Ying Liu Quan Li Chun-Shui Pan Jing-Yu Fan Chuan-She Wang Kai Sun Jing-Yan Han Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking University Key Laboratory of Microcirculation State Administration of Traditional Chinese Medicine of the People’s Republic of China Key Laboratory of Stasis and Phlegm State Administration of Traditional Chinese Medicine of the People’s Republic of China Tasly Microcirculation Research Center Peking University Health Science Center

Objective: To investigate the effect of Panax notoginseng saponins(PNS) on ischemia reperfusion(I/R) induced rat mesenteric microcirculatory ***: Male Wistar rats weighting 200–250 g were subjected to 10 min ligation of the superior mesenteric artery and vein, followed by60 min reperfusion. PNS(5 mg/kg/hr) was continuously administrated starting from 10 min before ischemia or 10 min after reperfusion until60 min after reperfusion via left jugular vein. Leukocytes adhesion, mast cell degranulation, endothelial peroxidation, and albumin leakage of rat mesenteric venules were observed. Serum myeloperoxidase(MPO) level, intercellular adhesion molecule-1(ICAM-1) expression and Src phosphorylation were ***: PNS ameliorated leukocyte adhesion and mast cell degranulation, while with no obvious effects on endothelial peroxidation and albumin leakage. In addition, PNS inhibited serum MPO increase, intestinal ICAM-1 expression and Src phosphorylation induced by I/***: PNS ameliorated I/R-induced leukocyte adhesion and mast cell degranulation, the former is related to its inhibition of Src phosphorylation and ICAM-1 expression.

关键词： ICAM-1 Src leukocytes adhesion mast cell degranulation panax notoginseng

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维普期刊数据库

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Pterostilbene inhibits FcεRI signaling in mast cells during anaphylaxis

Pterostilbene inhibits FcεRI signaling in mast cells during...

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第十四届全国免疫学学术大会

作者： Chongyang Wang Liangchang Li Chang Xu guanghai Yan Yanbian University

In this study,the role and mechanism of pterostilbene(Pts) in mast cell degranulation in vitro and in vivo were *** results showed that Pts inhibited mast cell-mediated local passive allergic reactions in *** addition,treatment with Pts reduced both histamine release and calcium influx in rat peritoneal mast cells and RBL-2 H3 cells and reduced Ig E-mediated mast cell ***,the mechanism underlying Pts inhibition of mast cell signaling was probed via studying the effects of Pts on liver kinase B1(LKB1),including the use of the LKB1 activator metformin and siRNA knockdown of *** data showed that Pts reduced the release of inflammatory mediators such as tumor necrosis factor-a,interleukin-6,leukotriene C4,and prostaglandin D2 in mast cells by activating the LKB1/adenosine monophosphate(AMP)-activated protein kinase(AMPK) signaling ***,Pts inhibited phosphorylation of FcεRI and FcεRI-mediated degranulation in RBL-2 H3 *** effects were attenuated after LKB1 *** together,Pts could inhibit FcεRI signaling through activation of the LKB1/AMPK signaling pathway in Ig E-mediated mast cell ***,Pts might be an effective therapeutic agent for mast cell mediated allergic diseases.

关键词： pterostilbene mast cell degranulation LKB1 AMPK FcεRI signaling

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