Panax Notoginseng Saponins Restrains Ischemia-reperfusion-induced Rat Mesenteric Microcirculatory Disturbance

作     者：Yu Zhang Yu-Ying Liu Quan Li Chun-Shui Pan Jing-Yu Fan Chuan-She Wang Kai Sun Jing-Yan Han 

作者机构：Department of Integration of Chinese and Western MedicineSchool of Basic Medical SciencesPeking University Key Laboratory of MicrocirculationState Administration of Traditional Chinese Medicine of the People’s Republic of China Key Laboratory of Stasis and PhlegmState Administration of Traditional Chinese Medicine of the People’s Republic of China Tasly Microcirculation Research CenterPeking University Health Science Center 

出 版 物：《World Journal of Traditional Chinese Medicine》 (世界中医药杂志（英文）)

年 卷 期：2015年第1卷第3期

页      面：1-8页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Production of New Medicine Program of Ministry of the Science and Technology of the People’s Republic of China[2010ZX09401-406] 

主　　题：ICAM-1 Src leukocytes adhesion mast cell degranulation panax notoginseng 

摘      要：Objective: To investigate the effect of Panax notoginseng saponins(PNS) on ischemia reperfusion(I/R) induced rat mesenteric microcirculatory ***: Male Wistar rats weighting 200–250 g were subjected to 10 min ligation of the superior mesenteric artery and vein, followed by60 min reperfusion. PNS(5 mg/kg/hr) was continuously administrated starting from 10 min before ischemia or 10 min after reperfusion until60 min after reperfusion via left jugular vein. Leukocytes adhesion, mast cell degranulation, endothelial peroxidation, and albumin leakage of rat mesenteric venules were observed. Serum myeloperoxidase(MPO) level, intercellular adhesion molecule-1(ICAM-1) expression and Src phosphorylation were ***: PNS ameliorated leukocyte adhesion and mast cell degranulation, while with no obvious effects on endothelial peroxidation and albumin leakage. In addition, PNS inhibited serum MPO increase, intestinal ICAM-1 expression and Src phosphorylation induced by I/***: PNS ameliorated I/R-induced leukocyte adhesion and mast cell degranulation, the former is related to its inhibition of Src phosphorylation and ICAM-1 expression.