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Analisys of Immunohistochemical Prognostic Markers in Canine mammary cancer and Its Relation to Postsurgical Survival

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Open Journal of Pathology 2015年第3期5卷 90-99页

作者： Francisco Pedraza-Ordonez Luis Mauricio Montoya-Florez Camilo Bulla Noeme Sousa Rocha Department of Veterinary Clinics Laboratory of Investigative and Comparative PathologySchool of Veterinary Medicine and Animal ScienceUniversidade Estadual Paulista FMVZ-UNESPSao PauloBrazil Animal Pathology Research Group Animal Health DepartmentUniversidad de CaldasManizalesColombia Department of Pathology/Population Medicine-Mississippi College of Veterinary Medicine Mississippi State UniversityStarkvilleUSA Department of Pathology Botucatu Medical SchoolUniversidade Estadual Paulista–UNESPDistrito de Rubiao Junior s/nBotucatuBrazil

Background: Several animal models, including dogs, have been useful to compare the pathogenesis of mammary neoplasm in humans, showing biological parallelism in the growth and development of breast cancer. The causes of cancer could be attributed to change in several tumor suppressor genes. The relationship between molecule associated to senescence and clinical prognosis of patients affected by mammary cancer is little known. Beyond a collection of data, the major interest of the present study was to carry out a clinical follow-up of patients affected by these tumors, through association with new molecular markers by immunohistochemical technic. Upon completing the study, 15 patients survived, while 45 died. In the case of malignant neoplasms, 40 patients died because of the illness. The type of surgery most used by veterinarian surgeons was the simple lumpectomy, followed by the regional mastectomy. Sentinel node was removed by surgery only when clearly affected. Result: Markings against steroid hormones were positive. Regarding the markings against HER2 and Ki-67, they were negative in all cases. The markings against P53 and CD31 were all positives. Markings against molecules associated with cellular senescence were all positives. No statistical differences were found in immunomarcation for the different antigens used as clinical prognosis factors in mammary neoplasms. Conclusions: According to the study conditions, the survival of patients affected by breast tumors is directly related to diagnosis and malignancy histological grade, but not to animal breed, number of affected glands or patient reproductive status. On the other hand, immunohistochemical markings were not related to the patient prognosis. For this reason, it is important to highlight the persistance of a high percentage of mammary neoplasm cases clinically diagnosed with poor results on patient survival. Thus, educating owners and veterinarians for using diagnostic available tools to improve the pro

关键词： Celular Senescence Prognostic Markers Immunohistochemical mammary cancer Animal Model

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Clinical Study on Treatment of mammary cancer by Shenqi Fuzheng Injection (参芪扶正注射液) in Cooperation with Chemotherapy

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Chinese Journal of Integrative Medicine 2007年第1期13卷 37-40页

作者：杨波李洪胜祁岩超卢敏莹 Department of Biomedical Engineering Affiliated Hospital of Guangzhou Medical College

Objective： To study the effect of Shenqi Fuzheng Injection （参芪扶正注射液,SFI） on cellular immune in patients with mammary cancer （MC） after chemotherapy. Methods： One hundred and ten patients with MC were randomly assigned to two groups. The 58 patients in the tested group were treated with SFI in cooperation with chemotherapy of CAF protocol （Cyclophosphamide, Doxorubicin and Fluorouracil）, while the 52 patients in the control group were treated with chemotherapy of the same protocol alone. Changes of the patients＇ quality of life （QOF）, adverse reaction that occurred, peripheral lymphocyte count and killing activity of single karyocyte before and after treatment between the two groups were compared. Results： Patients＇ QOF elevating rate after treatment in the tested group and the control group was 34.5% and 13.5% respectively; The lowering of peripheral blood cell count of WBC, platelet and lymphocyte as well as that of the killing activity of single peripheral karyocyte on various kinds of MC cells were all milder and recovery sooner than those in the control group. Conclusion： SFI in combination with chemotherapy in treating MC could reduce the occurrence of adverse reaction to chemotherapy, improve clinical symptoms, elevate QOF and enhance immunity in patients with MC.

关键词： Shenqi Fuzheng Injection chemotherapy mammary cancer cellular immune

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EffectofAcupunctureonlmmunologicFunctionandHistopathologyofTransplantedmammarycancerinMice

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Chinese Journal of Integrative Medicine 1996年第3期2卷 225-227页

作者：刘丽军郭诚杰焦新民殷克敬

This experiment mainly describes the effects of acupuncture on immunologic function andhistopathology of transplanted mammary cancer in mice. The results were as follows: In acupuncture group,NK cell activity and T-lymphocyte positive rate of acid a-naphthyl acetate esterase (ANAE) and lymphocytetransformation rate were all increased. Compared with the control group, there was a significant difference( P 0 . 05) . Comparing thepathology grading of acupuncture group with control group, it showed marked difference in pathological sec-tion ( Pmammary cancer in mice and inhibit the growth of mammary cancer and enhance both differentia-tion level of mammary cancer cells and lymphocytic infiltration. Possibly acupuncture might reduce the malig-nancy of mammary cancer cells.

关键词： acupuncture mammary cancer immunologic function histopathology

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NON-LINEAR OPTICAL IMAGING OF OBESITY-RELATED HEALTH RISKS:REVIEW

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Journal of Innovative Optical Health Sciences 2009年第1期2卷 9-25页

作者： THUC T.LE JI-XIN CHENG Weldon School of Biomedical Engineering Purdue University West Lafayette Indiana 47907USA Department of Chemistry and Weldon School of Biomedical Engineering Purdue University West Lafayette Indiana 47907USA

This review highlights the recent applications of non-linear optical(NLO)microscopy to study obesity-related health risks.A strong emphasis is given to the applications of coherent anti-Stokes Raman scattering(CARS)microscopy where multiple non-linear optical imaging modalities including CARS,sum-frequency generation(SFG),and two-photon fluorescence are employed simultaneously on a single microscope *** examples on applications of NLO microscopy to study lipid-droplet biology,obesity-cancer relationship,atherosclerosis,and lipidrich biological structures are discussed.

关键词： Atherosclerosis coherent anti-Stokes Raman scattering lipid droplet mammary cancer non-linear optics obesity second harmonic generation sum-frequency generation twophoton fluorescence tumor stroma

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Analysis of the Risk Factors of Upper Limb Lymphedema after Breast cancer Surgery and Nursing Care

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Journal of Clinical and Nursing Research 2021年第5期5卷 12-17页

作者： Linlin Qian Yancheng's First People's Hospital Yancheng 224000Jiangsu ProvinceChina

Objective:To evaluate and analyze the influencing factors of upper limb lymphedema after breast cancer surgery,and to study effective nursing intervention ***:500 cases of early breast cancer patients from October 2017 to December 2020 were selected,all patients underwent surgical intervention,retrospectively analyzed the basic clinical data of patients,and statistically analyzed the influencing factors of upper limb *** patients with upper extremity lymphedema received high-quality nursing intervention,and the specific nursing effect was ***:Logistic regression analysis showed that the risk factors of upper limb lymphedema after breast cancer surgery included hypertension,postoperative upper limb functional exercise,delayed healing of incision,radiotherapy and so *** nursing intervention,the patients*12*5 elbow 10cm,elbow 10cm,wrist size value and VAS score were better than those before nursing(Pcancer *** nursing intervention can alleviate the condition of patients with upper limb lymphedema and improve their quality of life,which is worthy of comprehensive promotion.

关键词： mammary cancer Lymphedema of upper extremity Occurrence factors Nursing

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Clinical Observation on Zhengan Xifeng Decoction(镇肝熄风汤)in Treating Peri-Menopausal Syndrome

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Chinese Journal of Integrated Traditional and Western Medicine 2003年第1期9卷 63-66页

作者：李琼舒仪琼赖慧红陈朝辉 The First Affiliated Hospital University of Sun YatsenGuangzhou 510080 Affiliated Hospital to Anhui TCM College

Menopausal syndrome is the transforming stage of women’s sexual function frommature to *** to the decline ofovarium function, estrogen secretion gradually reduced and a syndrome *** medicine it is suggested to use hor

关键词： pulmonary embolism clinical trials mammary cancer United States heart disease

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